The water–hydroxyl radical complex: A matrix isolation study

2003 ◽  
Vol 118 (17) ◽  
pp. 7797-7802 ◽  
Author(s):  
Anders Engdahl ◽  
Gunnar Karlström ◽  
Bengt Nelander
Keyword(s):  
Hydroxyl Radical ◽  
Matrix Isolation ◽  
Radical Complex

The Triplet Hydroxyl Radical Complex of Phosphorus Monoxide

2020 ◽  
Vol 59 (49) ◽  
pp. 21949-21953
Author(s):  
Xianxu Chu ◽  
Weiyu Qian ◽  
Bo Lu ◽  
Lina Wang ◽  
Jie Qin ◽  
...  
Keyword(s):  
Hydroxyl Radical ◽  
Radical Complex

Capture of the Sulfur Monoxide–Hydroxyl Radical Complex

2020 ◽  
Vol 142 (5) ◽  
pp. 2175-2179 ◽  
Author(s):  
Changyun Chen ◽  
Bo Lu ◽  
Xiaofang Zhao ◽  
Weiyu Qian ◽  
Jie Liu ◽  
...  
Keyword(s):  
Hydroxyl Radical ◽  
Radical Complex ◽  
Sulfur Monoxide

scholarly journals Rücktitelbild: The Triplet Hydroxyl Radical Complex of Phosphorus Monoxide (Angew. Chem. 49/2020)

2020 ◽  
Vol 132 (49) ◽  
pp. 22452-22452
Author(s):  
Xianxu Chu ◽  
Weiyu Qian ◽  
Bo Lu ◽  
Lina Wang ◽  
Jie Qin ◽  
...  
Keyword(s):  
Hydroxyl Radical ◽  
Radical Complex

The Triplet Hydroxyl Radical Complex of Phosphorus Monoxide

2020 ◽  
Vol 132 (49) ◽  
pp. 22133-22137
Author(s):  
Xianxu Chu ◽  
Weiyu Qian ◽  
Bo Lu ◽  
Lina Wang ◽  
Jie Qin ◽  
...  
Keyword(s):  
Hydroxyl Radical ◽  
Radical Complex

scholarly journals Back Cover: The Triplet Hydroxyl Radical Complex of Phosphorus Monoxide (Angew. Chem. Int. Ed. 49/2020)

2020 ◽  
Vol 59 (49) ◽  
pp. 22268-22268
Author(s):  
Xianxu Chu ◽  
Weiyu Qian ◽  
Bo Lu ◽  
Lina Wang ◽  
Jie Qin ◽  
...  
Keyword(s):  
Hydroxyl Radical ◽  
Back Cover ◽  
Radical Complex

Activation of cytochrome c to a peroxidase compound I-type intermediate by H2O2: relevance to redox signalling in apoptosis

2004 ◽  
Vol 71 ◽  
pp. 97-106 ◽  
Author(s):  
Mark Burkitt ◽  
Clare Jones ◽  
Andrew Lawrence ◽  
Peter Wardman
Keyword(s):  
Cytochrome C ◽  
Hydroxyl Radical ◽  
Redox Regulation ◽  
Chemotherapeutic Agents ◽  
Tyrosyl Radical ◽  
Compound I ◽  
Definitive Evidence ◽  
Enhanced Production ◽  
Physico Chemical

The release of cytochrome c from mitochondria during apoptosis results in the enhanced production of superoxide radicals, which are converted to H2O2 by Mn-superoxide dismutase. We have been concerned with the role of cytochrome c/H2O2 in the induction of oxidative stress during apoptosis. Our initial studies showed that cytochrome c is a potent catalyst of 2′,7′-dichlorofluorescin oxidation, thereby explaining the increased rate of production of the fluorophore 2′,7′-dichlorofluorescein in apoptotic cells. Although it has been speculated that the oxidizing species may be a ferryl-haem intermediate, no definitive evidence for the formation of such a species has been reported. Alternatively, it is possible that the hydroxyl radical may be generated, as seen in the reaction of certain iron chelates with H2O2. By examining the effects of radical scavengers on 2′,7′-dichlorofluorescin oxidation by cytochrome c/H2O2, together with complementary EPR studies, we have demonstrated that the hydroxyl radical is not generated. Our findings point, instead, to the formation of a peroxidase compound I species, with one oxidizing equivalent present as an oxo-ferryl haem intermediate and the other as the tyrosyl radical identified by Barr and colleagues [Barr, Gunther, Deterding, Tomer and Mason (1996) J. Biol. Chem. 271, 15498-15503]. Studies with spin traps indicated that the oxo-ferryl haem is the active oxidant. These findings provide a physico-chemical basis for the redox changes that occur during apoptosis. Excessive changes (possibly catalysed by cytochrome c) may have implications for the redox regulation of cell death, including the sensitivity of tumour cells to chemotherapeutic agents.

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