Robotic work station for microscale synthetic chemistry: On‐line absorption spectroscopy, quantitative automated thin‐layer chromatography, and multiple reactions in parallel

1988 ◽  
Vol 59 (6) ◽  
pp. 940-950 ◽  
Author(s):  
Jonathan S. Lindsey ◽  
L. Andrew Corkan ◽  
David Erb ◽  
Gary J. Powers
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Absorption Spectroscopy ◽  
Synthetic Chemistry ◽  
Work Station ◽  
Multiple Reactions ◽  
Line Absorption ◽  
On Line ◽  
Layer Chromatography

PREPARATION, THIN LAYER CHROMATOGRAPHY, AND ULTRAVIOLET SPECTRA OF SOME O-BENZYL DERIVATIVES OF D-GLUCOSE

1963 ◽  
Vol 41 (7) ◽  
pp. 1801-1806 ◽  
Author(s):  
M. E. Tate ◽  
C. T. Bishop
Keyword(s):  
Thin Layer ◽  
Thin Layer Chromatography ◽  
Absorption Spectroscopy ◽  
Preparative Method ◽  
New Method ◽  
Hydroxyl Groups ◽  
Good Criterion ◽  
Ultraviolet Absorption Spectroscopy ◽  
Layer Chromatography ◽  
Derivatives Of

A new method for benzylation of carbohydrates has been developed which facilitated complete substitution of hydroxyl groups in one of the compounds prepared. Thin layer chromatography provides a good criterion of purity and is also a preparative method for separation of identifiable amounts of O-benzyl derivatives of carbohydrates. The number of benzyl groups in a compound can be determined by ultraviolet absorption spectroscopy. The following compounds were prepared, some of which have not been reported previously: benzyl-2,3,4,6-tetra-O-benzyl-α-D-glucoside; benzyl 2,3,4,6-tetra-O-benzyl-β-D-glucoside; methyl 2,3,4,6-tetra-O-benzyl-α-D-glucoside; 2,3,4,6-tetra-O-benzyl-α-D-glucose; l-O-(p-nitro-benzoyl)-2,3,4,6-tetra-O-benzyl-α-D-glucose; octa-O-benzyl sucrose; 3,5-di-O-benzyl-1,2-O-cyclohexylidene-α-D-xylose.

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