Biliary Cholesterol Saturation and Weight Reduction – Effects of Fasting and Low Calorie Diet

Digestion ◽  
1981 ◽  
Vol 21 (1) ◽  
pp. 44-49 ◽  
Author(s):  
G. Schlierf ◽  
B. Schellenberg ◽  
A. Stiehl ◽  
P. Czygan ◽  
P. Oster
Keyword(s):  
Weight Reduction ◽  
Biliary Cholesterol ◽  
Low Calorie ◽  
Low Calorie Diet ◽  
Cholesterol Saturation ◽  
Calorie Diet

Impact of a 6-week very low-calorie diet and weight reduction on the serum and fecal metabolome of overweight subjects

2014 ◽  
Vol 240 (3) ◽  
pp. 583-594 ◽  
Author(s):  
Mette S. Schmedes ◽  
Christian C. Yde ◽  
Ulla Svensson ◽  
Janet Håkansson ◽  
Sanmohan Baby ◽  
...  
Keyword(s):  
Weight Reduction ◽  
Very Low Calorie Diet ◽  
Low Calorie ◽  
Low Calorie Diet ◽  
Calorie Diet ◽  
Overweight Subjects

scholarly journals SUN-682 Type Two Diabetes Patient in Remission After Twelve Years of Diagnosis

2020 ◽  
Vol 4 (Supplement_1) ◽  
Author(s):  
Amna Ali Shaghouli ◽  
Rola Aranky
Keyword(s):  
Type 2 Diabetes ◽  
Weight Loss ◽  
Beta Cell ◽  
Weight Reduction ◽  
Team Approach ◽  
Very Low Calorie Diet ◽  
Low Calorie ◽  
Low Calorie Diet ◽  
Calorie Diet

Abstract Introduction Type 2 diabetes (T2D) has been defined as a lifelong condition which is inevitably progressive.1 The idea that beta cell function certainly declines with time in diabetic people who have developed T2D has been definitively disproven.2 It has been recognised that the processes that cause T2D can be reversed and T2D remission can be achieved.2 Many studies show that, by changing life style dramatically, controlling diabetes can improve significantly and a significant proportion of patients can also reduce or come off their glucose-lowering therapies.3 This has been formally proven in DIRECT, with clear evidence of gradual continuing improvement in beta cell functional capacity over at least 12 months.4 Remission was linked to weight loss, as two third of those who lost more than 10kg were in remission after two years.4 Methods A case study was done on a 66 years old male, who is diabetic for the last 12 years, with other comorbidities: hypertension and hypercholesterolemia. He presented with Hemoglobin A1C (HbA1c) of 7.4% with BMI of 37.7 kg/m2 on four oral hypoglycaemic agents and basal insulin of 20 units per day. His treatment was changed by adding Glucagon-like peptide-1 receptor agonists (GLP-1 RA) for better glycemic control and weight reduction in a setting of a multidisciplinary team approach, including endocrinologist, diabetes educator, dietitian and physical trainer. Results Over the last one year and two months, patient was able to stop all his diabetes medication including GLP-1 RA. Over three years follow ups patient achieved weight reduction of 17.3% with HbA1c of 6.5% and additional other metabolic factor benefits. Conclusion Even with 12 years of diabetes, reversibility of T2D can still be achieved with weight reduction of over 15%. We will wait for another 10 months to reconfirm our data for two years remission. References 1. Steven S, Taylor R. Restoring normoglycaemia by use of a very low calorie diet in long-and short-duration Type 2 diabetes. Diabetic Medicine. 2015 Sep;32(9):1149-55. 2. Nagi D, Hambling C, Taylor R. Remission of type 2 diabetes: a position statement from the Association of British Clinical Diabetologists (ABCD) and the Primary Care Diabetes Society (PCDS). British Journal of Diabetes. 2019 Jun 27;19(1):73-6. 3. Wing RR, Blair E, Marcus M, Epstein LH, Harvey J. Year-long weight loss treatment for obese patients with type II diabetes: does including an intermittent very-low-calorie diet improve outcome?. The American journal of medicine. 1994 Oct 1;97(4):354-62. 4. Taylor R, Al-Mrabeh A, Zhyzhneuskaya S, Peters C, Barnes AC, Aribisala BS, Hollingsworth KG, Mathers JC, Sattar N, Lean ME. Remission of human type 2 diabetes requires decrease in liver and pancreas fat content but is dependent upon capacity for β cell recovery. Cell metabolism. 2018 Oct 2;28(4):547-56.

scholarly journals Effect of Weight Reduction with Dietary Intervention on Arterial Distensibility and Endothelial Function in Obese Men

Angiology ◽  
2008 ◽  
Vol 60 (3) ◽  
pp. 351-357 ◽  
Author(s):  
Asako Miyaki ◽  
Seiji Maeda ◽  
Mutsuko Yoshizawa ◽  
Maiko Misono ◽  
Yoko Saito ◽  
...  
Keyword(s):  
Endothelial Function ◽  
Weight Reduction ◽  
Dietary Intervention ◽  
Arterial Compliance ◽  
Aortic Pulse Wave Velocity ◽  
Stiffness Index ◽  
Arterial Distensibility ◽  
Low Calorie ◽  
Low Calorie Diet ◽  
Calorie Diet

Obesity and reduction in central arterial distensibility, respectively, have been identified as powerful and independent risk factors for cardiovascular disease. However, the effect of weight reduction on central arterial function in obese subjects has not yet been clarified. We investigated whether low-calorie diet-induced weight reduction affects central arterial distensibility and endothelial function in middle-aged obese men. Twelve obese men (age: 45 ± 2 yrs, BMI: 30±1 kg/m2) completed a 12-week dietary intervention. Caloric restriction induced significantly weight loss and decrease in BMI. After the program, carotid arterial compliance significantly increased and β-stiffness index and aortic pulse-wave velocity remarkably decreased. Concentrations of plasma endothelin-1 (ET-1) significantly decreased and plasma nitric oxide (NO) markedly increased after the program. Weight reduction by low-calorie diet in obese men increases central arterial distensibility, which may contribute to the improvement in endothelial function, as noted by a decrease in ET-1 and an increase in NO.

Changes in Serum Lipids and Lecithin: Cholesterol Acyltransferase Enzyme during 1 Week Weight Reduction of Women on a Low-Calorie Diet

Enzyme ◽  
1983 ◽  
Vol 29 (3) ◽  
pp. 160-166 ◽  
Author(s):  
Eino Hietanen ◽  
Matti Laitinen ◽  
Esa Ahonen ◽  
Jukka Marniemi ◽  
Unto Nousiainen
Keyword(s):  
Weight Reduction ◽  
Serum Lipids ◽  
Cholesterol Acyltransferase ◽  
Low Calorie ◽  
Lecithin Cholesterol Acyltransferase ◽  
Low Calorie Diet ◽  
Calorie Diet
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