scholarly journals Long term in vitro stability of fully integrated wireless neural interfaces based on Utah slant electrode array

2010 ◽  
Vol 96 (7) ◽  
pp. 073702 ◽  
Author(s):  
Asha Sharma ◽  
Loren Rieth ◽  
Prashant Tathireddy ◽  
Reid Harrison ◽  
Florian Solzbacher
Keyword(s):  
Electrode Array ◽  
Neural Interfaces ◽  
Fully Integrated ◽  
In Vitro Stability

scholarly journals The influence of Ag+, Zn2+ and Cu2+ exchanged zeolite on antimicrobial and long term in vitro stability of medical grade polyether polyurethane

2011 ◽  
Vol 5 (12) ◽  
pp. 1028-1040 ◽  
Author(s):  
P. Kaali ◽  
M. M. Perez-Madrigal ◽  
E. Stromberg ◽  
R. E. Aune ◽  
Gy. Czel ◽  
...  
Keyword(s):  
In Vitro Stability ◽  
Medical Grade

Effect of media composition on long-term in vitro stability of barium alginate and polyacrylic acid multilayer microcapsules

Biomaterials ◽  
2000 ◽  
Vol 21 (18) ◽  
pp. 1911-1917 ◽  
Author(s):  
A Gaumann ◽  
M Laudes ◽  
B Jacob ◽  
R Pommersheim ◽  
C Laue ◽  
...  
Keyword(s):  
Polyacrylic Acid ◽  
Media Composition ◽  
In Vitro Stability

scholarly journals Long-term reliability of Al2O3and Parylene C bilayer encapsulated Utah electrode array based neural interfaces for chronic implantation

2014 ◽  
Vol 11 (2) ◽  
pp. 026016 ◽  
Author(s):  
Xianzong Xie ◽  
Loren Rieth ◽  
Layne Williams ◽  
Sandeep Negi ◽  
Rajmohan Bhandari ◽  
...  
Keyword(s):  
Electrode Array ◽  
Neural Interfaces ◽  
Parylene C ◽  
Utah Electrode Array

Surface Modification of Polyimide Thin Films for Peripheral Invasive Neural Interfaces

2013 ◽  
Vol 7 (2) ◽  
Author(s):  
M. Righi ◽  
S. Bossi ◽  
GL. Puleo ◽  
G. Giudetti ◽  
P. Wieringa ◽  
...  
Keyword(s):  
Thin Films ◽  
Amino Acids ◽  
Surface Roughness ◽  
Neuronal Migration ◽  
Neural Interfaces ◽  
Toxic Materials ◽  
Novel Approach ◽  
Physiological Reactions

Despite recognized as one key component for establishing a functional electrical connection with nerves, neural invasive peripheral interfaces are still not optimal for long-term applications in humans. An improvement in the field of biocompatible and non-toxic materials is necessary to overcome the issues of interface/tissue mismatch and physiological reactions. The present work aimed to study, implement and characterize a novel approach to modify the surface of neural mi-crolectrodes basedon polyimide thin films. The purpose was to improve biocompatibility and to promote neuronal migration, growth and differentiation by increasing the surface roughness and endowing the surface with structure-reactivity for thiol-containing amino acids or peptides. L-Cysteine-Rhodamine B, used as a model biomolecule, was successfully grafted on samples surface via the introduction of cross-linkable vinyl groups on polyimide foils. Preliminary in vitro biological analysis allowed to evaluate the tendency of PC12 cells to adhere and to proliferate.

scholarly journals Hydroxyapatite and Titanium Dioxide Nanoparticles: Radiolabelling and In Vitro Stability of Prospective Theranostic Nanocarriers for 223Ra and 99mTc

Nanomaterials ◽  
2020 ◽  
Vol 10 (9) ◽  
pp. 1632
Author(s):  
Petra Suchánková ◽  
Ekaterina Kukleva ◽  
Eva Nykl ◽  
Pavel Nykl ◽  
Michal Sakmár ◽  
...  
Keyword(s):  
Titanium Dioxide ◽  
Titanium Dioxide Nanoparticles ◽  
Physiological Saline ◽  
Radiation Stability ◽  
Human Albumin ◽  
Bovine Blood ◽  
All Solutions ◽  
In Vitro Stability

Hydroxyapatite and titanium dioxide are widely used materials in a broad spectrum of branches. Due to their appropriate properties such as a large specific surface area, radiation stability or relatively low toxicity, they could be potentially used as nanocarriers for medicinal radionuclides for diagnostics and therapy. Two radiolabelling strategies of both nanomaterials were carried out by 99mTc for diagnostic purposes and by 223Ra for therapeutic purposes. The first one was the radionuclide sorption on ready-made nanoparticles and the second one was direct radionuclide incorporation into the structure of the nanoparticles. Achieved labelling yields were higher than 94% in all cases. Afterwards, in vitro stability tests were carried out in several solutions: physiological saline, bovine blood plasma, bovine blood serum, 1% and 5% human albumin solutions. In vitro stability studies were performed as short-term (59 h for 223Ra and 31 h for 99mTc) and long-term experiments (five half-lives of 223Ra, approx. 55 days). Both radiolabelled nanoparticles with 99mTc have shown similar released activities (about 20%) in all solutions. The best results were obtained for 223Ra radiolabelled titanium dioxide nanoparticles, where overall released activities were under 6% for 59 h study in all matrices and under 3% for 55 days in a long-term perspective.

scholarly journals Long termin vitrofunctional stability and recording longevity of fully integrated wireless neural interfaces based on the Utah Slant Electrode Array

2011 ◽  
Vol 8 (4) ◽  
pp. 045004 ◽  
Author(s):  
Asha Sharma ◽  
Loren Rieth ◽  
Prashant Tathireddy ◽  
Reid Harrison ◽  
Hermann Oppermann ◽  
...  
Keyword(s):  
Electrode Array ◽  
Neural Interfaces ◽  
Fully Integrated

Atomic Layer Deposited Al2O3 and Parylene C Bi-layer Encapsulation for Utah Electrode Array Based Neural Interfaces

2014 ◽  
Vol 1621 ◽  
pp. 259-265
Author(s):  
Xianzong Xie ◽  
Loren W. Rieth ◽  
Rohit Sharma ◽  
Sandeep Negi ◽  
Rajmohan Bhandari ◽  
...  
Keyword(s):  
Electrode Array ◽  
Atomic Layer ◽  
Implantable Devices ◽  
Neural Interfaces ◽  
Parylene C ◽  
Soaking Time ◽  
Encapsulation Method ◽  
Rf Signal ◽  
Utah Electrode Array

ABSTRACTLong-term functionality and stability of neural interfaces with complex geometries is one of the major challenges for chronic clinic applications due to lack of effective encapsulation. We present an encapsulation method that combines atomic layer deposited Al2O3 and Parylene C for encapsulation of biomedical implantable devices, focusing on its application on Utah electrode array based neural interfaces. The alumina and Parylene C bi-layer encapsulated wired Utah electrode array showed relatively stable impedance during the 960 equivalent soaking days at 37 °C in phosphate buffered solution. For the bi-layer coated wireless neural interfaces, the power-up frequency was constantly ∼ 910 MHz and the RF signal strength was stably around -73 dBm during equivalent soaking time of 1044 days at 37 °C (still under soak testing).

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