The role of turbulent fluid dynamics in water/oil emulsion formation

1991 ◽  
Vol 3 (5) ◽  
pp. 1456-1456
Author(s):  
R. Oliver ◽  
J. G. B. Smith
Keyword(s):  
Fluid Dynamics ◽  
Oil Emulsion ◽  
Turbulent Fluid

scholarly journals Glaucoma and the Role of Cerebrospinal Fluid Dynamics

2015 ◽  
Vol 56 (11) ◽  
pp. 6630 ◽  
Author(s):  
Peter Wostyn ◽  
Veva De Groot ◽  
Debby Van Dam ◽  
Kurt Audenaert ◽  
Hanspeter Esriel Killer ◽  
...  
Keyword(s):  
Fluid Dynamics ◽  
Cerebrospinal Fluid ◽  
Cerebrospinal Fluid Dynamics

scholarly journals Induction of Neutralizing Antibodies against Human Immunodeficiency Virus Type 1 Primary Isolates by Gag-Env Pseudovirion Immunization

2005 ◽  
Vol 79 (23) ◽  
pp. 14804-14814 ◽  
Author(s):  
Jason Hammonds ◽  
Xuemin Chen ◽  
Timothy Fouts ◽  
Anthony DeVico ◽  
David Montefiori ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Neutralizing Antibodies ◽  
Neutralizing Antibody ◽  
Antibody Responses ◽  
Oil Emulsion ◽  
Cpg Oligodeoxynucleotides ◽  
Immunodeficiency Virus ◽  
Monomeric Gp120

ABSTRACT A major challenge for the development of an effective HIV vaccine is to elicit neutralizing antibodies against a broad array of primary isolates. Monomeric gp120-based vaccine approaches have not been successful in inducing this type of response, prompting a number of approaches designed to recreate the native glycoprotein complex that exists on the viral membrane. Gag-Env pseudovirions are noninfectious viruslike particles that recreate the native envelope glycoprotein structure and have the potential to generate neutralizing antibody responses against primary isolates. In this study, an inducible cell line was created in order to generate Gag-Env pseudovirions for examination of neutralizing antibody responses in guinea pigs. Unadjuvanted pseudovirions generated relatively weak anti-gp120 responses, while the use of a block copolymer water-in-oil emulsion or aluminum hydroxide combined with CpG oligodeoxynucleotides resulted in high levels of antibodies that bind to gp120. Sera from immunized animals neutralized a panel of human immunodeficiency virus (HIV) type 1 primary isolate viruses at titers that were significantly higher than that of the corresponding monomeric gp120 protein. Interpretation of these results was complicated by the occurrence of neutralizing antibodies directed against cellular (non-envelope protein) components of the pseudovirion. However, a major component of the pseudovirion-elicited antibody response was directed specifically against the HIV envelope. These results provide support for the role of pseudovirion-based vaccines in generating neutralizing antibodies against primary isolates of HIV and highlight the potential confounding role of antibodies directed at non-envelope cell surface components.

Modelling and Simulation in Biomedical Research

2011 ◽  
pp. 794-806
Author(s):  
Dolores A. Steinman ◽  
David A. Steinman
Keyword(s):  
Fluid Dynamics ◽  
Visual Representation ◽  
Circulatory System ◽  
Disease Development ◽  
Step Process ◽  
Non Invasive ◽  
System Disease ◽  
Computational Fluid Dynamics Cfd ◽  
Circulatory System Disease

In the following chapter, the authors will discuss the development of medical imaging and, through specific case studies, its application in elucidating the role of fluid mechanical forces in cardiovascular disease development and therapy (namely the connection between flow patterns and circulatory system disease - atherosclerosis and aneurysms) by means of computational fluid dynamics (CFD). The research carried in the Biomedical Simulation Laboratory can be described as a multi-step process through which, from the reality of the human body through the generation of a mathematical model that is then translated into a visual representation, a refined visual representation easily understandable and used in the clinic is generated. Thus, the authors’ daily research generates virtual representations of blood flow that can serve two purposes: a) that of a model for a phenomenon or disease or b) that of a model for an experiment (non-invasive way of determining the best treatment option).

scholarly journals Numerical Analysis of Blood Flow Through Discrete Stenosis: Role of Eccentricity and Spacing Ratio

2017 ◽  
Author(s):  
Siyeong Ju ◽  
Linxia Gu
Keyword(s):  
Fluid Dynamics ◽  
Blood Flow ◽  
Recirculation Zone ◽  
Cfd Simulation ◽  
Flow Region ◽  
Flow Recirculation ◽  
Spacing Ratio ◽  
Computational Fluid Dynamics Cfd ◽  
Flow Interference

Stenosis or narrowing of arteries induces a turbulent flow region downstream. Multiple stenosis may lead to flow interference and further disturb the blood flow. This has important clinical implications [1], such as disturbed blood flow and flow recirculation which were correlated with the development of atherosclerosis by upregulating the endothelial cells genes and proteins that cause atherogenesis [2]. Numerical simulation of concentric stenoses by Lee et al [3] have shown that the recirculation zone following the first concentric stenosis affected the flow field at the downstream of the second one, which was dependent on the spacing ratio and degree of stenosis. However, the majority of stenosis is eccentric [2] and the detailed fluid dynamics of multiple stenoses with eccentric constrictions is lacking. The aim of this study is to investigate the interactions between double stenoses with eccentricity using computational fluid dynamics (CFD) simulation. The role of spacing ratio on the recirculation zone and turbulence intensity (TI) were characterized and also compared to concentric cases.

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