SLC5 Sodium-Anion Cotransporters and Renal Urate Transport

2007 ◽  
Author(s):  
David B. Mount ◽  
Charles Y. Kwon ◽  
Consuelo Plata ◽  
Michael F. Romero ◽  
Kambiz Zandi-Nejad
Keyword(s):  
Urate Transport

Renal Hypouricemia due to an Isolated Renal Defect of Urate Transport

Nephron ◽  
1988 ◽  
Vol 49 (1) ◽  
pp. 81-83 ◽  
Author(s):  
Ichiro Hisatome ◽  
Kazuhide Ogino ◽  
Makoto Saito ◽  
Jiro Miyamoto ◽  
Junichi Hasegawa ◽  
...  
Keyword(s):  
Renal Hypouricemia ◽  
Urate Transport

Urate transport in the proximal tubule: in vivo and vesicle studies

1985 ◽  
Vol 249 (6) ◽  
pp. F789-F798 ◽  
Author(s):  
A. M. Kahn ◽  
E. J. Weinman
Keyword(s):  
Proximal Tubule ◽  
Brush Border ◽  
Anion Exchanger ◽  
Basolateral Membrane ◽  
Membrane Vesicles ◽  
Transport Processes ◽  
Basolateral Membrane Vesicles ◽  
Urate Transport ◽  
Rat Proximal Tubule

The transport of urate in the mammalian nephron is largely confined to the proximal tubule. Depending on the species, net reabsorption or net secretion is observed. The rat, like the human and the mongrel dog, demonstrates net reabsorption of urate and has been the most extensively studied species. The unidirectional reabsorption and secretion of urate in the rat proximal tubule occur via a passive and presumably paracellular route and by a mediated transcellular route. The reabsorption of urate, and possibly its secretion, can occur against an electrochemical gradient. A variety of drugs and other compounds affect the reabsorption and secretion of urate. The effects of these agents depend on their site of application (luminal or blood), concentration, and occasionally their participation in transport processes that do not have affinity for urate. Recent studies with renal brush border and basolateral membrane vesicles from the rat and brush border vesicles from the dog have determined the mechanisms for urate transport across the luminal and antiluminal membranes of the proximal tubule cell. Brush border membrane vesicles contain an anion exchanger with affinity for urate, hydroxyl ion, bicarbonate, chloride, lactate, p-aminohippurate (PAH), and a variety of other organic anions. Basolateral membrane vesicles contain an anion exchanger with affinity for urate and chloride but not for PAH. Both membrane vesicle preparations also permit urate translocation by simple diffusion. A model for the transcellular reabsorption and secretion of urate in the rat proximal tubule is proposed. This model is based on the vesicle studies, and it can potentially explain the majority of urate transport data obtained with in vivo techniques.

scholarly journals Single kidney function: Early and late changes in urate transport after nephrectomy

1992 ◽  
Vol 41 (5) ◽  
pp. 1349-1355 ◽  
Author(s):  
Ifigenia Magoula ◽  
Georges Tsapas ◽  
Konstantinos Mavromatidis ◽  
Anastasios Katinios
Keyword(s):  
Kidney Function ◽  
Urate Transport ◽  
Single Kidney

scholarly journals Urate Transport via Paracellular Route across Epithelial Cells

2019 ◽  
Vol 42 (1) ◽  
pp. 43-49 ◽  
Author(s):  
Toru Kimura ◽  
Ai Tsukada ◽  
Toshiyuki Fukutomi ◽  
Kimiyoshi Ichida ◽  
Sumio Ohtsuki ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Urate Transport

Localization of urate transport in the nephron of mongrel and Dalmatian dog kidney

1959 ◽  
Vol 197 (3) ◽  
pp. 601-603 ◽  
Author(s):  
Richard H. Kessler ◽  
Klaus Hierholzer ◽  
Ruth S. Gurd
Keyword(s):  
Flow Analysis ◽  
Secretory Activity ◽  
Distal Segment ◽  
Free Flow ◽  
Proximal Segment ◽  
Urate Transport ◽  
Dog Kidney ◽  
Stop Flow ◽  
Urate Reabsorption ◽  
Dalmatian Dog

Localization of urate transport within the nephrons of mongrel and Dalmatian dogs was studied by stop-flow analysis. In mongrel dogs urate concentrations and clearance ratios were lowest in the segment in which PAH was secreted. Urate clearance ratios of 0.7 in free-flow samples were reduced to about 0.3 in stop-flow samples from the proximal segment. In the distal segment urate clearance ratios did not differ significantly from ratios obtained in free-flow. Probenecid, in doses sufficient to block PAH secretion, inhibited urate reabsorption thereby increasing urate clearance. In contrast to these findings with mongrel dogs, the Dalmatians exhibited weak but definite urate secretion within the proximal segment. The action of probenecid in this strain of dogs was to stop all proximal secretory activity for urate thereby reducing urate clearance. It was suggested that mongrel and Dalmatian dogs transport urate by systems that are identical except for direction of urate movement.

scholarly journals Comparative aspects of renal urate transport

1996 ◽  
Vol 49 (6) ◽  
pp. 1549-1551 ◽  
Author(s):  
William H. Dantzler
Keyword(s):  
Urate Transport
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