A combinatorial approach to enhance the biocompatibility and heating efficiency of magnetic hyperthermia- Serum Albumin conjugated ferrimagneticmagnetite nanoparticles

MRS Advances ◽  
2016 ◽  
Vol 1 (3) ◽  
pp. 247-254 ◽  
Author(s):  
Viveka Kalidasan ◽  
Xiaoli Liu ◽  
Jun Ding ◽  
Ananya Dasgupta ◽  
Sreedharan Sajikumar
Keyword(s):  
Serum Albumin ◽  
Specific Absorption Rate ◽  
Colloidal Stability ◽  
Treatment Method ◽  
Magnetic Hyperthermia ◽  
Combinatorial Approach ◽  
Cancer Treatments ◽  
Heating Efficiency ◽  
Non Invasive ◽  
Magnetic Heating

ABSTRACTMagnetic hyperthermia is a non-invasive cancer treatment method which is used synergistically with the current cancer treatments. Improved biocompatibility and enhanced heating characteristics are the pressing challenges to be addressed in magnetic hyperthermia. Through a novel combinatorial approach, we have attempted to address both the challenges. Ferrimagneticmagnetite nanoparticles (FMNPs)of size 50 nm were synthesized by thermal decomposition method and were converted to hydrophilic phase by 3-Aminopropyltrimethoxysilane (APTMS). Serum Albumin (SA) from rat was conjugated over the APTMS-FMNPs to convert to biocompatible phase. The preliminary haemolysis experiments show that SA-FMNPs are non-haemolytic (1.2 % haemolysis). It is observed from the magnetic heating experiments that due to better colloidal stability, the Specific Absorption Rate value of the SA-FMNPs are higher (2100 W/g) than the FMNPs without SA (1400 W/g). Thus we report here that SA conjugation over FMNPs (with a high saturation magnetization of 75 emu/g) provides a novel combinatorial approach to enhance both the biocompatibility and the SAR value for magnetic hyperthermia.

scholarly journals Iron Oxide Nanorings and Nanotubes for Magnetic Hyperthermia: The Problem of Intraparticle Interactions

Nanomaterials ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 1380
Author(s):  
Raja Das ◽  
Javier Alonso Masa ◽  
Vijaysankar Kalappattil ◽  
Zohreh Nemati ◽  
Irati Rodrigo ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Magnetic Nanoparticles ◽  
Absorption Rate ◽  
Specific Absorption Rate ◽  
Magnetic Nanostructures ◽  
Hysteresis Loops ◽  
Magnetic Hyperthermia ◽  
Magnetic Interactions ◽  
Effective Anisotropy ◽  
Heating Efficiency

Magnetic interactions can play an important role in the heating efficiency of magnetic nanoparticles. Although most of the time interparticle magnetic interactions are a dominant source, in specific cases such as multigranular nanostructures intraparticle interactions are also relevant and their effect is significant. In this work, we have prepared two different multigranular magnetic nanostructures of iron oxide, nanorings (NRs) and nanotubes (NTs), with a similar thickness but different lengths (55 nm for NRs and 470 nm for NTs). In this way, we find that the NTs present stronger intraparticle interactions than the NRs. Magnetometry and transverse susceptibility measurements show that the NTs possess a higher effective anisotropy and saturation magnetization. Despite this, the AC hysteresis loops obtained for the NRs (0–400 Oe, 300 kHz) are more squared, therefore giving rise to a higher heating efficiency (maximum specific absorption rate, SARmax = 110 W/g for the NRs and 80 W/g for the NTs at 400 Oe and 300 kHz). These results indicate that the weaker intraparticle interactions in the case of the NRs are in favor of magnetic hyperthermia in comparison with the NTs.

Fe2O3 nanoparticles for magnetic hyperthermia applications

2015 ◽  
Vol 1779 ◽  
pp. 7-13 ◽  
Author(s):  
O M Lemine ◽  
Karim Omri ◽  
L El Mir ◽  
V Velasco ◽  
Patricia Crespo ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Magnetic Properties ◽  
Absorption Rate ◽  
Specific Absorption Rate ◽  
Magnetic Hyperthermia ◽  
Fe2o3 Nanoparticles ◽  
X Ray Diffraction ◽  
X Ray ◽  
Heating Efficiency ◽  
Hall Method

ABSTRACTSynthesis, structural, magnetic properties and heating efficiency of γ-Fe2O3 nanoparticles have been investigated. X-ray diffraction (XRD) and Mössbauer spectroscopy show that the obtained nanoparticles are mainly composed of maghemite phase (γ-Fe2O3). Williamson-Hall method shows that the crystallite is around 14nm.The specific absorption rate (SAR) under an alternating magnetic field is investigated as a function of frequency. A highest SAR value of 12W/g for frequency 523 kHz was obtained.

Stable Iron Oxide Nanoflowers with Exceptional Magnetic Heating Efficiency: Simple and Fast Polyol Synthesis

2021 ◽  
Vol 13 (38) ◽  
pp. 45870-45880
Author(s):  
Liudmyla Storozhuk ◽  
Maximilian O. Besenhard ◽  
Stefanos Mourdikoudis ◽  
Alec P. LaGrow ◽  
Martin R. Lees ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Polyol Synthesis ◽  
Heating Efficiency ◽  
Magnetic Heating

scholarly journals Low-Intensity Electromagnetic Millimeter Waves for Pain Therapy

2006 ◽  
Vol 3 (2) ◽  
pp. 201-207 ◽  
Author(s):  
Taras I. Usichenko ◽  
Hardy Edinger ◽  
Vasyl V. Gizhko ◽  
Christian Lehmann ◽  
Michael Wendt ◽  
...  
Keyword(s):  
Pain Relief ◽  
Methodological Quality ◽  
Large Scale ◽  
Case Series ◽  
Treatment Method ◽  
Rapid Onset ◽  
Acupuncture Points ◽  
Non Invasive ◽  
Review Criteria

Millimeter wave therapy (MWT), a non-invasive complementary therapeutic technique is claimed to possess analgesic properties. We reviewed the clinical studies describing the pain-relief effect of MWT. Medline-based search according to review criteria and evaluation of methodological quality of the retrieved studies was performed. Of 13 studies, 9 of them were randomized controlled trials (RCTs), only three studies yielded more than 3 points on the Oxford scale of methodological quality of RCTs. MWT was reported to be effective in the treatment of headache, arthritic, neuropathic and acute postoperative pain. The rapid onset of pain relief during MWT lasting hours to days after, remote to the site of exposure (acupuncture points), was the most characteristic feature in MWT application for pain relief. The most commonly used parameters of MWT were the MW frequencies between 30 and 70 GHz and power density up to 10 mW cm−2. The promising results from pilot case series studies and small-size RCTs for analgesic/hypoalgesic effects of MWT should be verified in large-scale RCTs on the effectiveness of this treatment method.

Enhancement of magnetic heating efficiency in size controlled MFe2O4 (M = Mn, Fe, Co and Ni) nanoassemblies

RSC Advances ◽  
2015 ◽  
Vol 5 (19) ◽  
pp. 14311-14321 ◽  
Author(s):  
Jeotikanta Mohapatra ◽  
Saumya Nigam ◽  
J. Gupta ◽  
A. Mitra ◽  
M. Aslam ◽  
...  
Keyword(s):  
Thermal Decomposition ◽  
Ethylene Glycol ◽  
Magnetic Nanoparticle ◽  
Metal Chloride ◽  
Heating Efficiency ◽  
Magnetic Heating ◽  
Size Controlled

The MFe2O4 magnetic nanoparticle nanoassemblies (MNNAs) have been synthesized via thermal decomposition of metal chloride in ethylene glycol (EG) in the presence of ethylenediamine (EDA).

Hierarchical Lichee-like Fe3O4 Assemblies and Their High Heating Efficiency in Magnetic Hyperthermia

2021 ◽  
Author(s):  
Wen-Yu Li ◽  
Wen-Tao Li ◽  
Bang-Quan Li ◽  
Li-Juan Dong ◽  
Tian-Hua Meng ◽  
...  
Keyword(s):  
Magnetic Hyperthermia ◽  
Heating Efficiency ◽  
High Heating

scholarly journals Inductive Thermal Effect of Ferrite Magnetic Nanoparticles

Materials ◽  
2019 ◽  
Vol 12 (19) ◽  
pp. 3208 ◽  
Author(s):  
Jeotikanta Mohapatra ◽  
Meiying Xing ◽  
J. Ping Liu
Keyword(s):  
Magnetic Properties ◽  
Magnetic Nanoparticles ◽  
Spinel Ferrite ◽  
Particle Interactions ◽  
Heat Induction ◽  
Heating Efficiency ◽  
Magnetic Parameters ◽  
Thermally Activated ◽  
Cell Functions ◽  
Magnetic Heating

Localized heat induction using magnetic nanoparticles under an alternating magnetic field is an emerging technology applied in areas including, cancer treatment, thermally activated drug release and remote activation of cell functions. To enhance the induction heating efficiency of magnetic nanoparticles, the intrinsic and extrinsic magnetic parameters influencing the heating efficiency of magnetic nanoparticles should be effectively engineered. This review covers the recent progress in the optimization of magnetic properties of spinel ferrite nanoparticles for efficient heat induction. The key materials factors for efficient magnetic heating including size, shape, composition, inter/intra particle interactions are systematically discussed, from the growth mechanism, process control to chemical and magnetic properties manipulation.

scholarly journals Role of zinc substitution in magnetic hyperthermia properties of magnetite nanoparticles: interplay between intrinsic properties and dipolar interactions

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Yaser Hadadian ◽  
Ana Paula Ramos ◽  
Theo Z. Pavan
Keyword(s):  
Magnetic Nanoparticles ◽  
Magnetite Nanoparticles ◽  
Linear Response Theory ◽  
Magnetic Hyperthermia ◽  
Superior Performance ◽  
Dipolar Interactions ◽  
Intrinsic Properties ◽  
Specific Loss ◽  
Heating Efficiency ◽  
Specific Loss Power

AbstractOptimizing the intrinsic properties of magnetic nanoparticles for magnetic hyperthermia is of considerable concern. In addition, the heating efficiency of the nanoparticles can be substantially influenced by dipolar interactions. Since adequate control of the intrinsic properties of magnetic nanoparticles is not straightforward, experimentally studying the complex interplay between these properties and dipolar interactions affecting the specific loss power can be challenging. Substituting zinc in magnetite structure is considered as an elegant approach to tune its properties. Here, we present experimental and numerical simulation results of magnetic hyperthermia studies using a series of zinc-substituted magnetite nanoparticles (ZnxFe1-xFe2O4, x = 0.0, 0.1, 0.2, 0.3 and 0.4). All experiments were conducted in linear regime and the results were inferred based on the numerical simulations conducted in the framework of the linear response theory. The results showed that depending on the nanoparticles intrinsic properties, interparticle interactions can have different effects on the specific loss power. When dipolar interactions were strong enough to affect the heating efficiency, the parameter σ = KeffV/kBT (Keff is the effective anisotropy and V the volume of the particles) determined the type of the effect. Finally, the sample x = 0.1 showed a superior performance with a relatively high intrinsic loss power 5.4 nHm2kg−1.

Triggered drug release from hybrid thermoresponsive nanoparticles using near infrared light

Nanomedicine ◽  
2020 ◽  
Vol 15 (3) ◽  
pp. 219-234 ◽  
Author(s):  
Isabel Ortiz de Solorzano ◽  
Martin Prieto ◽  
Gracia Mendoza ◽  
Victor Sebastian ◽  
Manuel Arruebo
Keyword(s):  
Drug Delivery ◽  
Gold Nanoparticles ◽  
Colloidal Stability ◽  
Near Infrared ◽  
Chemical Characterization ◽  
Infrared Light ◽  
Galvanic Replacement ◽  
Heating Efficiency ◽  
Hollow Gold Nanoparticles

Aim: Developing hybrid poly(N-isopropylacrylamide)-based nanogels decorated with plasmonic hollow gold nanoparticles for on-demand drug delivery and their physico-chemical characterization, bupivacaine loading and release ability upon light irradiation, and in vitro cell viability. Materials & methods: Hollow gold nanoparticles were prepared by galvanic replacement reaction; poly(N-isopropylacrylamide)-based nanogels were synthesized via precipitation polymerization and their electrostatic coupling was accomplished using poly(allylamine hydrochloride) as cationic polyelectrolyte linker. Results & conclusion: Colloidal stability of the resulted hybrid nanovectors was demonstrated under physiological conditions together with their fast response and excellent heating efficiency after light stimulation, indicating their potential use as triggered drug-delivery vectors. Moreover, their influence on cell metabolism and cell cycle under subcytotoxic doses were studied showing excellent cytocompatibility.

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