Molecular Rydberg transitions. XVIII. Vibronic doubling in methyl iodide

1980 ◽  
Vol 73 (10) ◽  
pp. 4925-4931 ◽  
Author(s):  
S. P. McGlynn ◽  
W. S. Felps ◽  
J. D. Scott ◽  
G.L. Findley
Keyword(s):  
Methyl Iodide ◽  
Rydberg Transitions

ChemInform Abstract: MOLECULAR RYDBERG TRANSITIONS. XVIII. VIBRONIC DOUBLING IN METHYL IODIDE

1981 ◽  
Vol 12 (11) ◽  
Author(s):  
S. P. MCGLYNN ◽  
W. S. FELPS ◽  
J. D. SCOTT ◽  
G. L. FINDLEY
Keyword(s):  
Methyl Iodide ◽  
Rydberg Transitions

Molecular Rydberg transitions. XII. Magnetic circular dichroism of methyl iodide

1978 ◽  
Vol 68 (10) ◽  
pp. 4678-4687 ◽  
Author(s):  
John D. Scott ◽  
W. Sid Felps ◽  
Gary L. Findley ◽  
Seán P. McGlynn
Keyword(s):  
Circular Dichroism ◽  
Methyl Iodide ◽  
Magnetic Circular Dichroism ◽  
Rydberg Transitions ◽  
Circular Dichroïsm

Femtosecond reaction dynamics of Rydberg states. Methyl iodide

1993 ◽  
Vol 214 (3-4) ◽  
pp. 281-289 ◽  
Author(s):  
M.H.M. Janssen ◽  
M. Dantus ◽  
H. Guo ◽  
A.H. Zewail
Keyword(s):  
Methyl Iodide ◽  
Rydberg States ◽  
Reaction Dynamics

scholarly journals Improved synthesis of SV2A targeting radiotracer [11C]UCB-J

2019 ◽  
Vol 4 (1) ◽  
Author(s):  
Johanna Rokka ◽  
Eva Schlein ◽  
Jonas Eriksson
Keyword(s):  
Methyl Iodide ◽  
Water Solution ◽  
Synthesis Method ◽  
Radiochemical Yield ◽  
Preparative Hplc ◽  
Step Method ◽  
Synaptic Density ◽  
Excellent Starting Point ◽  
Starting Point

Abstract Introduction [11C]UCB-J is a tracer developed for PET (positron emission tomography) that has high affinity towards synaptic vesicle glycoprotein 2A (SV2A), a protein believed to participate in the regulation of neurotransmitter release in neurons and endocrine cells. The localisation of SV2A in the synaptic terminals makes it a viable target for in vivo imaging of synaptic density in the brain. Several SV2A targeting compounds have been evaluated as PET tracers, including [11C]UCB-J, with the aim to facilitate studies of synaptic density in neurological diseases. The original two-step synthesis method failed in our hands to produce sufficient amounts of [11C]UCB-J, but served as an excellent starting point for further optimizations towards a high yielding and simplified one-step method. [11C]Methyl iodide was trapped in a clear THF-water solution containing the trifluoroborate substituted precursor, potassium carbonate and palladium complex. The resulting reaction mixture was heated at 70 °C for 4 min to produce [11C]UCB-J. Results After semi-preparative HPLC purification and reformulation in 10% ethanol/phosphate buffered saline, the product was obtained in 39 ± 5% radiochemical yield based on [11C]methyl iodide, corresponding to 1.8 ± 0.5 GBq at EOS. The radiochemical purity was > 99% and the molar activity was 390 ± 180 GBq/μmol at EOS. The product solution contained < 2 ppb palladium. Conclusions A robust and high yielding production method has been developed for [11C]UCB-J, suitable for both preclinical and clinical PET applications.

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