scholarly journals Single-molecule-resolution ultrafast near-field optical microscopy via plasmon lifetime extension

2021 ◽  
Vol 118 (24) ◽  
pp. 241103
Author(s):  
Rasim Volga Ovali ◽  
Ramazan Sahin ◽  
Alpan Bek ◽  
Mehmet Emre Tasgin
Keyword(s):  
Optical Microscopy ◽  
Single Molecule ◽  
Near Field ◽  
Lifetime Extension

Alterations of Single Molecule Fluorescence Lifetimes in Near-Field Optical Microscopy

Science ◽  
1994 ◽  
Vol 265 (5170) ◽  
pp. 364-367 ◽  
Author(s):  
W. P. Ambrose ◽  
P. M. Goodwin ◽  
R. A. Keller ◽  
J. C. Martin
Keyword(s):  
Optical Microscopy ◽  
Single Molecule ◽  
Near Field ◽  
Fluorescence Lifetimes ◽  
Single Molecule Fluorescence

Single Molecule Nanoparticles of the Conjugated Polymer MEH−PPV, Preparation and Characterization by Near-Field Scanning Optical Microscopy

2005 ◽  
Vol 109 (18) ◽  
pp. 8543-8546 ◽  
Author(s):  
Craig Szymanski ◽  
Changfeng Wu ◽  
Joseph Hooper ◽  
Mary Alice Salazar ◽  
Alejandro Perdomo ◽  
...  
Keyword(s):  
Optical Microscopy ◽  
Single Molecule ◽  
Conjugated Polymer ◽  
Near Field ◽  
Scanning Optical Microscopy ◽  
Near Field Scanning

Near-field optical microscopy/spectroscopy of discrete quantum emitters

1994 ◽  
Vol 52 ◽  
pp. 1060-1061
Author(s):  
E. Betzig
Keyword(s):  
Optical Microscopy ◽  
Semiconductor Lasers ◽  
Data Storage ◽  
Single Molecule ◽  
Near Field ◽  
Close Proximity ◽  
Excitation Volume ◽  
Scanning Optical Microscopy ◽  
Quantum Emitters

A subwavelength sized source or detector of visible light can be raster scanned in close proximity to the surface of a sample to generate images at a resolution well beyond the classical diffractional limit. Applications of the resultant technique, near-field scanning optical microscopy (NSOM), include fluorescence imaging of fixed cells, mode profiling of semiconductor lasers, and high density magnetooptic data storage. The focus of this presentation, however, will be on the more recent use of NSOM in the identification and characterization of discrete quantum emitters from within an ensemble.Two such systems will be discussed. The first involves the detection and characterization of single fluorescent molecules. The usual difficulty with single molecule detection is not the inherently weak luminescence signal from each molecule, but rather the large background from impurity luminescence and Raman scattering within the excitation volume. NSOM greatly reduces this volume and hence the resultant background, yielding sensitivity of 0.005 molecules.

Probing Biological Samples with Near-Field Optics

2000 ◽  
Vol 6 (S2) ◽  
pp. 826-827
Author(s):  
Sarah A. Vickery ◽  
Christopher W. Hollars ◽  
Robert C. Dunn
Keyword(s):  
Optical Microscopy ◽  
Light Source ◽  
Electric Fields ◽  
Spatial Resolution ◽  
Single Molecule ◽  
Lipid Membranes ◽  
Near Field ◽  
Level Structure ◽  
Sample Surface ◽  
Model Lipid Membranes

Near-field scanning optical microscopy (NSOM) is an emerging optical technique capable of probing samples at the nanometric level. With the NSOM technique, high spatial resolution is achieved by scanning a small light source (or collector) close to a sample surface. The light source is usually formed with special fiber optic probes that funnel light down to an aperture that is smaller than the optical wavelength. By positioning the aperture close to a sample, the emerging radiation is forced to interact with the sample before diffracting out. Therefore, the spatial resolution in NSOM is only limited by the size of the aperture and its proximity to the sample, and not the wavelength of the light as in conventional optical microscopy.Recently, we have been using the single molecule detection limits combined with the unique nature of the electric fields present near the NSOM tip aperture to probe molecular level structure in model lipid membranes.

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