The Prognostic Value of Measuring Health-Related Quality of Life in Hospice Patients

2007 ◽  
Vol 10 (3) ◽  
pp. 696-704 ◽  
Author(s):  
Thomas E. Elliott ◽  
Jeanette A. Palcher
Keyword(s):  
Quality Of Life ◽  
Prognostic Value ◽  
Health Related Quality ◽  
Hospice Patients ◽  
Related Quality ◽  
Health Related

Prognostic Value of Changes in Health-Related Quality of Life Scores During Curative Treatment for Esophagogastric Cancer

2010 ◽  
Vol 28 (10) ◽  
pp. 1666-1670 ◽  
Author(s):  
Therese Djärv ◽  
Chris Metcalfe ◽  
Kerry N.L. Avery ◽  
Pernilla Lagergren ◽  
Jane M. Blazeby
Keyword(s):  
Quality Of Life ◽  
Physical Function ◽  
Prognostic Value ◽  
Curative Treatment ◽  
Health Related Quality ◽  
Risk Of Death ◽  
Esophagogastric Cancer ◽  
Related Quality ◽  
Health Related

Purpose Accumulating evidence suggests that health-related quality of life (HRQL) data before treatment predict survival, but the prognostic value of changes in HRQL scores after treatment is unknown. The aim of this study was to explore whether changes in HRQL scores in esophagogastric cancer predict survival. Patients and Methods Consecutive patients undergoing curative treatment completed HRQL questionnaires (EORTC QLQ-C30) at baseline and after six months and were followed up for at least five years. Cox proportional hazard models with adjustments assessed associations between baseline HRQL and survival and between changes in HRQL before and after treatment and survival. Results Overall, 216 patients initiated curative therapy, of whom169 completed treatment and survived 6 months. Of these, 132 (7%) had two complete HRQL assessments. Analyses adjusted for age, sex, performance status, tumor stage, and disease site revealed that a 10-point poorer dyspnea score at baseline was significantly associated with an 18% higher risk of death. Additional analyses to adjust for baseline HRQL and treatment showed that a 10-point change in physical function (hazard ratio [HR], 0.85; 95% CI, 0.76 to 0.96; P = .007), pain (HR, 1.20; 95% CI, 1.09 to 1.33; P < .001), and fatigue (HR, 1.16; 95% CI, 1.04 to 1.30; P = .009) scores was associated with better survival. Conclusion This exploratory study found longer survival beyond the 6 months after starting treatment to be associated with fewer problems with dyspnea before treatment and better recovery of physical function, pain, and fatigue after treatment. More research to confirm these findings and understand the results is needed.

Health-Related Quality of Life As a Survival Predictor for Patients With Localized Head and Neck Cancer Treated With Radiation Therapy

2009 ◽  
Vol 27 (18) ◽  
pp. 2970-2976 ◽  
Author(s):  
François Meyer ◽  
André Fortin ◽  
Michel Gélinas ◽  
Abdenour Nabid ◽  
François Brochet ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Radiation Therapy ◽  
Head And Neck ◽  
Prognostic Value ◽  
Health Related Quality ◽  
Related Quality ◽  
Eortc Qlq C30 ◽  
Health Related ◽  
Eortc Qlq

Purpose To assess the added prognostic value for overall survival (OS) of baseline health-related quality of life (HRQOL) and of early changes in HRQOL among patients with localized head and neck cancer (HNC) treated with radiation therapy. Patients and Methods All 540 patients with HNC who participated in a randomized trial completed two HRQOL instruments before radiation therapy: the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire C30 (EORTC QLQ-C30) and the Head and Neck Radiotherapy Questionnaire. Six months after the end of radiation therapy, 497 trial participants again completed the two HRQOL instruments. During the follow-up, 179 deaths were observed. Multivariate Cox proportional hazards models were used to test whether HRQOL variables, baseline and change, provided additional prognostic value beyond recognized prognostic factors. Results The baseline EORTC QLQ-C30 physical functioning (PF) score was an independent predictor of OS. The hazard ratio (HR) associated with a 10-point increment in baseline PF was 0.87 (95% CI, 0.81 to 0.94). In multivariate models, the change in HRQOL was significantly associated with OS for most HRQOL dimensions. Among these, PF change was the strongest predictor. The magnitude of the association between PF change and survival decreased over time. At 1 year, the HR associated with a positive PF change of 10 points was 0.75 (95% CI, 0.68 to 0.83). After PF is taken into account, no other HRQOL variable was associated with survival. Conclusion Our findings indicate that both baseline PF and PF change provide added prognostic value for OS beyond established predictors in patients with HNC. Assessing HRQOL could help better predict survival of cancer patients.

scholarly journals Differences in and Prognostic Value of Quality of Life Data in Rectal Cancer Patients with and without Distant Metastases

Healthcare ◽  
2020 ◽  
Vol 9 (1) ◽  
pp. 1
Author(s):  
Fabian Frank ◽  
Markus Hecht ◽  
Florian Loy ◽  
Sandra Rutzner ◽  
Rainer Fietkau ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Rectal Cancer ◽  
Weight Loss ◽  
Prognostic Value ◽  
Distant Metastases ◽  
Health Related Quality ◽  
Life Data ◽  
Related Quality ◽  
Health Related

(1) Background: Individualization of treatment is a major challenge in oncology and requires a variety of predictive and prognostic parameters. In addition to tumor biology analyses, baseline health-related quality of life might be a valid tool to predict overall survival. This study was conducted to evaluate the prognostic relevance of baseline quality of life data in patients with rectal cancer. In this context, differences between patients with and without distant metastases were of particular interest. (2) Methods: Our cohort included 258 patients with rectal cancer treated in the radiotherapy department of the University Hospital Erlangen. Patients completed the European Organisation for Research and Treatment of Cancer (EORTC) core quality of life questionnaire (QLQ C30) and colorectal cancer questionnaire (CR38). Clinical and survival data were provided by the Gießener Tumor Documentation System (GTDS) of the Comprehensive Cancer Center Erlangen-EMN (CCC, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany). Statistical analyses were performed using Kaplan–Meier analyses and univariate and multivariate Cox regression. (3) Results: A cohort of 258 patients with rectal adenocarcinoma was analyzed including 50 patients (19.4%) with metastatic disease. No differences were observed between patients with and without distant metastases in most areas of quality of life studied, with the exception of physical function, loss of appetite, chemotherapy side effects and weight loss. Gender, baseline physical function, sexual function, diarrhea, and weight loss over time had a prognostic value in the entire cohort. Appetite loss was an additional prognostic parameter in patients with distant metastases. (4) Conclusions: The quality of life of patients with metastatic disease differed only slightly from non-metastatic patients. Health-related quality of life data provide prognostic information for patients with rectal cancer.

The prognostic value of health-related quality of life in patients with Chagas heart disease

2018 ◽  
Vol 28 (1) ◽  
pp. 67-72 ◽  
Author(s):  
Henrique Silveira Costa ◽  
Márcia Maria Oliveira Lima ◽  
Pedro Henrique Scheidt Figueiredo ◽  
Ana Thereza Chaves ◽  
Maria Carmo Pereira Nunes ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Heart Disease ◽  
Prognostic Value ◽  
Health Related Quality ◽  
Related Quality ◽  
Health Related ◽  
Chagas Heart Disease ◽  
Value Of Health
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