Diffusion Coefficient Measurement with Glass Diaphragm Cells

1956 ◽  
Vol 24 (2) ◽  
pp. 470-471 ◽  
Author(s):  
J. R. White
Keyword(s):  
Diffusion Coefficient ◽  
Coefficient Measurement ◽  
Glass Diaphragm

scholarly journals In Vivo Experimental and Analytical Studies for Bevacizumab Diffusion Coefficient Measurement in the Rabbit Vitreous Humor

2020 ◽  
Author(s):  
Shuqi Zhang ◽  
Anita Penkova ◽  
Mark Humayun ◽  
Juan Carlos Martinez-Camarillo ◽  
Abegail C. Tadle ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Effective Diffusion ◽  
Drug Distribution ◽  
Vitreous Humor ◽  
Contour Method ◽  
Experimental Result ◽  
Coefficient Measurement ◽  
A New Technique ◽  
Best Fit

Abstract In order to measure the effective diffusion coefficient of Bevacizumab (Avastin, Genentech) in the vitreous humor, a new technique is developed based on the 'contour method' and in vivo OCT measurements. After injection of Bevacizumab-fluorescein conjugated compound solution into the rabbit eye, the contours of drug concentration distribution at the subsurface of injection were tracked over time. The 2D contours were extrapolated to 3D contours using reasonable assumptions and a numerically integrated analytical model was developed for the theoretical contours for the irregularly shaped drug distribution in the experimental result. By floating the diffusion coefficient, different theoretical contours were constructed and the least-squares best fit to the experimental contours was performed at each time point to get the best fit solution. The approach generated consistent diffusion coefficient values based on the experiments on four rabbit eyes over a period of 3 hours each, which gave , D=1.2±0.6×(?10?^(-6) ?cm?^2)/s and the corresponding theoretical contours matched well with the experimental contours. The quantitative measurement of concentration using OCT and fluorescein labeling gives a new approach for the "non-contact" in vivo drug distribution measurement within vitreous and other ocular tissues.

Diffusion coefficient measurement in a microfluidic analyzer using dual-beam microscale-refractive index gradient detection

2003 ◽  
Vol 1013 (1-2) ◽  
pp. 77-91 ◽  
Author(s):  
Colin D. Costin ◽  
Roy K. Olund ◽  
Bethany A. Staggemeier ◽  
Ana Kristine Torgerson ◽  
Robert E. Synovec
Keyword(s):  
Refractive Index ◽  
Diffusion Coefficient ◽  
Refractive Index Gradient ◽  
Dual Beam ◽  
Coefficient Measurement ◽  
Index Gradient

Diffusion Coefficient Measurement by Grazing Incidence X-ray Reflection in a Mo/Si Multilayer

2011 ◽  
Vol 38 (11) ◽  
pp. 1107002
Author(s):  
喻波 Yu Bo ◽  
李春 Li Chun ◽  
金春水 Jin Chunshui
Keyword(s):  
Diffusion Coefficient ◽  
Grazing Incidence ◽  
X Ray ◽  
Coefficient Measurement

scholarly journals PTPS-18APPARENT DIFFUSION COEFFICIENT MEASUREMENT IN PATIENTS WITH DIFFUSE INTRINSIC PONTINE GLIIOMA (DIPG): WORK-IN-PROGRESS

2015 ◽  
Vol 17 (suppl 5) ◽  
pp. v183.1-v183
Author(s):  
Shamseldeen Mahmoud ◽  
Tanya Tekautz ◽  
Erin Murphy ◽  
Aman Wadhwa ◽  
Johannes Wolff ◽  
...  
Keyword(s):  
Diffusion Coefficient ◽  
Work In Progress ◽  
Coefficient Measurement
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