We study the charged pion transverse momentum(pT)spectra inp+pcollisions as a function of collision energysand event multiplicity using Tsallis distribution. This study gives an insight of the pion production process inp+pcollisions. The study covers pion spectra measured inp+pcollisions at SPS energies (6.27–17.27 GeV), RHIC energies (62.4 GeV and 200 GeV), and LHC energies (900 GeV, 2.76 TeV, and 7 TeV). The Tsallis parameters have been obtained and parameterized as a function ofs. The study suggests that as we move to higher energy more and more hard processes contribute to the spectra. We also study the charged pion spectra for different event multiplicities inp+pcollisions for LHC energies using Tsallis distribution. The variation of the Tsallis parameters as a function of event multiplicity has been obtained and their behavior is found to be independent of collision energy.