Prognostic value and quality of life in patients with normal rest thallium-201/stress technetium 99m-tetrofosmin dual-isotope myocardial SPECT

2000 ◽  
Vol 7 (4) ◽  
pp. 333-341 ◽  
Author(s):  
R GROUTARS ◽  
J VERZIJLBERGEN ◽  
A MULLER ◽  
C ASCOOP ◽  
M TIELVANBUUL ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Prognostic Value ◽  
Thallium 201 ◽  
Myocardial Spect ◽  
Dual Isotope ◽  
Technetium 99M ◽  
Technetium 99M Tetrofosmin

Detection of Occult Thymoma During Exercise Thallium 201, Technetium 99m Tetrofosmin Imaging for Coronary Artery Disease

CHEST Journal ◽  
2000 ◽  
Vol 118 (2) ◽  
pp. 550-551 ◽  
Author(s):  
Douglas E. Paull ◽  
Joan Graham ◽  
Joan Forgetta ◽  
Thomas Turissini ◽  
Bruce Saidman
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Thallium 201 ◽  
Technetium 99M ◽  
Technetium 99M Tetrofosmin ◽  
Artery Disease

Prognostic Value of Patient Knowledge of Cancer on Quality of Life in Advanced Lung Cancer During Chemotherapy

2018 ◽  
Vol 35 (1) ◽  
pp. 93-99
Author(s):  
Krzysztof Adamowicz ◽  
Justyna Janiszewska ◽  
Monika Lichodziejewska-Niemierko
Keyword(s):  
Quality Of Life ◽  
Lung Cancer ◽  
Prognostic Value ◽  
Advanced Lung Cancer ◽  
Patient Knowledge ◽  
Knowledge Of Cancer

Abstract 5818: Stress Thallium-201/Rest Tc-99m Sequential Dual Isotope High-Speed Myocardial Perfusion Imaging

Circulation ◽  
2008 ◽  
Vol 118 (suppl_18) ◽  
Author(s):  
Daniel S Berman ◽  
Sean W Hayes ◽  
Arik Wolak ◽  
Xingping Kang ◽  
Louise E Thomson ◽  
...  
Keyword(s):  
Myocardial Perfusion Imaging ◽  
Myocardial Perfusion ◽  
Perfusion Imaging ◽  
High Speed ◽  
Invasive Coronary Angiography ◽  
Thallium 201 ◽  
Imaging Protocol ◽  
Dual Isotope ◽  
Artery Disease

Recent advances in gamma camera technology are providing opportunities for novel high-speed myocardial perfusion imaging (HS-MPI) protocols. We aimed to develop and evaluate a stress thallium-201 (Tl-201) and rest Tc-99m sestamibi or tetrofosmin imaging protocol that could reduce imaging time and radiation burden. Methods: We studied 410 consecutive patients undergoing exercise or pharmacologic low-dose stress Tl-201 HS-MPI (4 min/acquisition) in the semi-upright and supine positions (D-SPECT, Spectrum-Dynamics) followed by rest Tc-99m sestamibi (n= 139) or tetrofosmin (n= 271) with immediate post-injection rest imaging. Of 330 patients with no known coronary artery disease (CAD), 29 patients also underwent invasive coronary angiography (ICA) or coronary computed tomography angiography (CCTA) within a three month period and 36 had a < 5% pre-test likelihood of CAD (LLk). Despite low injected doses [Tl-201 (2.2± 0.3 mCi) and Tc-99m sestamibi or tetrofosmin (8.9± 2.4 mCi), the 3 acquisition MPI protocol (2 stress/1 rest) was accomplished < 20 minutes. The quality of stress and resting image was good to excellent in >96% of cases; importantly, no or minor extracardiac activity was seen on 99% of stress and 93% of rest images. HS-MPI was nondiagnostic or uninterpretable in only 2/410 patients. In the 29 patients with CCTA or ICA, the sensitivity and specificity for the detection of ≥70% stenosis were 73% and 89%, respectively, and in 15 patients with ICA, the sensitivity was 89%. The normalcy rate in the LLk group was 100%. A fast stress Tl-201/rest Tc-99m HS-MPI protocol offers promise as a time-efficient, low radiation dose method, in which the superior qualities of Tl-201 for stress imaging and of Tc-99m agents for rest imaging can be utilized.

P175 Prognostic value of 99mTc-ECD brain perfusion SPECT in patients with atrial fibrillation and dementia

2020 ◽  
Vol 41 (Supplement_1) ◽  
Author(s):  
H Hashimoto ◽  
R Nakanishi ◽  
S Mizumura ◽  
Y Hashimoto ◽  
Y Okamura ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Atrial Fibrillation ◽  
High Risk ◽  
Prognostic Value ◽  
Cox Model ◽  
Brain Perfusion ◽  
Z Score ◽  
Brain Perfusion Spect ◽  
Perfusion Spect

Abstract Background Atrial fibrillation (AF) is the most common cardiac arrhythmia, and those afflicted have reduced quality of life, functional status, and cardiac performance. The patients with AF have a high risk of coronary heart disease and cardiovascular disease. Although the prevalence of AF is increasing, cognitive disorders are also on the rise in tandem with the aging of the population. The patients with dementia have also experienced lower the quality of life and have increased mortality. Technetium 99m ECD brain perfusion single photon emission computed tomography (99mTc-ECD brain perfusion SPECT) is a useful modality for diagnosing dementia and identifying high risk patients with mild cognitive impairment. However, there are few reports about the relationship between the value of Z score calculated by 99mTc-ECD brain perfusion SPECT and prognosis of patients with AF and dementia. Purpose The aim of this study was to evaluate the prognostic values of brain perfusion using 99mTc-ECD SPECT in patients with AF and dementia. Methods Among 405 consecutive patients who were diagnosed as AF in cardiac outpatients and subsequently diagnosed as dementia using Mini-Mental State Examination by neurologists or psychiatrists, we identified 170 patients (81 ± 10 years) who underwent 99mTc-ECD brain perfusion SPECT for the current study. Of those, 73, 73, and 24 were diagnosed as Alzheimer’s dementia (AD), vascular dementia (VD), and non-specified dementia respectively. Multivariate Cox model was used to assess if higher Z score by 99mTc-ECD brain perfusion SPECT and clinical parameters were associated with major adverse cardiovascular events (MACE) including cardiac death, myocardial infarction, hospitalization for heart failure, and stroke. Sub-analyses of multivariate Cox models by AD or VD were also assessed. The cut-off values of Z score were determined using area under the curve by a receiver operating characteristic analysis based on MACE occurrences. Results During a mean follow-up of 1258 ± 1044 days, 62 MACE occurred. There was not significant difference of MACE between AD and VD (33%, vs. 44%, p = 0.153). By multivariable Cox model, the higher Z score of temporal-occipital-pariental lobe was associated with increased MACE compared to the lower group (HR 2.521, 95% CI 1.465–4.337, p &lt; 0.001). In a sub-analysis of patients with AD, Z score was the most significant prognostic factor for MACE (HR 3.969, 95% CI 1.374–11.468, p = 0.011). The similar trend was observed in those with VD (HR 2.247, 95% CI 1.028–4.913, p = 0.043). Conclusion: This study demonstrated that the Z score of temporal-occipital-pariental lobe by 99mTc-ECD brain perfusion SPECT could be a potential prognostic value among patients with AF and dementia, regardless of type of dementia.

Prognostic Value of Changes in Health-Related Quality of Life Scores During Curative Treatment for Esophagogastric Cancer

2010 ◽  
Vol 28 (10) ◽  
pp. 1666-1670 ◽  
Author(s):  
Therese Djärv ◽  
Chris Metcalfe ◽  
Kerry N.L. Avery ◽  
Pernilla Lagergren ◽  
Jane M. Blazeby
Keyword(s):  
Quality Of Life ◽  
Physical Function ◽  
Prognostic Value ◽  
Curative Treatment ◽  
Health Related Quality ◽  
Risk Of Death ◽  
Esophagogastric Cancer ◽  
Related Quality ◽  
Health Related

Purpose Accumulating evidence suggests that health-related quality of life (HRQL) data before treatment predict survival, but the prognostic value of changes in HRQL scores after treatment is unknown. The aim of this study was to explore whether changes in HRQL scores in esophagogastric cancer predict survival. Patients and Methods Consecutive patients undergoing curative treatment completed HRQL questionnaires (EORTC QLQ-C30) at baseline and after six months and were followed up for at least five years. Cox proportional hazard models with adjustments assessed associations between baseline HRQL and survival and between changes in HRQL before and after treatment and survival. Results Overall, 216 patients initiated curative therapy, of whom169 completed treatment and survived 6 months. Of these, 132 (7%) had two complete HRQL assessments. Analyses adjusted for age, sex, performance status, tumor stage, and disease site revealed that a 10-point poorer dyspnea score at baseline was significantly associated with an 18% higher risk of death. Additional analyses to adjust for baseline HRQL and treatment showed that a 10-point change in physical function (hazard ratio [HR], 0.85; 95% CI, 0.76 to 0.96; P = .007), pain (HR, 1.20; 95% CI, 1.09 to 1.33; P < .001), and fatigue (HR, 1.16; 95% CI, 1.04 to 1.30; P = .009) scores was associated with better survival. Conclusion This exploratory study found longer survival beyond the 6 months after starting treatment to be associated with fewer problems with dyspnea before treatment and better recovery of physical function, pain, and fatigue after treatment. More research to confirm these findings and understand the results is needed.

Attenuation-corrected rest thallium-201/stress technetium 99m sestamibi myocardial SPECT in normals*

1998 ◽  
Vol 5 (1) ◽  
pp. 48-55 ◽  
Author(s):  
I MATSUNARI ◽  
G BONING ◽  
S ZIEGLER ◽  
I KOSA ◽  
S NEKOLLA ◽  
...  
Keyword(s):  
Thallium 201 ◽  
Myocardial Spect ◽  
Technetium 99M Sestamibi ◽  
Technetium 99M ◽  
Attenuation Corrected

Health-Related Quality of Life As a Survival Predictor for Patients With Localized Head and Neck Cancer Treated With Radiation Therapy

2009 ◽  
Vol 27 (18) ◽  
pp. 2970-2976 ◽  
Author(s):  
François Meyer ◽  
André Fortin ◽  
Michel Gélinas ◽  
Abdenour Nabid ◽  
François Brochet ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Radiation Therapy ◽  
Head And Neck ◽  
Prognostic Value ◽  
Health Related Quality ◽  
Related Quality ◽  
Eortc Qlq C30 ◽  
Health Related ◽  
Eortc Qlq

Purpose To assess the added prognostic value for overall survival (OS) of baseline health-related quality of life (HRQOL) and of early changes in HRQOL among patients with localized head and neck cancer (HNC) treated with radiation therapy. Patients and Methods All 540 patients with HNC who participated in a randomized trial completed two HRQOL instruments before radiation therapy: the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30) and the Head and Neck Radiotherapy Questionnaire. Six months after the end of radiation therapy, 497 trial participants again completed the two HRQOL instruments. During the follow-up, 179 deaths were observed. Multivariate Cox proportional hazards models were used to test whether HRQOL variables, baseline and change, provided additional prognostic value beyond recognized prognostic factors. Results The baseline EORTC QLQ-C30 physical functioning (PF) score was an independent predictor of OS. The hazard ratio (HR) associated with a 10-point increment in baseline PF was 0.87 (95% CI, 0.81 to 0.94). In multivariate models, the change in HRQOL was significantly associated with OS for most HRQOL dimensions. Among these, PF change was the strongest predictor. The magnitude of the association between PF change and survival decreased over time. At 1 year, the HR associated with a positive PF change of 10 points was 0.75 (95% CI, 0.68 to 0.83). After PF is taken into account, no other HRQOL variable was associated with survival. Conclusion Our findings indicate that both baseline PF and PF change provide added prognostic value for OS beyond established predictors in patients with HNC. Assessing HRQOL could help better predict survival of cancer patients.

scholarly journals Prognostic value of changes in quality of life scores in prostate cancer

BMC Urology ◽  
2013 ◽  
Vol 13 (1) ◽  
Author(s):  
Digant Gupta ◽  
Donald P Braun ◽  
Edgar D Staren
Keyword(s):  
Quality Of Life ◽  
Prostate Cancer ◽  
Prognostic Value
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