Magnetic hyperthermia in water based ferrofluids: Effects of initial susceptibility and size polydispersity on heating efficiency

2018 ◽  
Author(s):  
B. B. Lahiri ◽  
Surojit Ranoo ◽  
T. Muthukumaran ◽  
John Philip
Keyword(s):  
Magnetic Hyperthermia ◽  
Heating Efficiency ◽  
Initial Susceptibility ◽  
Water Based

Hierarchical Lichee-like Fe3O4 Assemblies and Their High Heating Efficiency in Magnetic Hyperthermia

2021 ◽  
Author(s):  
Wen-Yu Li ◽  
Wen-Tao Li ◽  
Bang-Quan Li ◽  
Li-Juan Dong ◽  
Tian-Hua Meng ◽  
...  
Keyword(s):  
Magnetic Hyperthermia ◽  
Heating Efficiency ◽  
High Heating

scholarly journals Role of zinc substitution in magnetic hyperthermia properties of magnetite nanoparticles: interplay between intrinsic properties and dipolar interactions

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yaser Hadadian ◽  
Ana Paula Ramos ◽  
Theo Z. Pavan
Keyword(s):  
Magnetic Nanoparticles ◽  
Magnetite Nanoparticles ◽  
Linear Response Theory ◽  
Magnetic Hyperthermia ◽  
Superior Performance ◽  
Dipolar Interactions ◽  
Intrinsic Properties ◽  
Specific Loss ◽  
Heating Efficiency ◽  
Specific Loss Power

AbstractOptimizing the intrinsic properties of magnetic nanoparticles for magnetic hyperthermia is of considerable concern. In addition, the heating efficiency of the nanoparticles can be substantially influenced by dipolar interactions. Since adequate control of the intrinsic properties of magnetic nanoparticles is not straightforward, experimentally studying the complex interplay between these properties and dipolar interactions affecting the specific loss power can be challenging. Substituting zinc in magnetite structure is considered as an elegant approach to tune its properties. Here, we present experimental and numerical simulation results of magnetic hyperthermia studies using a series of zinc-substituted magnetite nanoparticles (ZnxFe1-xFe2O4, x = 0.0, 0.1, 0.2, 0.3 and 0.4). All experiments were conducted in linear regime and the results were inferred based on the numerical simulations conducted in the framework of the linear response theory. The results showed that depending on the nanoparticles intrinsic properties, interparticle interactions can have different effects on the specific loss power. When dipolar interactions were strong enough to affect the heating efficiency, the parameter σ = KeffV/kBT (Keff is the effective anisotropy and V the volume of the particles) determined the type of the effect. Finally, the sample x = 0.1 showed a superior performance with a relatively high intrinsic loss power 5.4 nHm2kg−1.

scholarly journals Systemically Delivered Magnetic Hyperthermia for Prostate Cancer Treatment

Pharmaceutics ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 1020
Author(s):  
Hassan A. Albarqi ◽  
Ananiya A. Demessie ◽  
Fahad Y. Sabei ◽  
Abraham S. Moses ◽  
Mikkel N. Hansen ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Animal Studies ◽  
Water Solubility ◽  
Polymeric Nanoparticles ◽  
Magnetic Hyperthermia ◽  
Hydrophobic Core ◽  
Prostate Cancer Treatment ◽  
Novel Therapy ◽  
Heating Efficiency ◽  
Poly Ethylene

Herein, we report a novel therapy for prostate cancer based on systemically delivered magnetic hyperthermia. Conventional magnetic hyperthermia is a form of thermal therapy where magnetic nanoparticles delivered to cancer sites via intratumoral administration produce heat in the presence of an alternating magnetic field (AMF). To employ this therapy for prostate cancer tumors that are challenging to inject intratumorally, we designed novel nanoclusters with enhanced heating efficiency that reach prostate cancer tumors after systemic administration and generate desirable intratumoral temperatures upon exposure to an AMF. Our nanoclusters are based on hydrophobic iron oxide nanoparticles doped with zinc and manganese. To overcome the challenges associated with the poor water solubility of the synthesized nanoparticles, the solvent evaporation approach was employed to encapsulate and cluster them within the hydrophobic core of PEG-PCL (methoxy poly(ethylene glycol)-b-poly(ε-caprolactone))-based polymeric nanoparticles. Animal studies demonstrated that, following intravenous injection into mice bearing prostate cancer grafts, the nanoclusters efficiently accumulated in cancer tumors within several hours and increased the intratumoral temperature above 42 °C upon exposure to an AMF. Finally, the systemically delivered magnetic hyperthermia significantly inhibited prostate cancer growth and did not exhibit any signs of toxicity.

Core/shell iron/iron oxide nanoparticles: are they promising for magnetic hyperthermia?

RSC Advances ◽  
2016 ◽  
Vol 6 (45) ◽  
pp. 38697-38702 ◽  
Author(s):  
Z. Nemati ◽  
J. Alonso ◽  
H. Khurshid ◽  
M. H. Phan ◽  
H. Srikanth
Keyword(s):  
Iron Oxide ◽  
Iron Oxide Nanoparticles ◽  
Magnetic Hyperthermia ◽  
Oxide Nanoparticles ◽  
Core Shell ◽  
Heating Efficiency ◽  
Surface Disorder ◽  
Iron Iron

Core/shell iron/iron oxide nanoparticles are promising for magnetic hyperthermia provided their size is big enough (>14 nm) in order to minimize surface disorder and hollowing effects that seriously deteriorate their heating efficiency.

scholarly journals Experimental Evaluation on the Heating Efficiency of Magnetoferritin Nanoparticles in an Alternating Magnetic Field

Nanomaterials ◽  
2019 ◽  
Vol 9 (10) ◽  
pp. 1457 ◽  
Author(s):  
Huangtao Xu ◽  
Yongxin Pan
Keyword(s):  
Magnetic Field ◽  
Relaxation Time ◽  
Magnetic Hyperthermia ◽  
Alternating Magnetic Field ◽  
Core Size ◽  
Hyperthermia Treatment ◽  
Field Frequency ◽  
Glycerol Water ◽  
Heating Efficiency ◽  
Néel Relaxation

The superparamagnetic substance magnetoferritin is a potential bio-nanomaterial for tumor magnetic hyperthermia because of its active tumor-targeting outer protein shell, uniform and tunable nanosized inner mineral core, monodispersity and good biocompatibility. Here, we evaluated the heating efficiency of magnetoferritin nanoparticles in an alternating magnetic field (AMF). The effects of core-size, Fe concentration, viscosity, and field frequency and amplitude were investigated. Under 805.5 kHz and 19.5 kA/m, temperature rise (ΔT) and specific loss power (SLP) measured on magnetoferritin nanoparticles with core size of 4.8 nm at 5 mg/mL were 14.2 °C (at 6 min) and 68.6 W/g, respectively. The SLP increased with core-size, Fe concentration, AMF frequency, and amplitude. Given that: (1) the SLP was insensitive to viscosity of glycerol-water solutions and (2) both the calculated effective relaxation time and the fitted relaxation time were closer to Néel relaxation time, we propose that the heating generation mechanism of magnetoferritin nanoparticles is dominated by the Néel relaxation. This work provides new insights into the heating efficiency of magnetoferritin and potential future applications for tumor magnetic hyperthermia treatment and heat-triggered drug release.

Recent Insights into the Potential of Magnetic Metal Nanostructures as Magnetic Hyperthermia Agents

2020 ◽  
Vol 18 (12) ◽  
pp. 861-880
Author(s):  
A. R. Aarathy ◽  
M. S. Gopika ◽  
S. Savitha Pillai
Keyword(s):  
Metal Nanoparticles ◽  
Heat Generation ◽  
Magnetic Hyperthermia ◽  
Metal Nanoparticle ◽  
Treatment Modalities ◽  
Metal Nanostructures ◽  
Synthesis Methods ◽  
Promising Alternative ◽  
Heating Efficiency ◽  
Magnetic Metal

The advancements in magnetic nanoparticle mediated hyperthermia give so many optimistic and fruitful results that make it a promising and complementary approach for the existing treatment modalities of cancer. This thermotherapy is gaining wide acceptance among the medical community compared to the conventional treatment methods. The former provides a local heat generation in the malignant tumor cells and remains non-invasive to the adjacent healthy cells. The increased heating efficiency of magnetic nanoparticles and the control of local therapeutic temperature are the main challenges of hyperthermia. Superparamagnetic Iron Oxide nanoparticles have been intensively studied and dominating in magnetic hyperthermia. Recently many researchers successfully demonstrated high heating efficiency and biocompatibility of a wide variety of magnetic metal nanoparticles and proposed as the most promising alternative for traditional iron oxides, which opens up a new avenue for magnetic metal nanoparticles in magnetic hyperthermia. The review presents the recent advancements that occurred in the field of metal nanoparticle mediated magnetic hyperthermia. The theory underlying heat generation, synthesis methods, biofunctionalization, Specific Absorption Rate studies, challenges and future perspectives of magnetic metal nanoparticles are presented. This will inspire more in-depth research and advance practical applications of metal nanoparticles in magnetic hyperthermia.

A combinatorial approach to enhance the biocompatibility and heating efficiency of magnetic hyperthermia- Serum Albumin conjugated ferrimagneticmagnetite nanoparticles

MRS Advances ◽  
2016 ◽  
Vol 1 (3) ◽  
pp. 247-254 ◽  
Author(s):  
Viveka Kalidasan ◽  
Xiaoli Liu ◽  
Jun Ding ◽  
Ananya Dasgupta ◽  
Sreedharan Sajikumar
Keyword(s):  
Serum Albumin ◽  
Specific Absorption Rate ◽  
Colloidal Stability ◽  
Treatment Method ◽  
Magnetic Hyperthermia ◽  
Combinatorial Approach ◽  
Cancer Treatments ◽  
Heating Efficiency ◽  
Non Invasive ◽  
Magnetic Heating

ABSTRACTMagnetic hyperthermia is a non-invasive cancer treatment method which is used synergistically with the current cancer treatments. Improved biocompatibility and enhanced heating characteristics are the pressing challenges to be addressed in magnetic hyperthermia. Through a novel combinatorial approach, we have attempted to address both the challenges. Ferrimagneticmagnetite nanoparticles (FMNPs)of size 50 nm were synthesized by thermal decomposition method and were converted to hydrophilic phase by 3-Aminopropyltrimethoxysilane (APTMS). Serum Albumin (SA) from rat was conjugated over the APTMS-FMNPs to convert to biocompatible phase. The preliminary haemolysis experiments show that SA-FMNPs are non-haemolytic (1.2 % haemolysis). It is observed from the magnetic heating experiments that due to better colloidal stability, the Specific Absorption Rate value of the SA-FMNPs are higher (2100 W/g) than the FMNPs without SA (1400 W/g). Thus we report here that SA conjugation over FMNPs (with a high saturation magnetization of 75 emu/g) provides a novel combinatorial approach to enhance both the biocompatibility and the SAR value for magnetic hyperthermia.

scholarly journals Shape Effects of Iron Nanowires on Hyperthermia Treatment

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Wei-Syuan Lin ◽  
Hong-Ming Lin ◽  
Hsiang-Hsin Chen ◽  
Yeu-Kuang Hwu ◽  
Yuh-Jing Chiou
Keyword(s):  
Magnetic Field ◽  
Magnetic Anisotropy ◽  
Material Properties ◽  
Iron Nanoparticles ◽  
Magnetic Hyperthermia ◽  
Hyperthermia Treatment ◽  
One Dimensional ◽  
Heating Efficiency ◽  
Shape Effects ◽  
Iron Nanowires

This research discusses the influence of morphology of nanomagnetic materials (one-dimensional iron nanowires and zero-dimensional iron nanoparticles) on heating efficiency of the hyperthermia treatment. One-dimensional iron nanowires, synthesized by reducing method in external magnetic field, are explored in terms of their material properties, magnetic anisotropy, and cytotoxicity of EMT-6 cells. The magnetic anisotropy of an array of nanowires is examined in parallel and perpendicular magnetic fields by VSM. For the magnetic hyperthermia treatment tests, iron nanowires and nanoparticles with different concentrations are heated in alternating magnetic field to measure their actual heating efficiency and SLP heating properties. The shape effects of iron nanomaterials can be revealed from their heating properties. The cytotoxicity of nanowires with different concentrations is measured by its survival rate in EMT-6 with the cells cultivated for 6 and 24 hours.

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