scholarly journals Diffusion coefficient measurement system based on laser beam deflection on liquid: Image and data processing

2019 ◽  
Author(s):  
L. Soedarmawan ◽  
M. Aman ◽  
A. Hifzhi ◽  
S. Pambudi ◽  
A. Sudarmaji ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Laser Beam ◽  
Data Processing ◽  
Measurement System ◽  
Beam Deflection ◽  
Coefficient Measurement

Portable device based on beam deflection for refractive index mapping and diffusion coefficient measurement

2019 ◽  
Vol 58 (01) ◽  
pp. 1
Author(s):  
Vismay Trivedi ◽  
Mugdha Joglekar ◽  
Swapnil Mahajan ◽  
Vani Chhaniwal ◽  
Bahram Javidi ◽  
...  
Keyword(s):  
Refractive Index ◽  
Diffusion Coefficient ◽  
Portable Device ◽  
Beam Deflection ◽  
Index Mapping ◽  
Coefficient Measurement ◽  
And Diffusion

A two-axis in-plane motion measurement system based on optical beam deflection

2013 ◽  
Vol 84 (10) ◽  
pp. 105001 ◽  
Author(s):  
R. Sriramshankar ◽  
R. Sri Muthu Mrinalini ◽  
G. R. Jayanth
Keyword(s):  
Measurement System ◽  
Plane Motion ◽  
Optical Beam ◽  
Beam Deflection ◽  
Motion Measurement

scholarly journals In Vivo Experimental and Analytical Studies for Bevacizumab Diffusion Coefficient Measurement in the Rabbit Vitreous Humor

2020 ◽  
Author(s):  
Shuqi Zhang ◽  
Anita Penkova ◽  
Mark Humayun ◽  
Juan Carlos Martinez-Camarillo ◽  
Abegail C. Tadle ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Effective Diffusion ◽  
Drug Distribution ◽  
Vitreous Humor ◽  
Contour Method ◽  
Experimental Result ◽  
Coefficient Measurement ◽  
A New Technique ◽  
Best Fit

Abstract In order to measure the effective diffusion coefficient of Bevacizumab (Avastin, Genentech) in the vitreous humor, a new technique is developed based on the 'contour method' and in vivo OCT measurements. After injection of Bevacizumab-fluorescein conjugated compound solution into the rabbit eye, the contours of drug concentration distribution at the subsurface of injection were tracked over time. The 2D contours were extrapolated to 3D contours using reasonable assumptions and a numerically integrated analytical model was developed for the theoretical contours for the irregularly shaped drug distribution in the experimental result. By floating the diffusion coefficient, different theoretical contours were constructed and the least-squares best fit to the experimental contours was performed at each time point to get the best fit solution. The approach generated consistent diffusion coefficient values based on the experiments on four rabbit eyes over a period of 3 hours each, which gave , D=1.2±0.6×(?10?^(-6) ?cm?^2)/s and the corresponding theoretical contours matched well with the experimental contours. The quantitative measurement of concentration using OCT and fluorescein labeling gives a new approach for the "non-contact" in vivo drug distribution measurement within vitreous and other ocular tissues.

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