Treatment of Early Childhood Medulloblastoma by Postoperative Chemotherapy Alone

2005 ◽  
Vol 352 (10) ◽  
pp. 978-986 ◽  
Author(s):  
Stefan Rutkowski ◽  
Udo Bode ◽  
Frank Deinlein ◽  
Holger Ottensmeier ◽  
Monika Warmuth-Metz ◽  
...  
Keyword(s):  
Early Childhood ◽  
Postoperative Chemotherapy ◽  
Childhood Medulloblastoma

scholarly journals Treatment of Early Childhood Medulloblastoma by Postoperative Chemotherapy Alone—A Critical Review

2009 ◽  
Vol 3 ◽  
pp. CMO.S392 ◽  
Author(s):  
Ricardo J. Komotar ◽  
Marc L. Otten ◽  
Matthew C. Garrett ◽  
Richard C.E. Anderson
Keyword(s):  
Early Childhood ◽  
Critical Review ◽  
Postoperative Chemotherapy ◽  
Childhood Medulloblastoma

scholarly journals Treatment of early childhood medulloblastoma by postoperative chemotherapy and deferred radiotherapy

2009 ◽  
Vol 11 (2) ◽  
pp. 201-210 ◽  
Author(s):  
Stefan Rutkowski ◽  
Nicolas Ulrich Gerber ◽  
Katja von Hoff ◽  
Astrid Gnekow ◽  
Udo Bode ◽  
...  
Keyword(s):  
Early Childhood ◽  
Postoperative Chemotherapy ◽  
Childhood Medulloblastoma

Survival and Prognostic Factors of Early Childhood Medulloblastoma: An International Meta-Analysis

2010 ◽  
Vol 28 (33) ◽  
pp. 4961-4968 ◽  
Author(s):  
Stefan Rutkowski ◽  
Katja von Hoff ◽  
Angela Emser ◽  
Isabella Zwiener ◽  
Torsten Pietsch ◽  
...  
Keyword(s):  
Early Childhood ◽  
Prognostic Factors ◽  
Meta Analysis ◽  
Large Cell ◽  
Study Groups ◽  
National Study ◽  
Incomplete Resection ◽  
Histologic Subtype ◽  
Prospective Trials ◽  
Childhood Medulloblastoma

Purpose To assess the prognostic role of clinical parameters and histology in early childhood medulloblastoma. Patients and Methods Clinical and histologic data from 270 children younger than age 5 years diagnosed with medulloblastoma between March 1987 and July 2004 and treated within prospective trials of five national study groups were centrally analyzed. Results Two hundred sixty children with medulloblastoma and specified histologic subtype were eligible for analysis (median age, 1.89 years; median follow-up, 8.0 years). Rates for 8-year event-free survival (EFS) and overall survival (OS) were 55% and 76%, respectively, in 108 children with desmoplastic/nodular medulloblastoma (DNMB) or medulloblastoma with extensive nodularity (MBEN); 27% and 42%, respectively, in 145 children with classic medulloblastoma (CMB); and 14% and 14%, respectively, in seven children with large-cell/anaplastic (LC/A) medulloblastoma (P < .001). Histology (DNMB/MBEN: hazard ratio [HR], 0.44; 95% CI, 0.31 to 0.64; LC/A medulloblastoma: HR, 2.27; 95% CI, 0.95 to 5.54; P < .001 compared with CMB), incomplete resection and metastases (M0R1: HR, 1.86; 95% CI, 1.29 to 2.80; M+: HR, 2.28; 95% CI, 1.50 to 3.46; P < .001 compared with M0R0), and national group were independent prognostic factors for EFS, and OS. The HRs for OS ranged from 0.14 for localized M0 and DNMB/MBEN to 13.67 for metastatic LC/A medulloblastoma in different national groups. Conclusion Our results confirm the high frequency of desmoplastic variants of medulloblastomas in early childhood and histopathology as a strong independent prognostic factor. A controlled de-escalation of treatment may be appropriate for young children with DNMB and MBEN in future clinical trials.

New stratification for early childhood medulloblastoma

2018 ◽  
Vol 1 ◽  
pp. 10-10
Author(s):  
Lea Guerrini-Rousseau ◽  
Jacques Grill ◽  
Christelle Dufour
Keyword(s):  
Early Childhood ◽  
Childhood Medulloblastoma
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