Special Issue: Physical Review Centenary—From Basic Research to High Technology

Physics Today ◽  
1993 ◽  
Vol 46 (10) ◽  
pp. 22-25 ◽  
Author(s):  
Robert K. Adair ◽  
Ernest M. Henley
Keyword(s):  
Basic Research ◽  
High Technology ◽  
Physical Review ◽  
Special Issue

Protein Solvent Interaction: Transition of Protein-solvent Interaction Concept from Basic Research into Solvent Manipulation of Chromatography

2018 ◽  
Vol 20 (1) ◽  
pp. 34-39 ◽  
Author(s):  
Tsutomu Arakawa ◽  
Yoshiko Kita
Keyword(s):  
Column Chromatography ◽  
Rapid Development ◽  
Academic Research ◽  
Basic Research ◽  
Protein Stabilization ◽  
Special Issue ◽  
Solvent Interaction ◽  
Protein Formulations ◽  
Solvent Additive ◽  
Downstream Processes

Previously, we have reviewed in this journal (Arakawa, T., Kita, Y., Curr. Protein Pept. Sci., 15, 608-620, 2014) the interaction of arginine with proteins and various applications of this solvent additive in the area of protein formulations and downstream processes. In this special issue, we expand the concept of protein-solvent interaction into the analysis of the effects of solvent additives on various column chromatography, including mixed-mode chromatography. Earlier in our research, we have studied the interactions of such a variety of solvent additives as sugars, salts, amino acids, polymers and organic solvents with a variety of proteins, which resulted in mechanistic understanding on their protein stabilization and precipitation effects, the latter known as Hofmeister series. While such a study was then a pure academic research, rapid development of genetic engineering technologies and resultant biotechnologies made it a valuable knowledge in fully utilizing solvent additives in manipulation of protein solution, including column chromatography.

scholarly journals Mesenchymal Stem/Stromal Cells in Immunity and Disease: A Better Understanding for an Improved Use

2020 ◽  
Vol 9 (5) ◽  
pp. 1516 ◽  
Author(s):  
Makram Merimi ◽  
Laurence Lagneaux ◽  
Douâa Moussa Agha ◽  
Philippe Lewalle ◽  
Nathalie Meuleman ◽  
...  
Keyword(s):  
Regenerative Medicine ◽  
Stromal Cells ◽  
State Of The Art ◽  
Basic Research ◽  
Research Articles ◽  
Great Promise ◽  
Special Issue ◽  
Tissue Microenvironment ◽  
Therapeutic Value ◽  
Immunomodulatory Properties

In this Special Issue, directed and supervised by Dr. Mehdi Najar, a collection of basic research articles and reviews, on the state of the art of Mesenchymal Stem/Stromal Cells (MSCs) immune biology, is presented. Among the major goals of this Special Issue is the presentation of an update about the immunomodulatory properties of MSCs and their capacity to respond to tissue microenvironment changes. MSCs hold great promise in the field of immunotherapy and regenerative medicine. Accordingly, a better understanding of MSC immune biology will improve their therapeutic value and use.

scholarly journals Microbes in Our Food, an Ongoing Problem with New Solutions

Antibiotics ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 584
Author(s):  
Birgit M. Prüβ
Keyword(s):  
Food Processing ◽  
Microbial Contamination ◽  
Bacterial Resistance ◽  
Disease Outbreaks ◽  
Basic Research ◽  
The United States ◽  
Bacterial Biofilms ◽  
Special Issue ◽  
Food Borne ◽  
Processing Facility

Despite an increasing number of techniques that are designed to mitigate microbial contamination of food and the resulting food borne disease outbreaks, the United States and many other countries across the world continue to experience impressive numbers of such outbreaks. Microbial contamination can occur during activities that take place in the pre-harvest environment or in the processing facility post-harvest. Current treatments of food that are aimed at reducing bacterial numbers may be only partially effective because of the development of bacterial resistance, the formation of bacterial biofilms, and inactivation of the treatment compound by the food products themselves. This Special Issue will include basic research approaches that are aimed at enhancing our understanding of how contamination occurs throughout the food processing chain, as well as more immediate and applied approaches to the development and use of novel anti-microbials to combat microbes in food. Novel techniques that aim to evaluate the efficacy of novel anti-microbials are included. Overall, we present a broad spectrum of novel approaches to reduce microbial contamination on food at all stages of production.

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