scholarly journals Non-invasive optical focusing inside strongly scattering media with linear fluorescence

2020 ◽  
Vol 116 (24) ◽  
pp. 241104
Author(s):  
Dayan Li ◽  
Sujit Kumar Sahoo ◽  
Huy Quoc Lam ◽  
Dong Wang ◽  
Cuong Dang
2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Zhipeng Yu ◽  
Jiangtao Huangfu ◽  
Fangyuan Zhao ◽  
Meiyun Xia ◽  
Xi Wu ◽  
...  

2017 ◽  
Vol 111 (22) ◽  
pp. 221109 ◽  
Author(s):  
Ashton S. Hemphill ◽  
Yuecheng Shen ◽  
Yan Liu ◽  
Lihong V. Wang

Photonics ◽  
2019 ◽  
Vol 6 (3) ◽  
pp. 80 ◽  
Author(s):  
Vyacheslav Kalchenko ◽  
Anton Sdobnov ◽  
Igor Meglinski ◽  
Yuri Kuznetsov ◽  
Guillaume Molodij ◽  
...  

Laser speckle imaging (LSI) is a well-known and useful approach for the non-invasive visualization of flows and microcirculation localized in turbid scattering media, including biological tissues (such as brain vasculature, skin capillaries etc.). Despite an extensive use of LSI for brain imaging, the LSI technique has several critical limitations. One of them is associated with inability to resolve a functionality of vessels. This limitation also leads to the systematic error in the quantitative interpretation of values of speckle contrast obtained for different vessel types, such as sagittal sinus, arteries, and veins. Here, utilizing a combined use of LSI and fluorescent intravital microscopy (FIM), we present a simple and robust method to overcome the limitations mentioned above for the LSI approach. The proposed technique provides more relevant, abundant, and valuable information regarding perfusion rate ration between different types of vessels that makes this method highly useful for in vivo brain surgical operations.


Optica ◽  
2015 ◽  
Vol 2 (10) ◽  
pp. 869 ◽  
Author(s):  
Cheng Ma ◽  
Fengbo Zhou ◽  
Yan Liu ◽  
Lihong V. Wang

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