Wide-field coherent anti-Stokes Raman scattering microscopy

2004 ◽  
Vol 84 (5) ◽  
pp. 816-818 ◽  
Author(s):  
Christoph Heinrich ◽  
Stefan Bernet ◽  
Monika Ritsch-Marte
APL Photonics ◽  
2018 ◽  
Vol 3 (11) ◽  
pp. 116104 ◽  
Author(s):  
Yujie Shen ◽  
Jizhou Wang ◽  
Kai Wang ◽  
Alexei V. Sokolov ◽  
Marlan O. Scully

2020 ◽  
Vol 45 (11) ◽  
pp. 3087
Author(s):  
Benjamin Doughty ◽  
Uvinduni I. Premadasa ◽  
John F. Cahill ◽  
Amber B. Webb ◽  
Jennifer L. Morrell-Falvey ◽  
...  

2021 ◽  
Author(s):  
Cheng Zong ◽  
Ran Cheng ◽  
Fukai Chen ◽  
Peng Lin ◽  
Meng Zhang ◽  
...  

Surface-enhanced Raman scattering (SERS) spectroscopy has been used extensively to study biology, chemistry, and materials. However, a point-by-point SERS mapping is time-consuming, taking minutes to hours for large-scale imaging. Here, we report a wide-field surface-enhanced coherent anti-Stokes Raman scattering (WISE-CARS) microscopy for monitoring nanotags in live cells and label-free detection of metabolic molecules. The WISE-CARS microscope achieves an imaging speed as fast as 120 frames per second for a large field of view of 130 microns X 130 microns. By spectral focusing of femtosecond lasers, a hyperspectral WISE-CARS stack of 120 frames can be acquired with a spectral resolution of 10 cm-1, where over 1 million Raman spectra are parallelly recorded within 0.5 seconds. As applications, we demonstrate time-lapse, 3D WISE-CARS imaging of nanotags in live cells as well as label-free detection of adenine released from S. aureus.


2015 ◽  
Vol 32 (7) ◽  
pp. 074209
Author(s):  
Yong-Gang Lv ◽  
Zi-Heng Ji ◽  
Da-Shan Dong ◽  
Ke-Bin Shi ◽  
Qi-Huang Gong

2007 ◽  
Vol 32 (13) ◽  
pp. 1941 ◽  
Author(s):  
I. Toytman ◽  
K. Cohn ◽  
T. Smith ◽  
D. Simanovskii ◽  
D. Palanker

2020 ◽  
Vol 45 (11) ◽  
pp. 3087
Author(s):  
Benjamin Doughty ◽  
Uvinduni I. Premadasa ◽  
John F. Cahill ◽  
Amber B. Webb ◽  
Jennifer L. Morrell-Falvey ◽  
...  

2007 ◽  
Vol 32 (23) ◽  
pp. 3468 ◽  
Author(s):  
Christoph Heinrich ◽  
Stefan Bernet ◽  
Monika Ritsch-Marte

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