scholarly journals Numerical modeling of motion trajectory and deformation behavior of a cell in a nonuniform electric field

2011 ◽  
Vol 5 (2) ◽  
pp. 021101 ◽  
Author(s):  
Hua Li ◽  
Ting Ye ◽  
K. Y. Lam
Keyword(s):  
Numerical Modeling ◽  
Electric Field ◽  
Deformation Behavior ◽  
Nonuniform Electric Field ◽  
Motion Trajectory ◽  
A Cell

Breakdown of gas gaps in a nonuniform electric field at a subnanosecond voltage pulse rise time

2013 ◽  
Vol 58 (3) ◽  
pp. 370-374 ◽  
Author(s):  
A. M. Boichenko ◽  
V. F. Tarasenko ◽  
E. Kh. Baksht ◽  
A. G. Burachenko ◽  
M. V. Erofeev ◽  
...  
Keyword(s):  
Electric Field ◽  
Rise Time ◽  
Voltage Pulse ◽  
Nonuniform Electric Field ◽  
Pulse Rise Time

Factors Controlling Electropermeabilisation of Cell Membranes

2002 ◽  
Vol 1 (5) ◽  
pp. 319-327 ◽  
Author(s):  
M. P. Rols ◽  
M. Golzio ◽  
B. Gabriel ◽  
J. Teissié
Keyword(s):  
Cell Surface ◽  
Electric Field ◽  
Pulse Duration ◽  
Cell Membranes ◽  
Physical Parameters ◽  
Local Exchange ◽  
Physical Mechanisms ◽  
A Cell

Electric field pulses are a new approach for drug and gene delivery for cancer therapy. They induce a localized structural alteration of cell membranes. The associated physical mechanisms are well explained and can be safely controlled. A position dependent modulation of the membrane potential difference is induced when an electric field is applied to a cell. Electric field pulses with an overcritical intensity evoke a local membrane alteration. A free exchange of hydrophilic low molecular weight molecules takes place across the membrane. A leakage of cytosolic metabolites and a loading of polar drugs into the cytoplasm are obtained. The fraction of the cell surface which is competent for exchange is a function of the field intensity. The level of local exchange is strongly controlled by the pulse duration and the number of successive pulses. The permeabilised state is long lived. Its lifetime is under the control of the cumulated pulse duration. Cell viability can be preserved. Gene transfer is obtained but its mechanism is not a free diffusion. Plasmids are electrophoretically accumulated against the permeabilised cell surface and form aggregates due to the field effect. After the pulses, several steps follow: translocation to the cytoplasm, traffic to the nucleus and expression. Molecular structural and metabolic changes in cells remain mostly poorly understood. Nevertheless, while most studies were established on cells in culture ( in vitro), recent experiments show that similar effects are obtained on tissue ( in vivo). Transfer remains controlled by the physical parameters of the electrical treatment.

Electrostatic Dispensing of Dry Dielectric Materials

2001 ◽  
Vol 700 ◽  
Author(s):  
Malinda M. Tupper ◽  
Marjorie E. Chopinaud ◽  
Takamichi Ogawa ◽  
Michael J. Cima
Keyword(s):  
Electric Field ◽  
Field Intensity ◽  
Electric Field Intensity ◽  
Dielectric Materials ◽  
Nonuniform Electric Field ◽  
Sodium Fluorescein ◽  
Silica Spheres ◽  
Electrode Geometry ◽  
Wide Range ◽  
Silica Beads

AbstractDispensing micron-scale dielectric materials can be achieved through the use of dielectrophoresis. Electrodes are designed to create a nonuniform electric field. This method is expected to be applicable for transfer of a wide range of dielectric powders as well as small, shaped components. Small, 150 μm diameter silica spheres, as well as sodium fluorescein powder have been dispensed by this method. Selecting the appropriate electrode geometry and electric field intensity controls the amount collected. As little as 1.0 μg of sodium fluorescein powder, and as much as 16 mg of silica beads have been collected, and repeatability within 10 % of the total amount dispensed has been achieved.

scholarly journals Formation of single charged drops from a dielectric liquid jet in a nonuniform electric field.

1990 ◽  
Vol 16 (4) ◽  
pp. 700-705 ◽  
Author(s):  
Takashi Hibiki ◽  
Manabu Yamaguchi ◽  
Takashi Katayama
Keyword(s):  
Electric Field ◽  
Nonuniform Electric Field ◽  
Dielectric Liquid ◽  
Liquid Jet
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