X-TREAM protocol for in vitro microbeam radiation therapy at the Australian Synchrotron

2021 ◽  
Vol 129 (24) ◽  
pp. 244902
Author(s):  
Jeremy A. Davis ◽  
Elette Engels ◽  
Marco Petasecca ◽  
Jason Paino ◽  
Moeava Tehei ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Microbeam Radiation Therapy

Combination Therapy of Cisplatin and Other Agents for Osteosarcoma: A Review

2020 ◽  
Vol 16 ◽  
Author(s):  
Mohamad Zahid Kasiram ◽  
Hermizi Hapidin ◽  
Hasmah Abdullah ◽  
Azlina Ahmad ◽  
Sarina Sulong
Keyword(s):  
Radiation Therapy ◽  
Survival Rate ◽  
Chemotherapeutic Agents ◽  
New Combination ◽  
Rapid Progression ◽  
Combination Regimen ◽  
Chemotherapeutic Drugs ◽  
Primary Bone Tumor ◽  
Phytochemical Compounds

Background: Osteosarcoma is the most common type of primary bone tumor in children and adolescents, which is associated with rapid progression and poor prognosis. Multimodal therapy is the most common approach utilized for osteosarcoma management, such as the application of chemotherapy in combination with surgery or radiation therapy. Cisplatin is one of the predominantly used chemotherapeutic agents for osteosarcoma. Optimally, it is employed in combination with other chemotherapeutic drugs along with surgery or radiation therapy. Despite the availability of numerous treatment approaches, patient survival rate has not definitively improved over the past three decades. Methods: We summarized all findings regarding the combination of cisplatin with other chemotherapeutic agents as well as with phytochemical compounds. Results: A combination of cisplatin with phytochemical compound synergistically enhances the killing effect of cisplatin on osteosarcoma cells with fewer side effects compared to combination with other chemotherapeutic agents. Conclusion: Conclusively, a combination of cisplatin with selected chemotherapeutic drugs, has been shown to be effective. However, the unchanged survival rate urges for the search of a new combination regimen. As a collaborative effort to substantiate the therapeutic efficacy, the combination with phytochemical compounds shows a promising response both in vitro as well as in the preclinical study.

PO-1606: Measurement of dose distribution of cardiosynchronous brain motion in microbeam radiation therapy

2020 ◽  
Vol 152 ◽  
pp. S874
Author(s):  
M. Petasecca ◽  
M. Duncan ◽  
M. Donzelli ◽  
P. Pellicioli ◽  
E. Brauer-Krisch ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Dose Distribution ◽  
Microbeam Radiation Therapy ◽  
Brain Motion

scholarly journals Chalcone JAI-51 improves efficacy of synchrotron microbeam radiation therapy of brain tumors

2012 ◽  
Vol 19 (4) ◽  
pp. 478-482 ◽  
Author(s):  
Audrey Bouchet ◽  
Ahcene Boumendjel ◽  
Enam Khalil ◽  
Raphael Serduc ◽  
Elke Bräuer ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Brain Tumors ◽  
Microbeam Radiation Therapy

scholarly journals Delta-6-desaturase inhibitor enhances radiation therapy in glioblastoma in vitro and in vivo

2018 ◽  
Vol Volume 10 ◽  
pp. 6779-6790 ◽  
Author(s):  
Jie Wang ◽  
Huaxin Liang ◽  
Meiyan Sun ◽  
Lei Zhang ◽  
Huijing Xu ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Delta 6 Desaturase

New Aspects of Radiotherapy in Rheumatoid Arthritis Biomarker: Radio Sensitivity Response to Acute Ionizing Radiation Induces Cell Characteristic Reprogramming and Enhanced Cytokine Release of In Vitro Activated Macrophage Cell Line (RAW 264.7)

2021 ◽  
Author(s):  
Zahra Bagheri-Hosseinabadi ◽  
Jaber Zafari ◽  
Fatemeh Javani Jouni ◽  
Hossein Abbasinia ◽  
Mitra Abbasifard
Keyword(s):  
Rheumatoid Arthritis ◽  
Radiation Therapy ◽  
Ionizing Radiation ◽  
Gamma Radiation ◽  
Inflammatory Disease ◽  
Raw 264.7 ◽  
Macrophage Cell Line ◽  
Macrophage Cell ◽  
Apoptotic Genes

Abstract The response of biological systems to various types of radiations have many ambiguous dimensions. Among ionizing radiations, in vitro external gamma radiation therapy has mostly studied as model to declare the biological system challenges with radiation effects. Cell/organism exposure to gamma radiation, caused cascade of ionization events such as severe irreversible biological damages. However, the biological responses and oxidative stress related mechanisms under acute radiation conditions poorly understood in inflammatory systems. Following study tried to give a model about ionizing radiation effect on the macrophage that had a key role in inflammation mechanisms; to evaluate the impact of radiotherapy approach for inflammatory disease as rheumatoid arthritis. To this aim, Macrophage cell line (RAW 264.7) culture, exposed to different doses of gamma radiation (0,4, 6, 8, 10 Gy). Cell viability, apoptosis, cell cycle, migration; NO and PGE2 production; expression of pro-inflammatory and apoptotic genes and cytokine secretion of macrophages was also evaluated.The results showed that gamma treatment, at 4 Gy radiation, have slight effect on macrophage characteristics and cytokine secretion pattern. Versus, higher doses (8 and 10 Gy) increased DNA damage, expression of apoptotic genes and secretion of NO and PGE2 cytokines. 6 Gy radiation, the maximum radiation dose, show moderate nondestructive effects and inflammation process modulation. In this study, doses higher than 6 Gy of Gamma radiation caused cell mortality. It seems that 6 Gy Gamma radiation modulate the inflammatory cascade caused by macrophage cell, as a central core of autoimmune inflammatory disease in acute dose radiation therapy.

Synergistic anticancer activity of sorafenib, paclitaxel, and radiation therapy on anaplastic thyroid cancer in vitro and in vivo

Head & Neck ◽  
2020 ◽  
Vol 42 (12) ◽  
pp. 3678-3684
Author(s):  
Soo Young Kim ◽  
Seok‐Mo Kim ◽  
Hojin Chang ◽  
Hang‐Seok Chang ◽  
Cheong Soo Park ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Thyroid Cancer ◽  
Anticancer Activity ◽  
Anaplastic Thyroid Cancer

Film dosimetry studies for patient specific quality assurance in microbeam radiation therapy

2019 ◽  
Vol 65 ◽  
pp. 227-237
Author(s):  
Alexandre Ocadiz ◽  
Jayde Livingstone ◽  
Mattia Donzelli ◽  
Stefan Bartzsch ◽  
Christian Nemoz ◽  
...  
Keyword(s):  
Quality Assurance ◽  
Radiation Therapy ◽  
Patient Specific ◽  
Film Dosimetry ◽  
Microbeam Radiation Therapy
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