Leptin-resistant obese mice have paradoxically low biliary cholesterol saturation

Surgery ◽  
2003 ◽  
Vol 134 (2) ◽  
pp. 372-377 ◽  
Author(s):  
Khoi Q. Tran ◽  
Shannon J. Graewin ◽  
Deborah A. Swartz-Basile ◽  
Attila Nakeeb ◽  
Carol L. Svatek ◽  
...  
Keyword(s):  
Obese Mice ◽  
Biliary Cholesterol ◽  
Cholesterol Saturation

Enrichment of bile with tauroursodeoxycholic acid and biliary cholesterol saturation in hamsters

1982 ◽  
Vol 243 (5) ◽  
pp. G424-G427
Author(s):  
B. Handelsman ◽  
G. Bonorris ◽  
J. W. Marks ◽  
L. J. Schoenfield
Keyword(s):  
Ursodeoxycholic Acid ◽  
Saturation Index ◽  
Saturation Indices ◽  
Biliary Cholesterol ◽  
Molar Percentage ◽  
Lithogenic Diet ◽  
Cholesterol Saturation ◽  
Before And After ◽  
Ketamine Anesthesia ◽  
Lower Saturation

Three groups of golden Syrian hamsters were fed equimolar amounts of taurine-conjugated ursodeoxycholic acid (TUDCA) or unconjugated ursodeoxycholic acid (UDCA) with or without excess taurine for 2 wk. They also received a lithogenic diet composed of standard rodent chow containing ethynylestradiol and increased cholesterol. Bile was obtained from the gallbladder after ketamine anesthesia and analyzed for biliary lipids. The percentage of biliary UDCA was higher with TUDCA (38.5 +/- 3.7) than with UDCA plus taurine (26.5 +/- 2.0, P less than 0.01). The glycine-to-taurine ratio of biliary UDCA conjugates was lower with TUDCA (0.9 +/- 0.1) than with UDCA plus taurine (2.1 +/- 0.2, P less than 0.01) and was highest with UDCA without taurine (4.1 +/- 0.1, P less than 0.01). Biliary cholesterol (molar percentage) and the cholesterol saturation indices with or without correction for UDCA-rich bile were significantly lower with TUDCA than with unconjugated UDCA with or without added taurine. In conclusion, administration for 2 wk of TUDCA, compared with an equimolar amount of unconjugated UDCA plus taurine, produced in the bile of hamsters a higher percentage of UDCA, a lower glycine-to-taurine ratio of UDCA conjugates, and a lower saturation index before and after adjustment for UDCA-rich bile.

scholarly journals Dietary N-3 polyunsaturated fatty acids decrease biliary cholesterol saturation in gallstone disease

Hepatology ◽  
1992 ◽  
Vol 16 (4) ◽  
pp. 960-967 ◽  
Author(s):  
Frieder Berr ◽  
Joseph Holl ◽  
Dieter Jüngst ◽  
Sven Fischer ◽  
Werner O. Richter ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Gallstone Disease ◽  
Biliary Cholesterol ◽  
Cholesterol Saturation

Biliary Cholesterol Saturation and Weight Reduction – Effects of Fasting and Low Calorie Diet

Digestion ◽  
1981 ◽  
Vol 21 (1) ◽  
pp. 44-49 ◽  
Author(s):  
G. Schlierf ◽  
B. Schellenberg ◽  
A. Stiehl ◽  
P. Czygan ◽  
P. Oster
Keyword(s):  
Weight Reduction ◽  
Biliary Cholesterol ◽  
Low Calorie ◽  
Low Calorie Diet ◽  
Cholesterol Saturation ◽  
Calorie Diet
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