Global vs local control of cardiac alternans in a 1D numerical model of human ventricular tissue

2020 ◽  
Vol 30 (8) ◽  
pp. 083123
Author(s):  
Sanket Thakare ◽  
Joseph Mathew ◽  
Sharon Zlochiver ◽  
Xiaopeng Zhao ◽  
Elena G. Tolkacheva
Keyword(s):  
Numerical Model ◽  
Local Control ◽  
Ventricular Tissue ◽  
Cardiac Alternans

Comparing global and local control of cardiac alternans

Scilight ◽  
2020 ◽  
Vol 2020 (33) ◽  
pp. 331101
Author(s):  
Chris Patrick
Keyword(s):  
Local Control ◽  
Cardiac Alternans ◽  
Global And Local

Confocal imaging of calcium in intact ventricular muscle provides a new view of excitation-contraction coupling

1996 ◽  
Vol 54 ◽  
pp. 738-739
Author(s):  
W.G. Wier
Keyword(s):  
Local Control ◽  
Cardiac Tissue ◽  
Cell Function ◽  
Isolated Heart ◽  
Cardiac Cells ◽  
Confocal Imaging ◽  
Ion Concentration ◽  
Heart Cell ◽  
Free Calcium ◽  
Heart Cells

A fundamentally new understanding of cardiac excitation-contraction (E-C) coupling is being developed from recent experimental work using confocal microscopy of single isolated heart cells. In particular, the transient change in intracellular free calcium ion concentration ([Ca2+]i transient) that activates muscle contraction is now viewed as resulting from the spatial and temporal summation of small (∼ 8 μm3), subcellular, stereotyped ‘local [Ca2+]i-transients' or, as they have been called, ‘calcium sparks'. This new understanding may be called ‘local control of E-C coupling'. The relevance to normal heart cell function of ‘local control, theory and the recent confocal data on spontaneous Ca2+ ‘sparks', and on electrically evoked local [Ca2+]i-transients has been unknown however, because the previous studies were all conducted on slack, internally perfused, single, enzymatically dissociated cardiac cells, at room temperature, usually with Cs+ replacing K+, and often in the presence of Ca2-channel blockers. The present work was undertaken to establish whether or not the concepts derived from these studies are in fact relevant to normal cardiac tissue under physiological conditions, by attempting to record local [Ca2+]i-transients, sparks (and Ca2+ waves) in intact, multi-cellular cardiac tissue.

1461: Local Control and Long Term Disease Free Survival Following Radical Prostatectomy for D1 Prostate Cancer In The PSA ERA

2004 ◽  
Vol 171 (4S) ◽  
pp. 385-385 ◽  
Author(s):  
Carl K. Gjertson ◽  
Kevin P. Asher ◽  
Joshua D. Sclar ◽  
Aaron E. Katz ◽  
Erik T. Goluboff ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radical Prostatectomy ◽  
Local Control ◽  
Disease Free Survival ◽  
Free Survival ◽  
Disease Free

NUMERICAL MODEL TO SIMULATE THE EROSION ON THE SLOPE DUE TO OVERTOPPING

2010 ◽  
Vol 13 (3) ◽  
pp. 78-87
Author(s):  
Hoai Cong Huynh
Keyword(s):  
Numerical Model ◽  
Flow Model ◽  
Bed Load ◽  
Experiment Data ◽  
Step Method ◽  
Morphological Model ◽  
Load Transport ◽  
Bed Load Transport ◽  
The Finite Difference Method ◽  
Good Agreement

The numerical model is developed consisting of a 1D flow model and the morphological model to simulate the erosion due to the water overtopping. The step method is applied to solve the water surface on the slope and the finite difference method of the modified Lax Scheme is applied for bed change equation. The Meyer-Peter and Muller formulae is used to determine the bed load transport rate. The model is calibrated and verified based on the data in experiment. It is found that the computed results and experiment data are good agreement.

A numerical model to verify the communication between Gari and Peccia springs (Cassino, Central Italy)

2015 ◽  
Vol 35 ◽  
pp. 268-271
Author(s):  
Michele Saroli ◽  
Michele Lancia ◽  
Marco Petitta ◽  
Gabriele Scarascia Mugnozza
Keyword(s):  
Numerical Model ◽  
Central Italy
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