Comparing global and local control of cardiac alternans

Scilight ◽  
2020 ◽  
Vol 2020 (33) ◽  
pp. 331101
Author(s):  
Chris Patrick
Keyword(s):  
Local Control ◽  
Cardiac Alternans ◽  
Global And Local

Pseudoedge: A Hierarchical Skeletal Modeler for the Design of Structural Components

1991 ◽  
Author(s):  
David L. Bonner ◽  
Mark J. Jakiela ◽  
Masaki Watanabe
Keyword(s):  
Parameter Space ◽  
Local Control ◽  
Tangent Plane ◽  
Design Model ◽  
Shape Features ◽  
Structural Components ◽  
General Shape ◽  
Isolated Singularities ◽  
Traditional Design ◽  
Global And Local

Abstract A new design model for the creation of mechanical components has been developed. In this model, the shape is expressed by its areas of prominence or maximum curvature, for which we use the term pseudoedges. In terms of traditional design, these represent both fillet, chamfer and intersection lines, and more general shape features. The pseudoedges of the model combine with a skeletal shape that is used as a starting form, thereby creating a hierarchy of geometric dependencies that affords both global and local control. The surface is represented by a quilt of parametric Bezier patches, with tangent plane continuity everywhere and only certain isolated singularities. Considerable degrees of deformation are possible, with predictable control and at small computational expense; there is no need for computation of intersections or parameter space trimming of patches.

Global vs local control of cardiac alternans in a 1D numerical model of human ventricular tissue

2020 ◽  
Vol 30 (8) ◽  
pp. 083123
Author(s):  
Sanket Thakare ◽  
Joseph Mathew ◽  
Sharon Zlochiver ◽  
Xiaopeng Zhao ◽  
Elena G. Tolkacheva
Keyword(s):  
Numerical Model ◽  
Local Control ◽  
Ventricular Tissue ◽  
Cardiac Alternans

Global and local control of microtubule destabilization promoted by a catastrophe kinesin MCAK/XKCM1

2006 ◽  
Vol 27 (2) ◽  
pp. 107-114 ◽  
Author(s):  
Kazuhisa Kinoshita ◽  
Tim L. Noetzel ◽  
Isabelle Arnal ◽  
David N. Drechsel ◽  
Anthony A. Hyman
Keyword(s):  
Local Control ◽  
Global And Local

Global and Local Control of Spatiotemporal Chaos in Coupled Map Lattices

1998 ◽  
Vol 81 (7) ◽  
pp. 1401-1404 ◽  
Author(s):  
Nita Parekh ◽  
S. Parthasarathy ◽  
Somdatta Sinha
Keyword(s):  
Local Control ◽  
Spatiotemporal Chaos ◽  
Coupled Map Lattices ◽  
Global And Local

scholarly journals SUMO-mediated global and local control of recombination

Cell Cycle ◽  
2016 ◽  
Vol 15 (2) ◽  
pp. 160-161 ◽  
Author(s):  
Madhusoodanan Urulangodi ◽  
Barnabas Szakal ◽  
Dana Branzei
Keyword(s):  
Local Control ◽  
Global And Local

Sunspot Groups as Tracers of Sub-Surface Processes

2000 ◽  
Vol 179 ◽  
pp. 155-160
Author(s):  
M. H. Gokhale
Keyword(s):  
Magnetic Flux ◽  
Indian Institute ◽  
Surface Processes ◽  
The Sun ◽  
Global And Local ◽  
Sunspot Groups

AbstractData on sunspot groups have been quite useful for obtaining clues to several processes on global and local scales within the sun which lead to emergence of toroidal magnetic flux above the sun’s surface. I present here a report on such studies carried out at Indian Institute of Astrophysics during the last decade or so.

Confocal imaging of calcium in intact ventricular muscle provides a new view of excitation-contraction coupling

1996 ◽  
Vol 54 ◽  
pp. 738-739
Author(s):  
W.G. Wier
Keyword(s):  
Local Control ◽  
Cardiac Tissue ◽  
Cell Function ◽  
Isolated Heart ◽  
Cardiac Cells ◽  
Confocal Imaging ◽  
Ion Concentration ◽  
Heart Cell ◽  
Free Calcium ◽  
Heart Cells

A fundamentally new understanding of cardiac excitation-contraction (E-C) coupling is being developed from recent experimental work using confocal microscopy of single isolated heart cells. In particular, the transient change in intracellular free calcium ion concentration ([Ca2+]i transient) that activates muscle contraction is now viewed as resulting from the spatial and temporal summation of small (∼ 8 μm3), subcellular, stereotyped ‘local [Ca2+]i-transients' or, as they have been called, ‘calcium sparks'. This new understanding may be called ‘local control of E-C coupling'. The relevance to normal heart cell function of ‘local control, theory and the recent confocal data on spontaneous Ca2+ ‘sparks', and on electrically evoked local [Ca2+]i-transients has been unknown however, because the previous studies were all conducted on slack, internally perfused, single, enzymatically dissociated cardiac cells, at room temperature, usually with Cs+ replacing K+, and often in the presence of Ca2-channel blockers. The present work was undertaken to establish whether or not the concepts derived from these studies are in fact relevant to normal cardiac tissue under physiological conditions, by attempting to record local [Ca2+]i-transients, sparks (and Ca2+ waves) in intact, multi-cellular cardiac tissue.

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