Design and preparation of bionic hemostatic dressing based on chitosan

2020 ◽  
Author(s):  
Fenmiao Zhong ◽  
Ningyue Liang
Keyword(s):  
Hemostatic Dressing

Use of a Chitosan-Based Hemostatic Dressing in Dacryocystorhinostomy

2009 ◽  
Vol 25 (5) ◽  
pp. 350-353 ◽  
Author(s):  
Roger A. Dailey ◽  
Mauricio R. Chavez ◽  
Dongseok Choi
Keyword(s):  
Hemostatic Dressing

Chitosan based hemostatic dressing is associated with decreased blood loss in a swine uncontrolled hemorrhage model

2012 ◽  
Vol 215 (3) ◽  
pp. S54-S55
Author(s):  
Nicholas R. Kunio ◽  
Gordon M. Riha ◽  
Katherine M. Watson ◽  
Igor V. Kremenevskiy ◽  
Jerome A. Differding ◽  
...  
Keyword(s):  
Blood Loss ◽  
Hemostatic Dressing ◽  
Uncontrolled Hemorrhage

scholarly journals Chitosan Acetate Bandage as a Topical Antimicrobial Dressing for Infected Burns

2008 ◽  
Vol 53 (2) ◽  
pp. 393-400 ◽  
Author(s):  
Tianhong Dai ◽  
George P. Tegos ◽  
Marina Burkatovskaya ◽  
Ana P. Castano ◽  
Michael R. Hamblin
Keyword(s):  
Survival Rate ◽  
Chemical Structure ◽  
Bacterial Species ◽  
Survival Rates ◽  
Bioluminescent Bacteria ◽  
Systemic Sepsis ◽  
Hemostatic Dressing ◽  
Topical Antimicrobial ◽  
Number Of Bacteria ◽  
Growth Of Bacteria

ABSTRACT An engineered chitosan acetate bandage preparation (HemCon) is used as a hemostatic dressing, and its chemical structure suggests that it should also be antimicrobial. We previously showed that when a chitosan acetate bandage was applied to full-thickness excisional wounds in mice that had been infected with pathogenic bioluminescent bacteria (Pseudomonas aeruginosa, Proteus mirabilis, and Staphylococcus aureus), it was able to rapidly kill the bacteria and save the mice from developing fatal infections. Wound healing was also stimulated. In the present study, we asked whether a chitosan acetate bandage could act as a topical antimicrobial dressing when it was applied to third-degree burns in mice contaminated with two of these bacterial species (P. aeruginosa and P. mirabilis). Preliminary experiments established the length of burn time and the number of bacteria needed to produce fatal infections in untreated mice and established that the chitosan acetate bandage could adhere to the infected burn for up to 21 days. In the case of P. aeruginosa infections, the survival rate of mice treated with the chitosan acetate bandage was 73.3% (whereas the survival rate of mice treated with a nanocrystalline silver dressing was 27.3% [P = 0.0055] and that of untreated mice was 13.3% [P < 0.0002]). For P. mirabilis infections, the comparable survival rates were 66.7%, 62.5%, and 23.1% respectively. Quantitative bioluminescent signals showed that the chitosan acetate bandage effectively controlled the growth of bacteria in the burn and prevented the development of systemic sepsis, as shown by blood culture. These data suggest that chitosan acetate bandage is efficacious in preventing fatal burn infections.

scholarly journals Comparison of experimental wound healing in quail using two types of commercial hemostatic dressings

2021 ◽  
Vol 15 (2) ◽  
pp. 146-152
Author(s):  
Tainá M. P. Chiquito ◽  
Margarete K. Falbo ◽  
Rafael V. Soares ◽  
Roberta A. Marcondes ◽  
Jayme A. Peres ◽  
...  
Keyword(s):  
Wound Healing ◽  
Leukocyte Count ◽  
Visual Assessment ◽  
Total Leukocyte Count ◽  
Expected Time ◽  
Post Procedure ◽  
Superficial Skin ◽  
Hemostatic Dressing ◽  
Corticosterone Metabolites ◽  
Fecal Corticosterone Metabolites

The use of powdered hemostatic products and propolis-based preparations has become increasingly common to control bleeding and aid healing. This study evaluated two hemostatic dressings, one based on propolis (Alveolex®) and the other on ferric subsulfate powder (Quick Blood Stopper®), on experimental wound in quails. The experiment was conducted with 36 quails assigned to three groups: control, propolis-based hemostatic dressing and ferric subsulfate-based hemostatic dressing, on two types of wounds, superficial (skin and subcutaneous) and deep (skin, subcutaneous and muscle). Pre- (day-7) and post-procedure (days 2 and 10) examinations showed a tendency to reduce hematocrit values on day 2 and a tendency to increase fibrinogen levels and total leukocyte count on the same day. Visual assessment of wound healing indicated that birds using Quick Blood Stopper® showed signs of poor healing, while the group treated with Alveolex® had uncomplicated healing within the expected time. The groups treated with hemostatic based on ferric subsulfate showed a tendency to increase the values of fecal corticosterone metabolites on day 10, suggesting an increased level of stress in these animals. During the surgical procedure, both hemostatic products controlled bleeding, but Alveolex®was more efficient and easy to handle.

scholarly journals Biological Effects of Chitosan-Based Dressing on Hemostasis Mechanism

Polymers ◽  
2019 ◽  
Vol 11 (11) ◽  
pp. 1906
Author(s):  
Wang ◽  
Liu ◽  
Cherng ◽  
Lin ◽  
Chang ◽  
...  
Keyword(s):  
Wound Care ◽  
Biological Effects ◽  
Underlying Mechanism ◽  
Hospital Emergency ◽  
Surgical Wounds ◽  
Severe Hemorrhage ◽  
Hemostatic Dressing ◽  
Gauze Dressing ◽  
Chitosan Fiber ◽  
Uncontrolled Hemorrhage

: There have been numerous recent advances in wound care management. Nevertheless, the assessment of hemostatic dressing is essential to enable surgeons and other physicians and healthcare professionals to make the correct decisions regarding the disposition of severe hemorrhage. Here, we investigated the relative efficacies of chitosan-based and conventional gauze dressings in a rat model of femoral artery hemorrhage and in patients with surgical wounds. Dressing effectiveness was evaluated based on hemostatic profiles, biocompatibility, antimicrobial activity, and blood factor responses in coagulation. Relative to standard gauze dressing, the chitosan fiber (CF) dressing treatment significantly shortened the time to hemostasis in injured rats. Moreover, the CF dressing significantly prolonged partial thromboplastin time, enhanced blood absorption, and reduced antithrombin production without altering the prothrombin ratio. Unlike regular gauze bandages, the CF dressing demonstrated remarkable antibacterial activity. The results of this study indicate the effectiveness of chitosan as a hemostatic dressing and elucidate its underlying mechanism. It is possible that chitosan surgical dressings could serve as first-line intervention in hospital emergency care for uncontrolled hemorrhage.

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