Metabolism of Carcinogenic Nitrosamines in the Rat and Human Esophagus and Induction of Esophageal Adenocarcinoma in Rats

Endoscopy ◽  
1993 ◽  
Vol 25 (09) ◽  
pp. 627-631 ◽  
Author(s):  
S. S. Mirvish ◽  
Q. Huang ◽  
S. C. Chen ◽  
D. F. Birt ◽  
G. W. B. Clark ◽  
...  
Keyword(s):  
Esophageal Adenocarcinoma ◽  
Human Esophagus

scholarly journals Review: Experimental models for Barrett's esophagus and esophageal adenocarcinoma

2012 ◽  
Vol 302 (11) ◽  
pp. G1231-G1243 ◽  
Author(s):  
Katherine S. Garman ◽  
Roy C. Orlando ◽  
Xiaoxin Chen
Keyword(s):  
Barrett’S Esophagus ◽  
Esophageal Adenocarcinoma ◽  
Barrett's Esophagus ◽  
Experimental Models ◽  
Model Systems ◽  
Esophageal Injury ◽  
Cell Culture Systems ◽  
Ideal System ◽  
Screening Strategies ◽  
Human Esophagus

Several different cell culture systems and laboratory animal models have been used over the years to study Barrett's esophagus (BE) and esophageal adenocarcinoma (EAC). Most of the existing models have key differences with the human esophagus and complex pathogenesis of disease. None of the models offers an ideal system for the complex study of environmental exposure, genetic risk, and prevention strategies. In fact, different model systems may be required to answer different specific research questions about the pathogenesis of BE and EAC. Given the high mortality associated with EAC and the fact that current screening strategies miss most cases of EAC, advances in basic and translational science related to esophageal injury, repair, and carcinogenesis are clearly needed. This review describes several of the existing and potential model systems for BE and EAC with their benefits and disadvantages.

On the origin of the rising incidence of esophageal adenocarcinoma and prediction of future trends

2001 ◽  
Vol 120 (5) ◽  
pp. A30-A30
Author(s):  
J HELM ◽  
J BARTHEL ◽  
D COPPOLA ◽  
P LAZARUS ◽  
S LUTHER ◽  
...  
Keyword(s):  
Esophageal Adenocarcinoma ◽  
Future Trends ◽  
Rising Incidence

Risk factors for esophageal adenocarcinoma: A case-control study

2001 ◽  
Vol 120 (5) ◽  
pp. A442-A442
Author(s):  
B AVIDAN ◽  
A SONNENBERG ◽  
T SCHNELL ◽  
G CHEJFEC ◽  
A METZ ◽  
...  
Keyword(s):  
Risk Factors ◽  
Esophageal Adenocarcinoma ◽  
Case Control Study ◽  
Case Control ◽  
Control Study

Esophageal Adenocarcinoma with Enteroblastic Differentiation Arising in Ectopic Gastric Mucosa in the Cervical Esophagus: a Case Report and Literature Review

2017 ◽  
Vol 26 (2) ◽  
pp. 193-197 ◽  
Author(s):  
Ryosuke Gushima ◽  
Rei Narita ◽  
Takashi Shono ◽  
Hideaki Naoe ◽  
Takashi Yao ◽  
...  
Keyword(s):  
Gastric Mucosa ◽  
Esophageal Adenocarcinoma ◽  
Histopathological Examination ◽  
Narrow Band Imaging ◽  
Carbohydrate Antigen ◽  
Endoscopic Examination ◽  
Ectopic Gastric Mucosa ◽  
Tubular Adenocarcinoma ◽  
Positron Emission ◽  
Elevated Lesion

Background: Adenocarcinoma with enteroblastic differentiation is a subtype of alpha-fetoprotein (AFP) producing adenocarcinoma. This type of tumor is associated with a poor prognosis and is prone to metastasize. Esophageal adenocarcinoma with enteroblastic differentiation is extremely rare.Case presentation: The patient was a 65-year-old woman who was referred to our hospital with dysphagia. Endoscopic examination revealed an elevated lesion 20mm in diameter at 17cm from the upper incisors. Endoscopic submucosa dissection (ESD) was performed and histopathological examination revealed tubular adenocarcinoma composed of cuboidal cells with clear cell cytoplasm. Immunohistochemical stain was diffusely positive for Sall-like protein 4 (SALL4) and weakly positive for AFP and glypican 3. From this result, we diagnosed esophageal adenocarcinoma with enteroblastic differentiation. The patient is still alive without recurrence of cancer 40 months after ESD.Conclusion: To our knowledge, this is the first report to undergo ESD for esophageal adenocarcinoma with enteroblastic differentiation arising from ectopic gastric mucosa in the esophagus.Abbreviations: AFP: alfa-fetoprotein; CA19-9: carbohydrate antigen 19-9; CEA: carcinoembryonic antigen; ESD: endoscopic submucosal dissection; EUS: endoscopic ultrasound; FDG-PET: [18F] fluorodeoxyglucose positron emission tomography; ME: magnifying endoscopy; NBI: narrow band imaging; SALL 4: Sall-like protein 4; SCC: squamous cell carcinoma antigen.

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