Recent advances in the chemistry of pyridazine — an important representative of six-membered nitrogen heterocycles

2020 ◽  
Vol 89 (4) ◽  
pp. 393-429 ◽  
Author(s):  
P G Sergeev ◽  
V G Nenajdenko
Keyword(s):  
Nitrogen Heterocycles ◽  
Recent Advances

scholarly journals Recent Advances in the Application of Ring-Closing Metathesis for the Synthesis of Unsaturated Nitrogen Heterocycles

Synthesis ◽  
2019 ◽  
Vol 51 (05) ◽  
pp. 1100-1114 ◽  
Author(s):  
Emilia Groso ◽  
Corinna Schindler
Keyword(s):  
Olefin Metathesis ◽  
Nitrogen Heterocycles ◽  
Short Review ◽  
Catalyst Design ◽  
Carbene Ligands ◽  
Ring Closing Metathesis ◽  
Recent Advances ◽  
Metathesis Reactions

This short review summarizes recent advances relating to the application of ring-closing olefin-olefin and carbonyl-olefin metathesis reactions towards the synthesis of unsaturated five- and six-membered nitrogen heterocycles. These developments include catalyst modifications and reaction designs that will enable access to more complex nitrogen heterocycles.1 Introduction2 Expansion of Ring-Closing Metathesis Methods3 Evaluation of Catalyst Design4 Indenylidene Catalysts5 Unsymmetrical N-Heterocyclic Carbene Ligands6 Carbonyl-Olefin Metathesis7 Conclusions

Recent Advances in the Synthesis of Nitrogen Heterocycles Using Arenediazonium Salts as Nitrogen Sources

2020 ◽  
Vol 362 (22) ◽  
pp. 4876-4895 ◽  
Author(s):  
Jidan Liu ◽  
Jinyuan Jiang ◽  
Liyao Zheng ◽  
Zhao‐Qing Liu
Keyword(s):  
Nitrogen Heterocycles ◽  
Nitrogen Sources ◽  
Recent Advances ◽  
Arenediazonium Salts

Recent advances in the synthesis of nitrogen heterocycles via radical cascade reactions using isonitriles as radical acceptors

2015 ◽  
Vol 44 (11) ◽  
pp. 3505-3521 ◽  
Author(s):  
Bo Zhang ◽  
Armido Studer
Keyword(s):  
Nitrogen Heterocycles ◽  
Cascade Reactions ◽  
Insertion Reactions ◽  
Recent Advances ◽  
Radical Cascade

Radical isonitrile insertion reactions are highly valuable for the construction of N-containing heterocycles such as phenanthridines, quinolines, isoquinolines, quinoxalines and indoles.

scholarly journals Recent advances in the synthesis of bridgehead (or ring-junction) nitrogen heterocycles via transition metal-catalyzed C–H bond activation and functionalization

2020 ◽  
Vol 7 (19) ◽  
pp. 3067-3099
Author(s):  
Biao Nie ◽  
Wanqing Wu ◽  
Yingjun Zhang ◽  
Huanfeng Jiang ◽  
Ji Zhang
Keyword(s):  
Transition Metal ◽  
Bond Activation ◽  
Nitrogen Heterocycles ◽  
Fused Heterocycles ◽  
Recent Advances ◽  
Ring Junction ◽  
Transition Metal Catalyzed ◽  
Metal Catalyzed ◽  
Bridgehead Nitrogen

An update on recent advances in the synthesis of bridgehead nitrogen fused heterocycles via transition metal-catalyzed C–H activation and functionalization is reported.

Recent advances in the asymmetric synthesis of pharmacology-relevant nitrogen heterocycles via stereoselective aza-Michael reactions

2019 ◽  
Vol 17 (15) ◽  
pp. 3670-3708 ◽  
Author(s):  
Maxim G. Vinogradov ◽  
Olga V. Turova ◽  
Sergei G. Zlotin
Keyword(s):  
Asymmetric Synthesis ◽  
Michael Reaction ◽  
Nitrogen Heterocycles ◽  
Michael Reactions ◽  
Naturally Occurring ◽  
Recent Advances

In this review, recent applications of a stereoselective aza-Michael reaction for asymmetric synthesis of naturally occurring N-containing heterocyclic scaffolds and their usefulness to pharmacology are summarized.

Recent Advances in Catalytic Enantioselective Synthesis of Pyrazolones with a Tetrasubstituted Stereogenic Center at the 4-Position

Synthesis ◽  
2020 ◽  
Vol 53 (02) ◽  
pp. 215-237
Author(s):  
José R. Pedro ◽  
Carlos Vila ◽  
Laura Carceller-Ferrer ◽  
Gonzalo Blay
Keyword(s):  
Biological Activity ◽  
Asymmetric Synthesis ◽  
Nitrogen Heterocycles ◽  
Enantioselective Synthesis ◽  
Great Success ◽  
Pharmaceutical Drugs ◽  
Quaternary Carbon ◽  
Recent Advances ◽  
Excellent Research ◽  
Stereogenic Center

AbstractPyrazolone [2,4-dihydro-3H-pyrazol-4-one] represents one of the most important five-membered nitrogen heterocycles which is present in numerous pharmaceutical drugs and molecules with biological activity. Recently, many catalytic methodologies for the asymmetric synthesis of chiral pyrazolones have been established with great success, specially, for the synthesis of pyrazolones bearing a tetrasubstituted stereocenter at C-4. This review summarizes these excellent research studies since 2018, including representative examples and some mechanistic pathways explaining the observed stereochemistry.1 Introduction2 Catalytic Enantioselective Synthesis of Chiral Pyrazolones with a Full Carbon Tetrasubstituted Stereocenter at C-43 Catalytic Enantioselective Synthesis of Chiral Pyrazolones with a Quaternary Carbon Stereocenter at C-4 bearing a Heteroatom4 Catalytic Enantioselective Synthesis of Chiral Spiropyrazolones5 Conclusion

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