Free energy landscape analysis of two-dimensional dipolar solvent model at temperatures below and above the rotational freezing point

2006 ◽  
Vol 124 (12) ◽  
pp. 124508 ◽  
Author(s):  
Yohichi Suzuki ◽  
Yoshitaka Tanimura
Keyword(s):  
Free Energy ◽  
Freezing Point ◽  
Energy Landscape ◽  
Landscape Analysis ◽  
Free Energy Landscape ◽  
Two Dimensional ◽  
Solvent Model

Conformational modifications induced by internal tandem duplications on the FLT3 kinase and juxtamembrane domains

2019 ◽  
Vol 21 (34) ◽  
pp. 18467-18476 ◽  
Author(s):  
Guido Todde ◽  
Ran Friedman
Keyword(s):  
Free Energy ◽  
Protein Kinase ◽  
Molecular Dynamic ◽  
Energy Landscape ◽  
Landscape Analysis ◽  
Free Energy Landscape ◽  
Molecular Dynamic Simulations ◽  
Dynamic Simulations ◽  
Tandem Duplications

FLT3 is a protein kinase that becomes aberrantly expressed in certain leukaemias. Insertions in the form of tandem duplications activate the protein and were studied by molecular dynamic simulations and free energy landscape analysis.

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