Grave's Eye Disease Developing Following Radioiodine Treatment for Toxic Nodular Goitre

2007 ◽  
Vol 115 (07) ◽  
pp. 471-473 ◽  
Author(s):  
A. Tahrani ◽  
S. Rangan ◽  
P. Moulik
Keyword(s):  
Eye Disease ◽  
Radioiodine Treatment ◽  
Nodular Goitre ◽  
Toxic Nodular Goitre

Serum thyroglobulin, its autoantibody and thyroid stimulating antibodies in the endocrine exophthalmos

1981 ◽  
Vol 96 (2) ◽  
pp. 192-198 ◽  
Author(s):  
Ulla Feldt Rasmussen ◽  
Axel Kemp ◽  
Karine Bech ◽  
Stig Nistrup Madsen ◽  
John Date
Keyword(s):  
Eye Disease ◽  
Graves Disease ◽  
Thyroid Autoantibodies ◽  
Serum Concentrations ◽  
Serum Thyroglobulin ◽  
Nodular Goitre ◽  
Thyroglobulin Antibodies ◽  
Thyroid Stimulating Antibodies ◽  
Persistent Elevation ◽  
Toxic Nodular Goitre

Abstract. Serum concentrations of thyroglobulin, its antibody, and thyroid stimulating antibodies were studied in 32 patients referred to a department of eye-diseases for exophthalmos. Twenty-three of the patients were or had been medically treated for Graves' disease, one had toxic nodular goitre, one subclinical myxoedema, three euthyroid exophthalmos and four were shown to have non-endocrine eye-disease. In patients with medically treated Graves' disease serum thyroglobulin was significantly elevated (P < 0.02), the still toxic patients accounting for the highest values. Both thyroid stimulating and thyroglobulin antibodies were detectable in 4 of 18 patients. The rest of the patients had normal concentrations of thyroglobulin and undetectable thyroid stimulating antibodies, but 3 patients had measurable thyroglobulin antibodies. In Graves' patients there was no correlation between serum concentrations of thyroid stimulating antibodies and thyroglobulin, and no clear difference between the frequency of thyroid stimulating or thyroglobulin antibodies in the patients with persistent elevation of circulating thyroid hormones and those remaining euthyroid. A relation between the thyroid autoantibodies, thyroglobulin and the thyroid hormonal level or severity of the exophthalmic state could not be demonstrated. It is suggested that hyperthyroidism and exophthalmos are separate disorders, and immunological phenomena probably involved in the pathogenesis of exophthalmos associated with Graves' disease appear to be reflected only locally.

The efficacy of radioiodine therapy in patients with non-toxic nodular goitre with large cold nodule

2015 ◽  
Author(s):  
Saeid Abdelrazek ◽  
Piotr Szumowski ◽  
Katrzyna Siewko ◽  
Janusz Mysliwiec ◽  
Malgorzata Szelachowska ◽  
...  
Keyword(s):  
Radioiodine Therapy ◽  
Nodular Goitre ◽  
Toxic Nodular Goitre ◽  
Cold Nodule

Enzyme-linked immunosorbent assay of autoantibodies reacting with thyroid plasma membrane antigens in sera of patients with autoimmune thyroid diseases

1986 ◽  
Vol 113 (2) ◽  
pp. 255-260 ◽  
Author(s):  
Andrzej Gardas ◽  
Kathleen L. Rives
Keyword(s):  
Plasma Membrane ◽  
Immunosorbent Assay ◽  
Lupus Erythematosus ◽  
Antithyroid Drug ◽  
Cross Reactivity ◽  
Enzyme Linked Immunosorbent Assay ◽  
Autoimmune Thyroid Diseases ◽  
Nodular Goitre ◽  
Membrane Antigens ◽  
Toxic Nodular Goitre

Abstract. A sensitive and specific enzyme-linked immunosorbent assay (ELISA) for the detection of autoantibodies reacting with thyroid plasma membrane antigens has been established. Autoantibodies reacting with thyroid plasma membrane antigens were detected by the ELISA in 95% of untreated hyperthyroid Graves', 68% of antithyroid drug-treated Graves' up to four months of the therapy, in 62% of Hashimoto's thyroiditis and in 8.9% of toxic nodular goitre. The ELISA was negative in 100% healthy blood donors, 100% non-toxic nodular goitre, in 12 patients with rheumatoid arthritis, 18 patients with scleroderma and 94% of patients with systemic lupus erythematosus. The mean value of autoantibodies titre was higher in untreated hyperthyroid Graves' (1:84 000) and lowest in positive patients with autoimmune disease of non-thyroid origin (1:4000). The cross-reactivity of antimicrosomal antigen antibodies was below 10%; there was no influence of antithyroglobulin antibodies on the ELISA; and most of the autoantibodies react with plasma membrane antigens different from the TSH binding sites.

Development of hypothyroidism during long-term follow-up of patients with toxic nodular goitre after radioiodine therapy

2012 ◽  
Vol 76 (2) ◽  
pp. 297-303 ◽  
Author(s):  
Deniz Kahraman ◽  
Christian Keller ◽  
Christina Schneider ◽  
Wolfgang Eschner ◽  
Ferdinand Sudbrock ◽  
...  
Keyword(s):  
Radioiodine Therapy ◽  
Nodular Goitre ◽  
Long Term Follow Up ◽  
Toxic Nodular Goitre

Toxic nodular goitre in the cat

1982 ◽  
Vol 23 (1) ◽  
pp. 1-12 ◽  
Author(s):  
MARGARETHE HOENIG ◽  
MICHAEL H. GOLDSCHMIDT ◽  
DUNCAN C. FERGUSON ◽  
KAARON KOCH ◽  
MICHAEL J. EYMONTT
Keyword(s):  
Nodular Goitre ◽  
Toxic Nodular Goitre

Is Paranodular, Grossly Normal Thyroid Tissue from Patients with Non-Toxic Nodular Goitre Really Normal?

1984 ◽  
Vol 16 (09) ◽  
pp. 504-505
Author(s):  
M. Solter ◽  
D. Tišlarić ◽  
M. Dominis ◽  
M. Sekso ◽  
B. Pegan ◽  
...  
Keyword(s):  
Thyroid Tissue ◽  
Normal Thyroid Tissue ◽  
Nodular Goitre ◽  
Normal Thyroid ◽  
Toxic Nodular Goitre

Thyroid Function after Medical and Surgical Treatment of Thyrotoxicosis and Non-Toxic Nodular Goitre

1975 ◽  
Vol 48 (1) ◽  
pp. 3P-4P
Author(s):  
N. W. Oakley ◽  
R. D. Simpson ◽  
F. M. Brooke ◽  
D. Burnett ◽  
T. F. Woods ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Thyroid Function ◽  
Nodular Goitre ◽  
Toxic Nodular Goitre

IODIDE-PEROXIDASE ACTIVITY IN HUMAN THYROID. I. STUDIES ON NON-TOXIC NODULAR GOITRE

1969 ◽  
Vol 62 (2) ◽  
pp. 193-198 ◽  
Author(s):  
H. Niepomniszcze ◽  
N. Altschuler ◽  
M. H. Korob ◽  
O. J. Degrossi
Keyword(s):  
Enzymatic Activity ◽  
Peroxidase Activity ◽  
Histological Diagnosis ◽  
Human Thyroid ◽  
Enzymatic System ◽  
Iodide Uptake ◽  
Nodular Goitre ◽  
Nodular Tissue ◽  
Toxic Nodular Goitre

ABSTRACT Eighteen nodules from thirteen patients with non-toxic nodular goitre were studied. The nodules were classified, according to the 131I scintiscanner, into »cold« and »warm« types. The histological diagnosis of all the glands was multinodular colloid goitre. An enzymatic system with iodide-peroxidase activity was prepared from nodular tissue obtained by surgical thyroidectomy. The enzymatic activity was determined by spectrophotometry at 287.5 nm by measuring the formation of triiodide ion. The group of »cold« nodules showed an average of 333 units of enzymatic activity and the »warm« nodules 940 units. The significance of the correlation between the capacity for iodide-uptake, the iodide-peroxidase activity and the involution of the metabolic steps in the nodular goitre is discussed.

STATISTICAL EVALUATION OF SYMPTOMS AND CLINICAL SIGNS IN THE DIAGNOSIS OF HYPERTHYROIDISM

1969 ◽  
Vol 62 (4_Suppla) ◽  
pp. S37-S42
Author(s):  
B.-A. Lamberg ◽  
O. P. Heinonen ◽  
A. Aro ◽  
M. Viherkoski ◽  
P. Knekt
Keyword(s):  
Nervous System ◽  
Statistical Evaluation ◽  
Clinical Signs ◽  
Control Group ◽  
Nodular Goitre ◽  
The Difference ◽  
Hyperthyroid Patients ◽  
Symptoms And Signs ◽  
Toxic Nodular Goitre ◽  
Stimulation Of

ABSTRACT The occurrence of 15 symptoms and 11 clinical signs was studied in 101 hyperthyroid patients and 106 euthyroid subjects. The hyperthyroid group comprised 50 patients with toxic diffuse goitre and 51 with toxic nodular goitre. The control group included 31 subjects with non-toxic goitre. The symptoms and signs were registered in a standardised manner. The difference in the frequency of each symptom and sign between the hyperthyroid and the control group was analysed statistically. The most discriminatory were the symptoms and signs related to excessive production of heat and to stimulation of the nervous system. The results were mostly in agreement with those of the few previously existing reports. Lid signs, however, were in both groups less frequent than in a British material. The need for standardisation in registration of symptoms and signs is emphasized.

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