Plasticization of poly(lactic acid) using different molecular weight of Poly(ethylene glycol)

2017 ◽  
Author(s):  
Athanasia Amanda Septevani ◽  
Samsul Bhakri
Keyword(s):  
Molecular Weight ◽  
Lactic Acid ◽  
Ethylene Glycol ◽  
Poly Lactic Acid ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene ◽  
Different Molecular Weight

Non-toxic polyester urethanes based on poly(lactic acid), poly(ethylene glycol) and lysine diisocyanate

2016 ◽  
Vol 32 (3) ◽  
pp. 225-241 ◽  
Author(s):  
Alena Pavelková ◽  
Pavel Kucharczyk ◽  
Zdenka Kuceková ◽  
Jiří Zedník ◽  
Vladimír Sedlařík
Keyword(s):  
Molecular Weight ◽  
Lactic Acid ◽  
Ethylene Glycol ◽  
Biomedical Applications ◽  
Hydrolytic Degradation ◽  
Chain Extension ◽  
Poly Lactic Acid ◽  
Side Reactions ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene

Poly(lactic acid)-based polymers are highly suitable for temporary biomedical applications, such as tissue support or drug delivery systems. Copolymers of different molecular weight based on poly(lactic acid) and poly(ethylene glycol) were prepared by polycondensation, catalysed by hydrochloric acid. A chain-extension reaction with l-lysine ethyl ester diisocyanate was employed afterwards to obtain polyester urethanes with enhanced properties. The GPC results showed that the molecular weights of the products reached about 50,000 g·mol−1 and the hydrolytic progress was rapid in the first 2 weeks; the drop in Mn equalled approximately 70%. Additionally, elemental analysis of the buffer medium proved that hydrolytic degradation was more rapid in the first stage. Tensile-strength testing revealed that ductility increased alongside reduced molecular weight of poly(ethylene glycol), also suggesting that polymer branching occurred due to side reactions of isocyanate. Based on the envisaged biomedical applications for these polymers, cytotoxicity tests were carried out and the cytotoxic effect was only moderate in the case of 100% polymer extract prepared according to ISO standard 10993-12. In their research, the authors focused on preparing metal-free, catalysed synthesis of polyester urethanes, which could prove useful to numerous biomedical applications.

The effect of poly(ethylene glycol) as plasticizer in blends of poly(lactic acid) and poly(butylene succinate)

2015 ◽  
Vol 133 (8) ◽  
pp. n/a-n/a ◽  
Author(s):  
Weraporn Pivsa-Art ◽  
Kazunori Fujii ◽  
Keiichiro Nomura ◽  
Yuji Aso ◽  
Hitomi Ohara ◽  
...  
Keyword(s):  
Lactic Acid ◽  
Ethylene Glycol ◽  
Poly Lactic Acid ◽  
Poly Ethylene Glycol ◽  
Butylene Succinate ◽  
Poly Ethylene

Biodegradable polymer blends of poly(lactic acid) and poly(ethylene glycol)

1997 ◽  
Vol 66 (8) ◽  
pp. 1495-1505 ◽  
Author(s):  
Mihir Sheth ◽  
R. Ananda Kumar ◽  
Vipul Dav� ◽  
Richard A. Gross ◽  
Stephen P. McCarthy
Keyword(s):  
Lactic Acid ◽  
Ethylene Glycol ◽  
Polymer Blends ◽  
Biodegradable Polymer ◽  
Poly Lactic Acid ◽  
Poly Ethylene Glycol ◽  
Poly Ethylene
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