Reactive oxygen species controllable non-thermal helium plasmas for evaluation of plasmid DNA strand breaks

2012 ◽  
Vol 101 (22) ◽  
pp. 224101 ◽  
Author(s):  
Jae Young Kim ◽  
Dong-Hoon Lee ◽  
John Ballato ◽  
Weiguo Cao ◽  
Sung-O Kim
Keyword(s):  
Reactive Oxygen Species ◽  
Plasmid Dna ◽  
Reactive Oxygen ◽  
Dna Strand Breaks ◽  
Oxygen Species ◽  
Strand Breaks ◽  
Dna Strand

scholarly journals Lipocalin produced by myelofibrosis cells affects the fate of both hematopoietic and marrow microenvironmental cells

Blood ◽  
2015 ◽  
Vol 126 (8) ◽  
pp. 972-982 ◽  
Author(s):  
Min Lu ◽  
Lijuan Xia ◽  
Yen-Chun Liu ◽  
Tsivia Hochman ◽  
Laetizia Bizzari ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen ◽  
Dna Strand Breaks ◽  
Oxygen Species ◽  
Strand Breaks ◽  
Cd34 Cells ◽  
Key Points ◽  
Dna Strand

Key Points LCN2 acts to generate reactive oxygen species, leading to increased DNA strand breaks and apoptosis in normal CD34+ cells. LCN2 promotes the generation of osteoblasts but diminishes adipogenesis, resembling the composition of the MF marrow microenvironment.

Stannous chloride mediates single strand breaks in plasmid DNA through reactive oxygen species formation

1999 ◽  
Vol 110 (3) ◽  
pp. 129-136 ◽  
Author(s):  
Flávio J.S. Dantas ◽  
Milton O. Moraes ◽  
José C.P. de Mattos ◽  
Roberto J.A.C. Bezerra ◽  
Elizeu F. Carvalho ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Plasmid Dna ◽  
Stannous Chloride ◽  
Reactive Oxygen ◽  
Single Strand ◽  
Oxygen Species ◽  
Reactive Oxygen Species Formation ◽  
Strand Breaks ◽  
Single Strand Breaks ◽  
Species Formation

scholarly journals Ginger Oleoresin Alleviated γ-Ray Irradiation-Induced Reactive Oxygen Species via the Nrf2 Protective Response in Human Mesenchymal Stem Cells

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Kaihua Ji ◽  
Lianying Fang ◽  
Hui Zhao ◽  
Qing Li ◽  
Yang Shi ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
Reactive Oxygen ◽  
Ros Generation ◽  
Oxygen Species ◽  
Ros Scavenging ◽  
Genes Encoding ◽  
Dna Strand

Unplanned exposure to radiation can cause side effects on high-risk individuals; meanwhile, radiotherapies can also cause injury on normal cells and tissues surrounding the tumor. Besides the direct radiation damage, most of the ionizing radiation- (IR-) induced injuries were caused by generation of reactive oxygen species (ROS). Human mesenchymal stem cells (hMSCs), which possess self-renew and multilineage differentiation capabilities, are a critical population of cells to participate in the regeneration of IR-damaged tissues. Therefore, it is imperative to search effective radioprotectors for hMSCs. This study was to demonstrate whether natural source ginger oleoresin would mitigate IR-induced injuries in human mesenchymal stem cells (hMSCs). We demonstrated that ginger oleoresin could significantly reduce IR-induced cytotoxicity, ROS generation, and DNA strand breaks. In addition, the ROS-scavenging mechanism of ginger oleoresin was also investigated. The results showed that ginger oleoresin could induce the translocation of Nrf2 to cell nucleus and activate the expression of cytoprotective genes encoding for HO-1 and NQO-1. It suggests that ginger oleoresin has a potential role of being an effective antioxidant and radioprotective agent.

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