Early engagement with NOPSEMA

2014 ◽  
Vol 54 (2) ◽  
pp. 510
Author(s):  
Claude Cahuzac
Keyword(s):  
Joint Venture ◽  
Investment Decision ◽  
Good Communication ◽  
Central Processing ◽  
Processing Facility ◽  
Safety Case ◽  
Engagement Process ◽  
First Time ◽  
Voluntary Basis

The Ichthys LNG Project includes a central processing facility (CPF) that is the world’s largest semi-submersible platform. The Ichthys CPF is also the first semi-submersible in Australian waters. Given the novelty of the development concept, the complexity of the design, and the scale of the facilities, the Ichthys Project joint venture participants INPEX and Total wanted to gain a better understanding of what the Australian regulators would be looking for as part of the approval process prior to committing to a final investment decision (FID). On a voluntary basis, the project launched an early engagement with NOPSA (later NOPSEMA) in 2011 to review the design safety case for the CPF. This was the first time such an early engagement process had been undertaken by the regulator. A significant benefit of the early engagement process for both parties was good communication and feedback leading to the establishment of a mutually beneficial long-term relationship. The early engagement process identified no show stoppers at that stage. Feedback from the regulator was incorporated in the detailed engineering. The Ichthys Project considers that the early engagement process with NOPSEMA was positive and constructive. It contributed to an FID being taken in January 2012. INPEX continues to engage proactively with NOPSEMA.

The Ichthys LNG Project: big, bold and beautiful

2013 ◽  
Vol 53 (2) ◽  
pp. 430
Author(s):  
Antoine Serceau
Keyword(s):  
Joint Venture ◽  
Oil And Gas ◽  
Capital Expenditure ◽  
Investment Decision ◽  
Weather Conditions ◽  
Subsea Pipeline ◽  
Central Processing ◽  
Pipeline Project ◽  
Construction Activity ◽  
New Construction

The Ichthys LNG Project is one of the most complex oil and gas developments attempted. It is three mega-projects in one: an onshore project, an offshore project, and a pipeline project. The onshore project is being developed in Darwin and involves two processing trains rated to produce a total of 8.4 million tonnes of LNG per year. Offshore, the central processing facility (CPF) will feature the world's largest semi-submersible platform. A substantial floating, production storage and offtake (FPSO) vessel, designed to hold more than one million barrels of condensate, will be stationed nearby. Both the CPF and FPSO will be permanently moored in an area notorious for cyclonic weather conditions and will be designed to withstand even the most extreme weather conditions for more than four decades. An 889 km subsea pipeline will link the Ichthys Field, 200 km off the Western Australian coast, to the onshore facilities in Darwin. This represents the longest subsea pipeline in the southern hemisphere and fifth longest in the world. A final investment decision for the project was announced in January 2012. This triggered intense construction activity and created hundreds of new construction jobs in Darwin and more globally. More than 4,000 direct jobs will be created at the peak of construction. An approved capital expenditure of $US34 billion by INPEX and the Ichthys Project joint venture participants shows a tremendous commitment to Australia. Since the discovery of the gas-condensate field in 2000, the Ichthys road has been one of identifying and overcoming geographical, political, technical, physical, financial, and commercial challenges. The Ichthys Project is a global effort, drawing on worldwide expertise to overcome these challenges and work towards first gas in late 2016.

Somatic Embryogenesis and In vitro Plant Regeneration in Vigna trilobata (L.) Verd. - A Potential Pasture Legume

1970 ◽  
Vol 19 (1) ◽  
pp. 89-99
Author(s):  
K. Choudhary ◽  
M. Singh ◽  
M. S. Rathore ◽  
N. S. Shekhawat
Keyword(s):  
Somatic Embryogenesis ◽  
Growth Regulators ◽  
Somatic Embryos ◽  
Basal Medium ◽  
Long Term Study ◽  
Continuous Application ◽  
First Time ◽  
Pasture Legume

This long term study demonstrates for the first time that it is possible to propagate embryogenic Vigna trilobata and to subsequently initiate the differentiation of embryos into complete plantlets. Initiation of callus was possible on 2,4-D. Somatic embryos differentiated on modified MS basal nutrient medium with 1.0 mg/l  of 2,4-D and 0.5 mg/l  of Kn. Sustained cell division resulted in globular and heart shape stages of somatic embryos. Transfer of embryos on to a fresh modified MS basal medium with 0.5 mg/l of Kn and 0.5 mg/l of GA3 helped them to attain maturation and germination. However, the propagation of cells, as well as the differentiation of embryos, were inhibited by a continuous application of these growth regulators. For this reason, a long period on medium lacking these growth regulators was necessary before the differentiation of embryos occurred again. The consequences for improving the propagation of embryogenic cultures in Vigna species are discussed. Key words: Pasture  legume, Vigna trilobata, Globular, Heart shape, somatic embryogenesis D.O.I. 10.3329/ptcb.v19i1.4990 Plant Tissue Cult. & Biotech. 19(1): 89-99, 2009 (June)

An Evaluation of Provincial Macroeconomic Performance in Vietnam

2017 ◽  
pp. 34-47
Author(s):  
Hoi Le Quoc ◽  
Nam Pham Xuan ◽  
Tuan Nguyen Anh
Keyword(s):  
Development Strategy ◽  
Institutional Transformation ◽  
Economic Indicators ◽  
Macroeconomic Performance ◽  
Economic Development Strategy ◽  
Socio Economic Development ◽  
The Cost ◽  
Development Objectives ◽  
First Time

The study was targeted at developing a methodology for constructing a macroeconomic performance index at a provincial level for the first time in Vietnam based on 4 groups of measurements: (i) Economic indicators; (ii) oriented economic indicators; (iii) socio-economic indicators; and (iv) economic - social – institutional indicators. Applying the methodology to the 2011 - 2015 empirical data of all provinces in Vietnam, the research shows that the socio-economic development strategy implemented by those provinces did not provide balanced outcomes between growth and social objectives, sustainability and inclusiveness. Many provinces focused on economic growth at the cost of structural change, equality and institutional transformation. In contrast, many provinces were successful in improving equality but not growth. Those facts threaten the long-term development objectives of the provinces.

NEW VARIETIES OF CURRANTS AND GOOSEBERRY BREEDING PLANTS

1970 ◽  
pp. 41-46
Author(s):  
O. D. Golyaeva ◽  
O. V. Kurashev ◽  
S. D. Knyazev ◽  
А. Yu. Bakhotskaya
Keyword(s):  
Powdery Mildew ◽  
Genetic Basis ◽  
Black Currant ◽  
Leaf Spots ◽  
Agricultural Sciences ◽  
Berry Crops ◽  
New Varieties ◽  
First Time ◽  
Red Currant

The main goal of the scientific institution was and remains to improve the assortment of fruit and berry crops for the development of domestic horticulture. Black currant breeding at VNIISPK was started by A.F Tamarova and continued by the doctor of agricultural Sciences T.P.Ogoltsova and doctor of agricultural Sciences S.D. Knyazev. A long-term breeding program has been developed. The main goals of the program are to create black currant cultivars with continuous resistance to diseases, first of all powdery mildew, as wells resistance to pests, i.e. bud mite. As a result of the long-term work, over 40 black currant cultivars have been developed, 14 of them are zoned. Red currant breeding was led by the candidate of agricultural Sciences L.V. Bayanova; since 2001 the work has been continued by the candidate of agricultural Sciences O.D. Golyaeva. ‘Heinemanns Rote Spӓtlese’, the descendant of R. multiflorum Kit., was involved in the red currant breeding for the first time in Russia. On its genetic basis, a series of late maturing cultivars with long and dense racemes was created. At the Institute, in total 21cultivars of red currants have been developed, 13 of them are zoned. At present, red currant cultivars make up 25.5% of the zoned assortment in Russia. The first research on gooseberries was stated by V.P. Semakin and A.F Tamarova; since 1992 the systematic gooseberry breeding has been carried out by the candidate of agricultural Sciences O.V. Kurashev. On the basis of Grossularia robusta, we have created gooseberry forms that are resistant to powdery mildew and leaf spots. These forms are highly productive, weakly thorned, having bush habit suitable for mechanized harvest. The result of breeding activities was the transfer of 6 gooseberry cultivars to State agricultural testing: ‘Solnechny Zaychik’, ‘Nekrasovsky’, ‘Yupiter’, ‘Zemlianichny’, ‘Moryachok’ and ‘Discovery’.

scholarly journals Structure-Properties Correlation of Cross-Linked Penicillin G Acylase Crystals

Crystals ◽  
2021 ◽  
Vol 11 (4) ◽  
pp. 451
Author(s):  
Marta Kubiak ◽  
Janine Mayer ◽  
Ingo Kampen ◽  
Carsten Schilde ◽  
Rebekka Biedendieck
Keyword(s):  
Mechanical Stability ◽  
Structural Characteristics ◽  
Penicillin G ◽  
Bacillus Species ◽  
Diffusion Limitations ◽  
Small Water ◽  
Long Term Stability ◽  
Atomic Force ◽  
First Time

In biocatalytic processes, the use of free enzymes is often limited due to the lack of long-term stability and reusability. To counteract this, enzymes can be crystallized and then immobilized, generating cross-linked enzyme crystals (CLECs). As mechanical stability and activity of CLECs are crucial, different penicillin G acylases (PGAs) from Gram-positive organisms have proven to be promising candidates for industrial production of new semisynthetic antibiotics, which can be crystallized and cross-linked to characterize the resulting CLECs regarding their mechanical and catalytic properties. The greatest hardness and Young’s modulus determined by indentation with an atomic force microscope were observed for CLECs of Bacillus species FJAT-PGA CLECs (26 MPa/1450 MPa), followed by BmPGA (Priestia megaterium PGA, 23 MPa/1170 MPa) and BtPGA CLECs (Bacillus thermotolerans PGA, 11 MPa/614 MPa). In addition, FJAT- and BtPGA CLECs showed up to 20-fold higher volumetric activities compared to BmPGA CLECs. Correlation to structural characteristics indicated that a high solvent content and low number of cross-linking residues might lead to reduced stability. Furthermore, activity seems to be restricted by small water channels due to severe diffusion limitations. To the best of our knowledge, we show for the first time in this study that the entire process chain for the characterization of diverse industrially relevant enzymes can be performed at the microliter scale to discover the most important relationships and limitations.

scholarly journals Exposure to Δ9-tetrahydrocannabinol during rat pregnancy leads to impaired cardiac dysfunction in postnatal life

2021 ◽  
Author(s):  
Kendrick Lee ◽  
Steven R. Laviolette ◽  
Daniel B. Hardy
Keyword(s):  
Body Weight ◽  
Cardiac Function ◽  
Cardiac Dysfunction ◽  
Cardiac Remodelling ◽  
Long Term Effects ◽  
Catch Up ◽  
First Time ◽  
Impaired Cardiac Function ◽  
In Pregnancy

Abstract Background Cannabis use in pregnancy leads to fetal growth restriction (FGR), but the long-term effects on cardiac function in the offspring are unknown, despite the fact that fetal growth deficits are associated with an increased risk of developing postnatal cardiovascular disease. We hypothesize that maternal exposure to Δ9-tetrahydrocannabinol (Δ9-THC) during pregnancy will impair fetal development, leading to cardiac dysfunction in the offspring. Methods Pregnant Wistar rats were randomly selected and administered 3 mg/kg of Δ9-THC or saline as a vehicle daily via intraperitoneal injection from gestational days 6 to 22, followed by echocardiogram analysis of cardiac function on offspring at postnatal days 1 and 21. Heart tissue was harvested from the offspring at 3 weeks for molecular analysis of cardiac remodelling. Results Exposure to Δ9-THC during pregnancy led to FGR with a significant decrease in heart-to-body weight ratios at birth. By 3 weeks, pups exhibited catch-up growth associated with significantly greater left ventricle anterior wall thickness with a decrease in cardiac output. Moreover, these Δ9-THC-exposed offsprings exhibited increased expression of collagen I and III, decreased matrix metallopeptidase-2 expression, and increased inactivation of glycogen synthase kinase-3β, all associated with cardiac remodelling. Conclusions Collectively, these data suggest that Δ9-THC-exposed FGR offspring undergo postnatal catch-up growth concomitant with cardiac remodelling and impaired cardiac function early in life. Impact To date, the long-term effects of perinatal Δ9-THC (the main psychoactive component) exposure on the cardiac function in the offspring remain unknown. We demonstrated, for the first time, that exposure to Δ9-THC alone during rat pregnancy results in significantly smaller hearts relative to body weight. These Δ9-THC-exposed offsprings exhibited postnatal catch-up growth concomitant with cardiac remodelling and impaired cardiac function. Given the increased popularity of cannabis use in pregnancy along with rising Δ9-THC concentrations, this study, for the first time, identifies the risk of perinatal Δ9-THC exposure on early postnatal cardiovascular health.

Empowering and Directive Leadership: The Cost of Changing Styles

2021 ◽  
pp. 227853372110083
Author(s):  
Smita Mukherjee ◽  
Zubin R. Mulla
Keyword(s):  
Laboratory Experiment ◽  
Leadership Styles ◽  
Leadership Style ◽  
Affective Commitment ◽  
Team Outcomes ◽  
History Of ◽  
Satisfaction With The Leader ◽  
The Cost ◽  
First Time

We examine the cost of leaders changing between empowering and directive leadership styles on team outcomes. In a laboratory experiment, we collected data from 240 participants in 80 teams. Confederates enacted different leadership styles and led teams of participants in performing a series of tasks. When leaders changed their style from directive to empowering, teams took time to respond in terms of higher satisfaction with leader and affective commitment. However, when leaders changed their style from empowering to directive, the deterioration of satisfaction with leader and reduction in affective commitment were immediate. Moreover, teams of leaders who had been consistently directive showed higher affective commitment as compared to teams of leaders who had a history of being empowering but later shifted to being directive. First time managers can get inputs on how they should enact their leadership style and be aware that switching between styles may impose long-term costs on the team’s affective commitment and satisfaction with the leader.

scholarly journals Solubility Product of Vanadinite Pb5(VO4)3Cl at 25 °C—A Comprehensive Approach to Incongruent Dissolution Modeling

Minerals ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 135
Author(s):  
Justyna Topolska ◽  
Bartosz Puzio ◽  
Olaf Borkiewicz ◽  
Julia Sordyl ◽  
Maciej Manecki
Keyword(s):  
Nuclear Waste ◽  
Solubility Product ◽  
Geochemical Modeling ◽  
Incongruent Dissolution ◽  
Mineral Solubility ◽  
Actual Application ◽  
Universal Approach ◽  
Solubility Constant ◽  
First Time

Although vanadinite (Pb5(VO4)3Cl) occurs in abundance in various terrestrial geochemical systems of natural and anthropogenic origin and is seriously considered as a potential nuclear waste sequestering agent, its actual application is severely limited by a lack of understanding of its basic thermodynamic parameters. In this regard, the greatest challenge is posed by its incongruent dissolution, which is a pivotal hurdle for effective geochemical modeling. Our paper presents an universal approach for geochemical computing of systems undergoing incongruent dissolution which, along with unique, long-term experiments on vanadinites’ stability, allowed us to determine the mineral solubility constant. The dissolution experiments were carried out at pH = 3.5 for 12 years. Vanadinite has dissolved incongruently, continuously re-precipitating into chervetite (Pb2V2O7) with the two minerals remaining in mutual equilibrium until termination of the experiments. The empirically derived solubility constant Ksp,V,298 = 10–91.89 ± 0.05 of vanadinite was determined for the first time. The proposed modeling method is versatile and can be adopted to other mineral systems undergoing incongruent dissolution.

scholarly journals Dinosaurs in decline tens of millions of years before their final extinction

2016 ◽  
Vol 113 (18) ◽  
pp. 5036-5040 ◽  
Author(s):  
Manabu Sakamoto ◽  
Michael J. Benton ◽  
Chris Venditti
Keyword(s):  
Mass Extinction ◽  
Marked Reduction ◽  
Evolutionary Dynamics ◽  
General Pattern ◽  
Extinction Rate ◽  
Catastrophic Event ◽  
Extinction Event ◽  
Mass Extinction Event ◽  
First Time

Whether dinosaurs were in a long-term decline or whether they were reigning strong right up to their final disappearance at the Cretaceous–Paleogene (K-Pg) mass extinction event 66 Mya has been debated for decades with no clear resolution. The dispute has continued unresolved because of a lack of statistical rigor and appropriate evolutionary framework. Here, for the first time to our knowledge, we apply a Bayesian phylogenetic approach to model the evolutionary dynamics of speciation and extinction through time in Mesozoic dinosaurs, properly taking account of previously ignored statistical violations. We find overwhelming support for a long-term decline across all dinosaurs and within all three dinosaurian subclades (Ornithischia, Sauropodomorpha, and Theropoda), where speciation rate slowed down through time and was ultimately exceeded by extinction rate tens of millions of years before the K-Pg boundary. The only exceptions to this general pattern are the morphologically specialized herbivores, the Hadrosauriformes and Ceratopsidae, which show rapid species proliferations throughout the Late Cretaceous instead. Our results highlight that, despite some heterogeneity in speciation dynamics, dinosaurs showed a marked reduction in their ability to replace extinct species with new ones, making them vulnerable to extinction and unable to respond quickly to and recover from the final catastrophic event.

Intensifiers on Tyneside

2010 ◽  
Vol 31 (3) ◽  
pp. 252-287 ◽  
Author(s):  
Katie Barnfield ◽  
Isabelle Buchstaller
Keyword(s):  
Real Time ◽  
Longitudinal Analysis ◽  
Developmental Trajectories ◽  
Time Data ◽  
Longitudinal Changes ◽  
Real Time Data ◽  
Quantitative Development ◽  
First Time

We report on longitudinal changes in the system of intensification in an innovative corpus that spans five decades of dialectal speech. Our analyses allow us — for the first time in a British context — to trace the quantitative development in the variable across four generations. Longitudinal analysis across real and apparent time determines the effect of extralinguistic and intralinguistic variables on intensification in Tyneside and tests to what extent real time data corroborates trends reported from previous apparent time analyses. Long-term competition within the variable manifests itself in distinctive developmental trajectories: expansion — both proportionally within the variable as well as across adjectival categories — tends to follow one of three types of patterns, exemplified, respectively, by really, so and dead. Variant retraction, however, follows only one schema. Importantly, numerical decline in the system does not necessarily go hand in hand with a reduction in breadth of application.

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