scholarly journals Single kidney function: Early and late changes in urate transport after nephrectomy

1992 ◽  
Vol 41 (5) ◽  
pp. 1349-1355 ◽  
Author(s):  
Ifigenia Magoula ◽  
Georges Tsapas ◽  
Konstantinos Mavromatidis ◽  
Anastasios Katinios
Keyword(s):  
Kidney Function ◽  
Urate Transport ◽  
Single Kidney

Quantification of Single-Kidney Function and Volume in Living Kidney Donors Using Dynamic Contrast-Enhanced MRI

2016 ◽  
Vol 207 (5) ◽  
pp. 1022-1030 ◽  
Author(s):  
Eli Eikefjord ◽  
Erling Andersen ◽  
Erlend Hodneland ◽  
Einar Svarstad ◽  
Arvid Lundervold ◽  
...  
Keyword(s):  
Kidney Function ◽  
Kidney Donors ◽  
Living Kidney Donors ◽  
Dynamic Contrast Enhanced Mri ◽  
Dynamic Contrast Enhanced ◽  
Enhanced Mri ◽  
Contrast Enhanced ◽  
Single Kidney ◽  
Contrast Enhanced Mri

scholarly journals Spontaneous one-kidney rats are more susceptible to develop hypertension by DOCA-NaCl and subsequent kidney injury compared with uninephrectomized rats

2016 ◽  
Vol 310 (10) ◽  
pp. F1054-F1064 ◽  
Author(s):  
Xuexiang Wang ◽  
Ashley C. Johnson ◽  
Jennifer M. Sasser ◽  
Jan M. Williams ◽  
Leah C. Solberg Woods ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Kidney Function ◽  
Time Course ◽  
Kidney Injury ◽  
Solitary Kidney ◽  
Course Evaluation ◽  
Significant Rise ◽  
Kidney Weight ◽  
Unilateral Renal Agenesis ◽  
Single Kidney

There is little clinical data of how hypertension may influence individuals with nephron deficiency in the context of being born with a single kidney. We recently developed a new rat model (the heterogeneous stock-derived model of unilateral renal agenesis rat) that is born with a single kidney and exhibits progressive kidney injury and decline in kidney function with age. We hypothesized that DOCA-salt would induce a greater increase in blood pressure and therefore accelerate the progression of kidney injury in rats born with a solitary kidney compared with rats that have undergone unilateral nephrectomy. Time course evaluation of blood pressure, kidney injury, and renal hemodynamics was performed in the following six groups of animals from weeks 13 to 18: 1) DOCA-treated rats with a solitary kidney (DOCA+S group), 2) placebo-treated rats with a solitary kidney, 3) DOCA-treated control rats with two kidneys (DOCA+C group), 4) placebo-treated control rats with two kidneys, 5) DOCA-treated rats with two kidneys that underwent uninephrectomy (DOCA+UNX8 group), and 6) placebo-treated rats with two kidneys that underwent uninephrectomy. DOCA+S rats demonstrated a significant rise ( P < 0.05) in blood pressure (192 ± 4 mmHg), proteinuria (205 ± 31 mg/24 h), and a decline in glomerular filtration rate (600 ± 42 μl·min−1·g kidney weight−1) relative to the DOCA+UNX8 (173 ± 3 mmHg, 76 ± 26 mg/24 h, and 963 ± 36 μl·min−1·g kidney weight−1) and DOCA+C (154 ± 2 mmHg, 7 ± 1 mg/24 h, and 1,484 ± 121 μl·min−1·g kidney weight−1) groups. Placebo-treated groups showed no significant change among the three groups. An assessment of renal injury markers via real-time PCR/Western blot analysis and histological analysis was concordant with the measured physiological parameters. In summary, congenital solitary kidney rats are highly susceptible to the induction of hypertension compared with uninephrectomized rats, suggesting that low nephron endowment is an important driver of elevated blood pressure, hastening nephron injury through the transmission of elevated systemic blood pressure and thereby accelerating decline in kidney function.

Single kidney function: Effect of acute protein and water loading on microalbuminuria

1988 ◽  
Vol 85 (5) ◽  
pp. 752-753
Author(s):  
Arlene Chapman ◽  
Alison S.M. Boyle ◽  
James F. Winchester
Keyword(s):  
Kidney Function ◽  
Water Loading ◽  
Single Kidney

Validity of Renal Split Function by Single Probe Renography in Hypertensive Patients

1988 ◽  
Vol 29 (3) ◽  
pp. 377-378 ◽  
Author(s):  
H. S. Thomsen ◽  
K. Hvid-Jacobsen ◽  
S. L. Nielsen
Keyword(s):  
Kidney Function ◽  
Gamma Camera ◽  
Sitting Position ◽  
Hypertensive Patients ◽  
Localization System ◽  
Single Probe ◽  
Split Function ◽  
Single Kidney

Single kidney function was determined both by single probe renography (131I hippuran) and gamma camera scintigraphy (99Tcm DMSA) in the sitting position in 42 consecutive patients who were referred to renography as a part of the workup of their hypertension. The positioning of the detectors turned out to be satisfactory in 83 per cent of the patients when compared with the determination of the split function at scintigraphy. This might be explained by the small 100 per cent isocount area of the probe (avoiding the effect of mobile kidneys) and by the 4-channel localization system.

P0750ASSOCIATION OF SERUM POTASSIUM LEVELS WITH RAPID KIDNEY FUNCTION DECLINE IN PATIENTS WITH CONGENITAL SINGLE KIDNEY

2020 ◽  
Vol 35 (Supplement_3) ◽  
Author(s):  
FLORICA GADALEAN ◽  
Florina Parv ◽  
Ligia Petrica ◽  
SILVIA VELCIOV ◽  
Cristina Anca Gluhovschi ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Glomerular Filtration Rate ◽  
Kidney Function ◽  
Serum Potassium ◽  
Filtration Rate ◽  
Estimated Glomerular Filtration Rate ◽  
Plasma Potassium ◽  
Lower Serum ◽  
Kidney Function Decline ◽  
Single Kidney

Abstract Background and Aims Hypokalemia is associated with progression of chronic kidney disease (CKD), although the possible underlying mechanisms are not well established. Several observational studies showed that low or even low to normal serum potassium levels predict the decline of kidney function in the general population. However, this hypothesis has not been yet investigated in patients with reduced nephron number as are congenital single kidney (cSK) patients. Our aim was to prospectively examine the association of plasma potassium with risk of rapid kidney function decline in a cSK patients’ cohort. Method A cohort of 67 consecutive patients with cSK (mean age = 44.4+/-15.7 years; males 29p (43.28%)), with a mean estimated glomerular filtration rate (eGFR) = 65.2+/-28 ml/min/1.73m2, were enrolled in this longitudinal observational study. We evaluated the associations of plasma potassium levels with longitudinal kidney function decline by estimated glomerular filtration rate (eGFR). The eGFR was assessed with CKD-EPI formula. The rapid kidney function decline was defined as a fall in eGFR of more than 5 ml/min/1.73 m2/year, according to the KDIGO guidelines. Results During a mean follow-up time of 20.16+/-9.3 months, 31.34% (21p) of patients presented decline of eGFR, with a fall of mean – 11.6+/-5.43 ml/min/1.73m2/year. In univariable regression analysis, the decline of eGFR was associated with baseline eGFR (R2=0.09, p=0.013), age (R2=0.31, p&lt;0.001), male gender (R2=0.14, p=0.001), arterial hypertension (R2=0.17, p=0.001), diabetes mellitus (R2=0.13, p=0.003), coronary artery disease (R2=0.12, p=0.005), uric acid (R2=0.23, p&lt;0.001), C-reactive protein (R2=0.09, p=0.011), proteinuria/24h (R2=0.14, p=0.002) and serum potassium (R2=0.29, p&lt;0.001). The serum potassium levels were significantly lower in the group with rapid decline of eGFR, with a mean of 3.62+/-0.41 mmol/L vs. 4.51+/-0.74 mmol/L, p&lt;0.001. In multivariable regression analysis, the association between lower serum potassium levels and risk of rapid eGFR decline remained significant (HR=1.65; 95%CI, 1.105-2.49; p=0.015). Conclusion These results suggest that lower serum potassium levels may play a role in rapid kidney function decline in the cSK population. Further research is required to assess whether the higher risk of kidney function decline in cSK individuals could be diminished when optimised serum potassium levels strictly.

Single kidney function: Effect of acute protein and water loading on microalbuminuria

1988 ◽  
Vol 84 (4) ◽  
pp. 711-717 ◽  
Author(s):  
Alessandro Amore ◽  
Rosanna Coppo ◽  
Dario Roccatello ◽  
Guido Martina ◽  
Cristiana Rollino ◽  
...  
Keyword(s):  
Kidney Function ◽  
Water Loading ◽  
Single Kidney

Effect Of Short-term, High-dose Creatine Supplementation On Kidney Function In A Young Man With A Single Kidney

2010 ◽  
Vol 42 ◽  
pp. 445
Author(s):  
Bruno Gualano ◽  
Desire F. Coelho ◽  
Marcelo T. Sapienza ◽  
Antonio C. Seguro ◽  
Antonio H. Lancha
Keyword(s):  
Kidney Function ◽  
Creatine Supplementation ◽  
High Dose ◽  
Short Term ◽  
Single Kidney
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