Low-Carbohydrate Diet and Coronary Heart Disease in Women

Background: Alternate day fasting combined with a low carbohydrate diet (ADF-LC) is an effective weight loss regimen. Whether the weight loss induced by ADF-LC can improve sleep, remains unknown. Objective: This study examined the effect an ADF-LC diet on sleep quality, duration, insomnia severity and the risk of obstructive sleep apnea. Methods: Adults with obesity (n = 31) participated in ADF (600 kcal “fast day”; ad libitum intake “feast day”) with a low-carbohydrate diet (30% carbohydrates, 35% protein, and 35% fat). The 6-month trial consisted of a 3-month weight loss period followed by a 3-month weight maintenance period. Results: Reductions in body weight (−5 ± 1 kg, p < 0.001) and fat mass (−4 ± 1 kg, p < 0.01) were noted during the weight loss period, and these reductions were sustained during the weight maintenance period. Lean mass and visceral fat remained unchanged. The Pittsburgh Sleep Quality Index (PSQI) score indicated poor sleep quality at baseline (6.4 ± 0.7) with no change by month 3 or 6, versus baseline. ISI score indicated subthreshold insomnia at baseline (8.5 ± 1.0), with no change by month 3 or 6, versus baseline. The percent of subjects with high risk of obstructive sleep apnea at baseline was 45%, with no change by month 3 or 6. Wake time, bedtime, and sleep duration remained unchanged. Conclusion: The ADF-LC diet does not impact sleep quality, duration, insomnia severity or the risk of obstructive sleep apnea in adults with obesity.

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The low-carbohydrate-diet score is associated with resting metabolic rate: an epidemiologic study among Iranian adults

Journal of Diabetes & Metabolic Disorders ◽

10.1007/s40200-021-00832-0 ◽

2021 ◽

Author(s):

Saba Mohammadpour ◽

Parivash Ghorbaninejad ◽

Hossein Shahinfar ◽

Mojdeh Ebaditabar ◽

Nadia Babaei ◽

...

Keyword(s):

Metabolic Rate ◽

Resting Metabolic Rate ◽

Epidemiologic Study ◽

Carbohydrate Diet ◽

Low Carbohydrate Diet ◽

Low Carbohydrate ◽

Diet Score

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LOW NITROGEN METABOLISM WITH LOW CARBOHYDRATE DIET IN DIABETES

Journal of Biological Chemistry ◽

10.1016/s0021-9258(18)85135-3 ◽

1924 ◽

Vol 61 (2) ◽

pp. 355-363

Author(s):

Karl Petrén

Keyword(s):

Nitrogen Metabolism ◽

Carbohydrate Diet ◽

Low Carbohydrate Diet ◽

Low Carbohydrate ◽

Low Nitrogen

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Circulating inflammatory markers may mediate the relationship between low carbohydrate diet and circadian rhythm in overweight and obese women

BMC Women s Health ◽

10.1186/s12905-021-01240-5 ◽

2021 ◽

Vol 21 (1) ◽

Author(s):

Atefeh Tavakoli ◽

Atieh Mirzababaei ◽

Forough Sajadi ◽

Khadijeh Mirzaei

Keyword(s):

Circadian Rhythm ◽

Inflammatory Markers ◽

Transforming Growth Factor ◽

Overweight And Obesity ◽

Obese Women ◽

Carbohydrate Diet ◽

Low Carbohydrate Diet ◽

Low Carbohydrate ◽

Galectin 3 ◽

Morning Type

Abstract Background Low carbohydrate diet (LCD) can improve inflammation and obesity and also circadian rhythm disorders can lead to increased inflammation in obese individuals. The purpose of this study is to evaluate the association between adherence of LCD and circadian rhythm mediated by inflammatory markers including transforming growth factor-β (TGF-β), interleukin-1β (IL-1β) and Galectin-3 in overweight and obese women. Methods 304 women affected by overweight and obesity were enrolled. We evaluated LCD scores by Semi-quantitative food frequency questionnaire (FFQ) of 147 items. The morning-evening questionnaire (MEQ) was applied to evaluate the circadian rhythm. Biochemical parameters such as inflammatory markers and anthropometric components were assessed. Results There was a negative significant correlation between adherence of LCD and circadian rhythm status. In other words, as the LCD scores increased, the odds of circadian rhythm disturbance in intermediate group and morning type persons decreased compared to evening type. It was showed that, IL-1β and Galectin-3 in intermediate and morning type groups, destroyed the significance of this relationship and may be considered as mediating markers. Conclusion Adherence of LCD can improve the circadian rhythm by reducing levels of inflammatory markers and may be considered as a treatment for obesity.

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