Multicolor in vivo brain imaging with a microscope-coupled fiber-bundle microprobe

2012 ◽  
Vol 101 (23) ◽  
pp. 233702 ◽  
Author(s):  
Lyubov V. Doronina-Amitonova ◽  
Il'ya V. Fedotov ◽  
Olga Efimova ◽  
Maria Chernysheva ◽  
Andrei B. Fedotov ◽  
...  
Keyword(s):  
Brain Imaging ◽  
Fiber Bundle

In silico and in vivo study of radio-iodinated nefiracetam as a radiotracer for brain imaging in mice

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
M. H. Sanad ◽  
A. B. Farag ◽  
S. F. A. Rizvi
Keyword(s):  
Brain Imaging ◽  
Radiochemical Purity ◽  
High Yield ◽  
High Uptake ◽  
Oxidizing Agent ◽  
Receptor Ligand ◽  
Nootropic Agent ◽  
Biodistribution Studies

Abstract This study presents development and characterization of a radiotracer, [125I]iodonefiracetam ([125I]iodoNEF). Labeling with high yield and radiochemical purity was achieved through the formation of a [125I]iodoNEF radiotracer after investigating many factors like oxidizing agent content (chloramines-T (Ch-T)), substrate amount (Nefiracetam (NEF)), pH of reaction mixture, reaction time and temperature. Nefiracetam (NEF) is known as nootropic agent, acting as N-methyl-d-aspartic acid receptor ligand (NMDA). The radiolabeled compound was stable, and exhibited the logarithm of the partition coefficient (log p) value of [125I]iodonefiracetam as 1.85 (lipophilic). Biodistribution studies in normal mice confirmed the suitability of the [125I]iodoNEF radiotracer as a novel tracer for brain imaging. High uptake of 8.61 ± 0.14 percent injected dose/g organ was observed in mice

Identification and Morphologic Assessment of Mesocoelic Recess by In Vivo Human Brain Imaging With 7.0-T Magnetic Resonance Imaging

2011 ◽  
Vol 35 (4) ◽  
pp. 486-491 ◽  
Author(s):  
Na Rae Kim ◽  
Je G. Chi ◽  
Sang Han Choi ◽  
Young-Bo Kim ◽  
Hee Young Hwang ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Human Brain ◽  
Brain Imaging ◽  
Resonance Imaging

scholarly journals Cerebrovascular responses of the rat brain to noxious stimuli as examined by functional near-infrared whole brain imaging

2012 ◽  
Vol 107 (10) ◽  
pp. 2853-2865 ◽  
Author(s):  
Ji-Wei He ◽  
Fenghua Tian ◽  
Hanli Liu ◽  
Yuan Bo Peng
Keyword(s):  
Brain Imaging ◽  
Near Infrared ◽  
Small Animal ◽  
Nir Spectroscopy ◽  
Brain Regions ◽  
Anterior Cingulate ◽  
Hemodynamic Changes ◽  
Whole Brain ◽  
Brain Hemodynamics

While near-infrared (NIR) spectroscopy has been increasingly used to detect stimulated brain activities with an advantage of dissociating regional oxy- and deoxyhemoglobin concentrations simultaneously, it has not been utilized much in pain research. Here, we investigated and demonstrated the feasibility of using this technique to obtain whole brain hemodynamics in rats and speculated on the functional relevance of the NIR-based hemodynamic signals during pain processing. NIR signals were emitted and collected using a 26-optodes array on rat's dorsal skull surface after the removal of skin. Following the subcutaneous injection of formalin (50 μl, 3%) into a hindpaw, several isolable brain regions showed hemodynamic changes, including the anterior cingulate cortex, primary/secondary somatosensory cortexes, thalamus, and periaqueductal gray ( n = 6). Time courses of hemodynamic changes in respective regions matched with the well-documented biphasic excitatory response. Surprisingly, an atypical pattern (i.e., a decrease in oxyhemoglobin concentration with a concomitant increase in deoxyhemoglobin concentration) was seen in phase II. In a separate group of rats with innocuous brush and noxious pinch of the same area ( n = 11), results confirmed that the atypical pattern occurred more likely in the presence of nociception than nonpainful stimulation, suggesting it as a physiological substrate when the brain processes pain. In conclusion, the NIR whole brain imaging provides a useful alternative to study pain in vivo using small-animal models. Our results support the notion that neurovascular response patterns depend on stimuli, bringing attention to the interpretation of vascular-based neuroimaging data in studies of pain.

Implantable integrated photonic probe for light sheet brain imaging in vivo

2021 ◽  
Author(s):  
Nathan C. Lin ◽  
Xuan Zhao ◽  
Sakib Hassan ◽  
Ankit Raghuram ◽  
Ashok Veeraraghavan ◽  
...  
Keyword(s):  
Brain Imaging ◽  
Light Sheet

scholarly journals Individual identity and affective valence in marmoset calls: in vivo brain imaging with vocal sound playback

2018 ◽  
Vol 21 (3) ◽  
pp. 331-343 ◽  
Author(s):  
Masaki Kato ◽  
Chihiro Yokoyama ◽  
Akihiro Kawasaki ◽  
Chiho Takeda ◽  
Taku Koike ◽  
...  
Keyword(s):  
Brain Imaging ◽  
Individual Identity ◽  
Affective Valence

Preparation of Carbon Dots for Effective Fluorescence Imaging of Ovarian Cancer Cells and In Vivo Brain Imaging

NANO ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. 2050158
Author(s):  
Yinping Zhuang ◽  
Shaohui Zheng ◽  
Qi Liu ◽  
Kai Xu ◽  
Cuiping Han ◽  
...  
Keyword(s):  
Ovarian Cancer ◽  
Brain Imaging ◽  
Cancer Cells ◽  
In Vivo Imaging ◽  
Carbon Dots ◽  
Photoluminescence Property ◽  
Ovarian Cancer Cells ◽  
Animal Imaging ◽  
One Step

Fluorescent carbon dots (CDs) were prepared for targeted cancer imaging and in vivo imaging. The CDs were prepared via one-step hydrothermal pyrolysis of urea and sodium citrate dihydrate. The CDs revealed nice crystalline structure, excellent aqueous stability and good photoluminescence property and high quantum yield. The fluorescent images indicated that the anti-HE4-CDs were specifically internalized by the HO-8910 ovarian cancer cells. Furthermore, the CDs revealed vivid fluorescent signal in the animal imaging test and promising potential in brain imaging. Finally, the CDs also suggested low toxicity after treatment for 1 day, 7 days and 21 days. Therefore, the prepared CDs could be a promising imaging probe for targeted cancer cell imaging and in vivo imaging.

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