scholarly journals Effective charges and zeta potentials of oil in water microemulsions in the presence of Hofmeister salts

2018 ◽  
Vol 148 (22) ◽  
pp. 222817 ◽  
Author(s):  
Alexandre P. dos Santos ◽  
Yan Levin
Keyword(s):  
Zeta Potentials ◽  
Oil In Water ◽  
Effective Charges ◽  
Hofmeister Salts

Zeta potentials of gum arabic stabilised oil in water emulsions

1999 ◽  
Vol 13 (6) ◽  
pp. 459-465 ◽  
Author(s):  
M.L Jayme ◽  
D.E Dunstan ◽  
M.L Gee
Keyword(s):  
Gum Arabic ◽  
Zeta Potentials ◽  
Oil In Water

scholarly journals Synthesis, Characterization and Stress-Testing of a Novel Quillaja Saponin Stabilized Oil-in-Water Phytocannabinoid Nanoemulsion

2020 ◽  
Author(s):  
Abhinandan Banerjee ◽  
Justin Binder ◽  
Ryan Salama ◽  
John Trant
Keyword(s):  
Phase Separation ◽  
Stress Testing ◽  
Droplet Surface ◽  
Lipid Phase ◽  
Ambient Conditions ◽  
Zeta Potentials ◽  
Oil In Water ◽  
Cannabis Extract ◽  
Robust Systems ◽  
Quillaja Saponin

<div>This study describes the design, optimization, and stress-testing of a novel phytocannabinoid nanoemulsion generated using high-pressure homogenization. QNaturale®, a plant-derived commercial emulsifier containing quillaja saponin, was used to stabilize the lipid phase droplets in water. Optimization studies revealed that after 10 homogenization cycles at a pressure of 30,000 psi in the presence of 10 wt% QNaturale® (1.5 wt% quillaja saponin), average nanoemulsion droplet diameters were ca.</div><div>120 nm and average droplet surface zeta-potentials were ca. -30 mV for a lipid phase comprising 16.6 wt% CBD-enriched cannabis extract and 83.4 wt% carrier (soybean) oil. The optimized nanoemulsion proved to be stable to droplet agglomeration and phase separation upon storage under ambient conditions for 6 weeks, as well as under a variety of physical stressors such as heat, cold, dilution, and</div><div>carbonation. pH values under 2 and moderately high salt concentrations (> 100 mM), however, destabilized 0the CD<sub>CBD</sub> nanoemulsion, eventually leading to phase separation. Cannabis potency, determined by HPLC, was detrimentally affected by any changes in the nanoemulsion phase stability. Quillaja saponin stabilized cannabidiol (CBD)-enriched nanoemulsions are stable, robust systems even at low emulsifier concentrations, and are therefore significant from both a scientific as well as a commercial perspective.</div>

scholarly journals Synthesis, Characterization and Stress-Testing of a Novel Quillaja Saponin Stabilized Oil-in-Water Phytocannabinoid Nanoemulsion

2020 ◽  
Author(s):  
Abhinandan Banerjee ◽  
Justin Binder ◽  
Ryan Salama ◽  
John Trant
Keyword(s):  
Phase Separation ◽  
Stress Testing ◽  
Droplet Surface ◽  
Lipid Phase ◽  
Ambient Conditions ◽  
Zeta Potentials ◽  
Oil In Water ◽  
Cannabis Extract ◽  
Robust Systems ◽  
Quillaja Saponin

<div>This study describes the design, optimization, and stress-testing of a novel phytocannabinoid nanoemulsion generated using high-pressure homogenization. QNaturale®, a plant-derived commercial emulsifier containing quillaja saponin, was used to stabilize the lipid phase droplets in water. Optimization studies revealed that after 10 homogenization cycles at a pressure of 30,000 psi in the presence of 10 wt% QNaturale® (1.5 wt% quillaja saponin), average nanoemulsion droplet diameters were ca.</div><div>120 nm and average droplet surface zeta-potentials were ca. -30 mV for a lipid phase comprising 16.6 wt% CBD-enriched cannabis extract and 83.4 wt% carrier (soybean) oil. The optimized nanoemulsion proved to be stable to droplet agglomeration and phase separation upon storage under ambient conditions for 6 weeks, as well as under a variety of physical stressors such as heat, cold, dilution, and</div><div>carbonation. pH values under 2 and moderately high salt concentrations (> 100 mM), however, destabilized 0the CD<sub>CBD</sub> nanoemulsion, eventually leading to phase separation. Cannabis potency, determined by HPLC, was detrimentally affected by any changes in the nanoemulsion phase stability. Quillaja saponin stabilized cannabidiol (CBD)-enriched nanoemulsions are stable, robust systems even at low emulsifier concentrations, and are therefore significant from both a scientific as well as a commercial perspective.</div>

Nanoemulsions Loaded with Amphotericin B: Development, Characterization and Leishmanicidal Activity

2019 ◽  
Vol 25 (14) ◽  
pp. 1616-1622 ◽  
Author(s):  
Gabriela Muniz Félix Araújo ◽  
Gabriela Muniz Félix Araújo ◽  
Alana Rafaela Albuquerque Barros ◽  
Alana Rafaela Albuquerque Barros ◽  
João Augusto Oshiro-Junior ◽  
...  
Keyword(s):  
Amphotericin B ◽  
Average Diameter ◽  
Isopropyl Myristate ◽  
Neglected Diseases ◽  
Clinical Form ◽  
Hydrophobic Compounds ◽  
Internal Phase ◽  
Oil In Water ◽  
Spherical Structures ◽  
Lipid Formulations

Leishmaniasis is one of the most neglected diseases in the world. Its most severe clinical form, called visceral, if left untreated, can be fatal. Conventional therapy is based on the use of pentavalent antimonials and includes amphotericin B (AmB) as a second-choice drug. The micellar formulation of AmB, although effective, is associated with acute and chronic toxicity. Commercially-available lipid formulations emerged to overcome such drawbacks, but their high cost limits their widespread use. Drug delivery systems such as nanoemulsions (NE) have proven ability to solubilize hydrophobic compounds, improve absorption and bioavailability, increase efficacy and reduce toxicity of encapsulated drugs. NE become even more attractive because they are inexpensive and easy to prepare. The aim of this work was to incorporate AmB in NE prepared by sonicating a mixture of surfactants, Kolliphor® HS15 (KHS15) and Brij® 52, and an oil, isopropyl myristate. NE exhibited neutral pH, conductivity values consistent with oil in water systems, spherical structures with negative Zeta potential value, monomodal size distribution and average diameter of drug-containing droplets ranging from 33 to 132 nm. AmB did not modify the thermal behavior of the system, likely due to its dispersion in the internal phase. Statistically similar antileishmanial activity of AmB-loaded NE to that of AmB micellar formulation suggests further exploring them in terms of toxicity and effectiveness against amastigotes, with the aim of offering an alternative to treat visceral leishmaniasis.

Nanoemulsions- A better Approach for Anti Diabeticdrugs Delivering

2020 ◽  
Vol 17 ◽  
Author(s):  
V. Manimaran ◽  
Ponnurengam Malliappan Sivakumar ◽  
J. Narayanan ◽  
Shanmugam Parthasarathi ◽  
Pranav Kumar Prabhakar
Keyword(s):  
Aqueous Phase ◽  
Therapeutic Agent ◽  
Antidiabetic Drugs ◽  
Optical Behaviour ◽  
Antimicrobial Drugs ◽  
Drug Degradation ◽  
Oil In Water ◽  
Drug Technology ◽  
Human Use ◽  
Poor Absorption

: Conventional delivery of antidiabetic drugs faces many problems like poor absorption, low bioavailability, and drug degradation. Nanoemulsion is a unique drug technology which is very suitable for the delivery of antidiabetic drugs. In recent years the flaws of delivering anti-hypoglycaemic drugs have been overcome by choosing nanoemulsion drug technology. They are thermodynamically stable and also deliver the therapeutic agent for a longer duration. Generally, Nanoemulsions are made up of either oil-in-water or water-in-oil and size of the droplets is from fifty to thousand nanometer. Surfactants are critical substances which are added in the manufacturing of nanoemulsions. Only the surfactants which are approved for human use can be utilized in the manufacturing of nanoemulsions. Generally, the preparation of emulsions includes mixing of the aqueous phase and organic phase and using surfactant with proper agitation. Nanoemulsions are used for antimicrobial drugs, and they are also used in the prophylaxis of cancer, diabetics. Reduction in the droplet size may cause variation in the elastic and optical behaviour of nanoemulsions.

Plant Oil-Based Nanoemulsions: Preparation and Efficacy for Hair Treatment

2020 ◽  
Vol 04 ◽  
Author(s):  
Lívia Gonçalves Ferreira Rodrigues ◽  
Juliana Falcão Alves de Carvalho ◽  
Cristal dos Santos Cerqueira Pinto ◽  
Elisabete Pereira Santos ◽  
Claudia Regina Elias Mansur
Keyword(s):  
Human Hair ◽  
Mechanical Tests ◽  
Plant Oils ◽  
Plant Oil ◽  
Oil In Water ◽  
Hair Samples ◽  
Poly Ethylene Oxide ◽  
Treatment Objective ◽  
Poly Ethylene ◽  
Average Size

Background:: The use of polymers in hair care products is widespread, and silicones in particular are extensively used in cosmetic formulations. In addition, plant oils can also be used for hair treatment. Objective: In the present work, oil-in-water (O/W) nanoemulsions were prepared to repair chemical damage to human hair samples, to investigate the combined use of a silicone polyether copolymer (surfactant) that has a branch composed of poly(ethylene oxide) in its chains, and two types of plant oils: coconut and ojon oil. Materials and Methods:: Surfactant-oil-water formulations were obtained by ultrasonic processing. The nanoemulsions were then applied to human hair strands previously damaged with sodium hydroxide, to compare the treated strands with untreated ones. The efficacy of the formulations was investigated by scanning electron microscopy, thermogravimetric analysis and mechanical tests. Results and Discussion:: Stables nanoemulsions were obtained with average size of the dispersed droplets up to 400 nm. The micrographs suggest that the action mechanism of the nanoemulsions depends not only on the type of plant oil used and size of the droplets dispersed in the system, but also on the type of hair that receives the treatment. The thermal analysis showed that the use of nanoemulsion changed the temperature of keratin interconversion to higher values, which can make hair fibers more resistant to heat. Hair resistance was improved when comparing virgin samples to the damaged ones. Conclusion:: The nanoemulsions were efficient in the treatment of the hair samples, which showed a significant improvement of their mechanical properties.

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