Evaluation of feed restriction effects on mineral metabolism of intact male, female and castrated male goat kids

2019 ◽  
Vol 59 (12) ◽  
pp. 2252
Author(s):  
Paula Fernanda Varella Santos ◽  
Carla Joice Härter ◽  
Nhayandra Christina Dias e Silva ◽  
Rafael Fernandes Leite ◽  
Fernanda Oliveira de Miranda Figueiredo ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Phosphatase Activity ◽  
Alkaline Phosphatase Activity ◽  
Mineral Metabolism ◽  
The Body ◽  
Feed Restriction ◽  
Mineral Density ◽  
Saanen Goat ◽  
Magnesium Metabolism ◽  
Ad Libitum

The objective of the present study was to evaluate the effects of feed restriction on calcium (Ca), phosphorus (P) and magnesium metabolism in goat kids from 15 to 30 kg bodyweight, and to evaluate the role of sex in these processes. The study used a split plot design comprising three sex groups (intact males, castrated males and females), and the subplot comprised three levels of feed restriction (0% (ad libitum), 25% and 50%). Mineral intake and retention, mineral concentration in the blood, alkaline phosphatase activity and bone mineral density (BMD) of the femur were determined. The data were analysed as mixed models. Daily Ca, P and magnesium retention in the body decreased linearly with increasing feed restriction (P < 0.05). At 50% feed restriction, we observed a 22% reduction of alkaline phosphatase activity, and 9% and 7% reductions of Ca and P contents in blood serum. The BMD of females fed ad libitum was greater than castrated and intact males, whereas when subjected to 50% feed restriction, no differences in BMD were noted among the sexes (P < 0.01). Irrespective of feed restriction, females tended to retain less P in their bodies (P < 0.10) and tended to have the lowest P serum concentrations (P = 0.08). Our results indicated that only females showed decreased BMD under feed restriction; Ca, P and magnesium metabolism in prepubertal Saanen goat kids was mainly affected by feed restriction, whereas sex mainly affected the P metabolism.

177 Ad Libitum Consumption of a 1:1 Blend of inorganic:organic Se by Steers Grazing Endophyte-infected Tall Fescue Increases Serum Prolactin and Alkaline Phosphatase Activity, but Not Average Daily Gain

2021 ◽  
Vol 99 (Supplement_3) ◽  
pp. 94-95
Author(s):  
Kelsie Webb ◽  
Ronald J Trotta ◽  
Phillip Bridges ◽  
James Matthews
Keyword(s):  
Alkaline Phosphatase ◽  
Phosphatase Activity ◽  
Alkaline Phosphatase Activity ◽  
Tall Fescue ◽  
Average Daily Gain ◽  
Serum Prolactin ◽  
Negative Effects ◽  
Ad Libitum ◽  
Ad Libitum Intake ◽  
Daily Gain

Abstract To test the hypothesis that average daily gain (ADG) and clinical parameters of steers grazing novel non-toxic (NTE) or toxic KY-31 (TE) endophyte-infected tall fescue would be improved by ad libitum intake of vitamin-mineral mixes (V-M) that contain 27 ppm Se as a 1:1 blend of SELPLEX:sodium selenite (MIX) vs sodium selenite (ISe), 32 TE-naïve beef steers depleted of Se were randomly assigned to ad libitum consumption ISe vs MIX for 35 d and fed enough of a NTE/alfalfa/grain diet to achieve 0.57 kg BW gain/d. Within Se-form treatments, 2 steers were randomly assigned to each of 4, 2-acre NTE (ISe = 316 ± 31 kg, MIX = 315 ± 22 kg) or TE (ISe = 316 ± 37 kg, MIX = 314 ± 39 kg) paddocks for 84 d and had ad libitum access to their respective V-M. The MIXED procedure of SAS was used to assess effects of day, Se-form (ISe, MIX) and endophyte (NTE, TE) treatments, and their interactions. Whole blood Se decreased (P < 0.01) 31% from d 0 to 84 and was 6.2% greater (P < 0.01) for MIX steers. Serum prolactin decreased (P < 0.01) 18% for NTE and 48% for TE steers from d 0 to 84 and was 17% greater (P = 0.01) for MIX vs. ISe TE steers. Alkaline phosphatase activity (AP) decreased (P < 0.02) 27% from d 0 to 84 and was 15% greater (P < 0.02) for MIX steers. Serum urea nitrogen increased (P < 0.02) 8.2% from d 0 to 84 for TE but not NTE steers. Average daily gain (kg/d) was less (P < 0.01) in TE (-0.18) vs NTE (0.09) steers. We conclude that the ad libitum intake of MIX ameliorated the negative effects of consuming TE on serum prolactin and AP but not ADG.

scholarly journals Mineral metabolism of pregnant goats under feed restriction

2017 ◽  
Vol 57 (2) ◽  
pp. 290 ◽  
Author(s):  
Carla J. Härter ◽  
Lisiane D. Lima ◽  
Douglas S. Castagnino ◽  
Astrid R. Rivera ◽  
Alana M. Nunes ◽  
...  
Keyword(s):  
Fixed Effects ◽  
Mineral Metabolism ◽  
Block Design ◽  
Random Effect ◽  
Serum Levels ◽  
The Body ◽  
Feed Restriction ◽  
Mineral Density ◽  
Maternal Body ◽  
Sodium And Potassium

We examined the effects of feed restriction on calcium, phosphorus, magnesium, sodium and potassium metabolism in Oberhasli and Saanen goats during gestation. The 63 goats were distributed into groups that were divided into three levels of feed restriction (0%, 20% and 40% restriction) and slaughtered at different pregnancy stages (80, 110 and 140 days of gestation), in a randomised block design with a 2 × 3 × 3 factorial arrangement. The mineral balance was determined at ~80, 110 and 140 days of gestation. The serum levels of minerals and alkaline phosphatase activity were determined during pregnancy. Mineral retention in the maternal body, femur, empty uterus, mammary gland, fetus and fetal fluid was also determined during gestation. Bone mineral density was measured in the femur. Mixed models with days of gestation, levels of feed restriction, breed and their interactions as fixed effects and blocks as random effect were used for data analysis. In response to the reduction in feed intake, the maternal body uses its mineral reserves to maintain gestation. Physiological adjustments of the goats subjected to 20% feed restriction avoided a decrease in fetal mineral deposition. More severe feed restriction, however, compromised concentrations of phosphorus, sodium and potassium in the fetus, which were the main minerals used by the maternal body, whereas calcium and magnesium deposition in fetuses remained unaffected. At 40% feed restriction, the retention of all minerals in the body decreased, and the fetal dry mass was on average also less than those fetuses from goats without feed restriction. The fetal deposition of phosphorus, sodium and potassium was also lower during 40% restriction.

scholarly journals Reproductive Toxicity to Male Mice of Nose Only Exposure to Water- Pipe Smoke

2015 ◽  
Vol 35 (1) ◽  
pp. 29-37 ◽  
Author(s):  
Badreldin H. Ali ◽  
Sirin A. Adham ◽  
Khalid A. Al Balushi ◽  
Asem Shalaby ◽  
Mostafa I. Waly ◽  
...  
Keyword(s):  
Alkaline Phosphatase ◽  
Phosphatase Activity ◽  
Alkaline Phosphatase Activity ◽  
Total Protein ◽  
Plasma Concentrations ◽  
Reproductive Toxicity ◽  
Growth Factor Receptor ◽  
The Body ◽  
Water Pipe ◽  
Endothelial Growth Factor

Background/Aims: Water-pipe smoking (WPS) is popular in the Middle East and is starting to gain popularity in several Western countries as well. It is widely and erroneously perceived to be less harmful than other forms of tobacco use. The reproductive adverse effects of cigarette smoking have been studied before with conflicting results, but data on the possible adverse reproductive effects of WPS are lacking. Here, we assessed the effects of nose-only exposure to mainstream WPS generated by commercially available honey-flavored "moasel" tobacco in mice. Methods: The duration of the session was 30 min/day for one month. Control mice were exposed to air. Twenty- four h after the last exposure, mice were killed and the testes and plasma removed for analysis. In testicular homogenates total protein, alkaline phosphatase activity, several indices of oxidative damage and Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) were quantified. The plasma concentrations of leptin, testosterone, estrogen and luteinizing hormone (LH) were also measured. Histological analysis of testes and lungs was also conducted. Results: WPS caused statistically significant decreases in the plasma concentrations of leptin, testosterone, and LH, and in the concentrations of total protein and the antioxidant indices measured. A statistically non - significant decrease in VEGFR2 protein in the WPS - exposed mice compared to the control mice was also found. The body and testicular weights of mice exposed to WPS, as well as their testicular alkaline phosphatase activity and light microscopic histology, and plasma estrogen concentration were all not significantly affected by WPS. Conclusion: Further studies on the functional implications of these findings in mice exposed to WPS for longer durations are warranted.

Carbohydrate reserves and phosphatase activity in the mollusc-trematode relationship ofMytilus edulisL. andProctoeces maculatus(Looss, 1901) Odhner, 1911

1974 ◽  
Vol 48 (1) ◽  
pp. 1-14 ◽  
Author(s):  
Emmet A. Dennis ◽  
Marian Sharp ◽  
Rudd Douglass
Keyword(s):  
Alkaline Phosphatase ◽  
Phosphatase Activity ◽  
Alkaline Phosphatase Activity ◽  
Leydig Cells ◽  
Glycogen Content ◽  
Maximum Level ◽  
The Body ◽  
Rapid Decline ◽  
Carbohydrate Reserves ◽  
High Metabolic Activity

AbstractBiochemical and histochemical techniques were employed to study tissue distribution, and concentrations of carbohydrate reserves and phosphatase activity in uninfected Mytilus edulis and specimens parasitized byProctoeces maculatus. Glycogen was stored in the mantle, hepatopancreas, labial palps and mesosomal Leydig cells of the mussel, and in the body parenchyma of post-miracidial stages of the trematode. The glycogen content of the mantle and hepatopancreas increased steadily from January to a maximum level in June and then declined sharply to a minimum level in December. No differences were observed in the annual glycogen cycle of infected and uninfected mussels. Starvation of mussels at a temperature conducive to high metabolic activity of the worms resulted in a rapid decline in the glycogen content of infected mussels by the first week of starvation. A stable glycogen concentration was maintained for 4 weeks by starved uninfected mussels. The distribution of acid phosphatase activity in the tissues ofM. edulisandP. maculatuswas greater than that of alkaline phosphatase activity, but increased alkaline phosphatase activity was observed in the haemolymph of mussels infected with adultP. maculatus.

scholarly journals Anti-Osteoporotic Effects of Antioxidant Peptides PIISVYWK and FSVVPSPK from Mytilus edulis on Ovariectomized Mice

Antioxidants ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 866 ◽  
Author(s):  
Yunok Oh ◽  
Chang-Bum Ahn ◽  
Won Ho Cho ◽  
Na Young Yoon ◽  
Jae-Young Je
Keyword(s):  
Alkaline Phosphatase ◽  
Phosphatase Activity ◽  
Signaling Pathway ◽  
Alkaline Phosphatase Activity ◽  
Bmp Signaling ◽  
Type I ◽  
Antioxidant Peptides ◽  
Mineral Density ◽  
Food Ingredients ◽  
Ovariectomized Mice

Numerous amounts of evidence suggest that bioactive peptides with diverse physiological activities can be nutraceuticals or potential drug candidates. In this study, blue mussel-derived antioxidant peptides PIISVYWK and FSVVPSPK were subjected to evaluate their osteogenic effect in mouse bone marrow mesenchymal stem cells (mBMMSCs) followed by an in vivo anti-osteoporotic effect. Treatment of PIISVYWK and FSVVPSPK on mBMMSCs stimulated alkaline phosphatase activity and calcification. Western blot results revealed that PIISVYWK and FSVVPSPK increased the expression of bone morphogenetic protein-2/4 (BMP-2/4) followed by upregulating p-Smad1/5, type I collagen, and transcription factors including Runx2 and osterix in mBMMSCs. Two peptides also activated the phosphorylation of MAPKs (p-p38, p-ERK, and p-JNK). Treatment of MAPK inhibitors significantly inhibited the BMP signaling pathway, indicating that PIISVYWK and FSVVPSPK stimulated osteoblast differentiation of mBMMSCs through the MAPK-dependent BMP signaling pathway. The anti-osteoporotic effect of PIISVYWK and FSVVPSPK in ovariectomized (OVX) mice was investigated. Treatment of PIISVYWK and FSVVPSPK for ten weeks showed a notable anti-osteoporotic effect in OVX mice via increasing bone mineral density and other bone parameters compared to OVX mice without peptides. Serum analysis also showed that treatment of PIISVYWK and FSVVPSPK completely reduced osteocalcin and ALP (alkAline phosphatase) activity. Taken together, these results suggest that PIISVYWK and FSVVPSPK could be health-promoting functional food ingredients against osteoporosis.

Peculiarities of the shanges of characteristics of osteal regeneration in associated trauma

1993 ◽  
Vol 74 (2) ◽  
pp. 114-116
Author(s):  
N. M. Gruber
Keyword(s):  
Alkaline Phosphatase ◽  
Phosphatase Activity ◽  
Alkaline Phosphatase Activity ◽  
Hormonal Regulation ◽  
Mineral Metabolism ◽  
Fibrous Tissue ◽  
Craniocerebral Trauma ◽  
Organic Matrix ◽  
Inorganic Phosphorus

The levels of inorganic phosphorus, calcium, free, connected and common oxyproline, alkaline phosphatase activity in blood are investigated in the experiment of standard craniocerebral trauma in connection wth the fracture of crus bones. The data obtained suggest the breaking of the coordination of hormonal regulation, manifesting itself simultaneously by the effect of parathormone and calcitonine in both phases of osteal regeneration. The disregulation of mineral metabolism, catabolism and anabolism processes of organic matrix causes the delay of reparative processes, intypicalness and development of fibrous tissue.

LEUCOCYTE METABOLISM IN PREGNANCY

1960 ◽  
Vol XXXV (IV) ◽  
pp. 575-584 ◽  
Author(s):  
C. Borel ◽  
J. Frei ◽  
A. Vannotti
Keyword(s):  
Alkaline Phosphatase ◽  
Oxygen Consumption ◽  
Pregnant Women ◽  
Phosphatase Activity ◽  
Alkaline Phosphatase Activity ◽  
Lactate Production ◽  
Glucose Consumption ◽  
In Pregnancy

ABSTRACT Enzymatic studies, on leucocytes of pregnant women, show an increase of the alkaline phosphatase activity and a decrease of the glucose consumption and lactate production, as well as of proteolysis. The oxygen consumption, with succinate as substrate, does not vary.

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