Ethanol effects on naloxone-induced stimulation of the hypothalamic-pituitary system in healthy human subjects

2004 ◽  
Vol 112 (08) ◽  
Author(s):  
U Zimmermann ◽  
B Steffin ◽  
K Spring ◽  
M Uhr ◽  
S O'Connor ◽  
...  
Keyword(s):  
Human Subjects ◽  
Healthy Human ◽  
Healthy Human Subjects ◽  
Stimulation Of

scholarly journals Facial Vibrotactile Stimulation Activates the Parasympathetic Nervous System: Study of Salivary Secretion, Heart Rate, Pupillary Reflex, and Functional Near-Infrared Spectroscopy Activity

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Hisao Hiraba ◽  
Motoharu Inoue ◽  
Kanako Gora ◽  
Takako Sato ◽  
Satoshi Nishimura ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Infrared Spectroscopy ◽  
Near Infrared ◽  
Human Subjects ◽  
Vibrotactile Stimulation ◽  
Functional Near Infrared Spectroscopy ◽  
Healthy Human ◽  
Healthy Human Subjects ◽  
Stimulation Of

We previously found that the greatest salivation response in healthy human subjects is produced by facial vibrotactile stimulation of 89 Hz frequency with 1.9 μm amplitude (89 Hz-S), as reported by Hiraba et al. (2012, 20011, and 2008). We assessed relationships between the blood flow to brain via functional near-infrared spectroscopy (fNIRS) in the frontal cortex and autonomic parameters. We used the heart rate (HRV: heart rate variability analysis in RR intervals), pupil reflex, and salivation as parameters, but the interrelation between each parameter and fNIRS measures remains unknown. We were to investigate the relationship in response to established paradigms using simultaneously each parameter-fNIRS recording in healthy human subjects. Analysis of fNIRS was examined by a comparison of various values between before and after various stimuli (89 Hz-S, 114 Hz-S, listen to classic music, and “Ahh” vocalization). We confirmed that vibrotactile stimulation (89 Hz) of the parotid glands led to the greatest salivation, greatest increase in heart rate variability, and the most constricted pupils. Furthermore, there were almost no detectable differences between fNIRS during 89 Hz-S and fNIRS during listening to classical music of fans. Thus, vibrotactile stimulation of 89 Hz seems to evoke parasympathetic activity.

Electrical Stimulation of Somatic Afferent Nerves in the Foot Increases Bladder Capacity in Healthy Human Subjects

2014 ◽  
Vol 191 (4) ◽  
pp. 1009-1013 ◽  
Author(s):  
Mang L. Chen ◽  
Christopher J. Chermansky ◽  
Bing Shen ◽  
James R. Roppolo ◽  
William C. de Groat ◽  
...  
Keyword(s):  
Electrical Stimulation ◽  
Human Subjects ◽  
Bladder Capacity ◽  
Healthy Human ◽  
Afferent Nerves ◽  
Healthy Human Subjects ◽  
Stimulation Of

CLINICAL STUDIES OF "BIG ACTH": ITS PHYSICO-CHEMICAL CHARACTERISTICS

1978 ◽  
Vol 89 (2) ◽  
pp. 221-231 ◽  
Author(s):  
Yukio Yamada ◽  
Seiki Ito ◽  
Masahiro Miyashita ◽  
Kenzo Kaneko ◽  
Toru Watanabe ◽  
...  
Keyword(s):  
Human Subjects ◽  
Gel Filtration ◽  
Disc Electrophoresis ◽  
Plasma Samples ◽  
Acth Secretion ◽  
Healthy Human ◽  
Physico Chemical ◽  
Healthy Human Subjects ◽  
Pituitary Glands ◽  
Stimulation Of

ABSTRACT The big ACTH fractions available from human plasma and pituitary glands and from porcine pituitary glands were physico-chemically characterized by gel filtration, disc electrophoresis and isoelectric separation. In the case of healthy human subjects, big ACTH fractions were isolated by gel filtration from plasma samples taken during states of acute ACTH hypersecretion such as the lysine-8-vasopressin, insulin or metopyrone tests though none of these fractions were isolated from plasma sampled under normal conditions. Even with no stimulation of ACTH secretion, patients with Cushing's disease gave plasma samples that contained an isolable big ACTH fraction, but such a fraction was hardly isolated from plasma taken from patient with Addison's disease. Both human pituitaries and porcine pituitaries contained an isolable big ACTH fraction. By a gel filtration analysis the molecular weight of the big ACTH was estimated to be higher than 20 000. Disc electrophoresis with an acrylamide gel indicated that big ACTH is strongly basic while small ACTH is more acidic than pH 8.3. Isoelectric separation revealed that the isoelectric point of human big ACTH is higher than pH 10.0 while that of small ACTH is about pH 6.8.

Comparison of human vocal cord movements during isocapnic hypoxia and hypercapnia

1982 ◽  
Vol 53 (1) ◽  
pp. 81-86 ◽  
Author(s):  
S. J. England ◽  
D. Bartlett ◽  
S. L. Knuth
Keyword(s):  
Vocal Cord ◽  
Human Subjects ◽  
Healthy Human ◽  
Peripheral Chemoreceptors ◽  
Airflow Resistance ◽  
Air Breathing ◽  
Healthy Human Subjects ◽  
Laryngeal Resistance ◽  
Stimulation Of

Respiratory vocal cord movements were analyzed in healthy human subjects during air breathing and in isocapnic hypoxia and hypercapnia. In the majority of experiments, expiratory glottic narrowing was substantially greater during hypoxia than during hypercapnia. Because ventilations were carefully matched under these two conditions, it is concluded that hypoxic stimulation of peripheral chemoreceptors favors expiratory glottic narrowing and leads to a relatively high laryngeal airflow resistance. In contrast, hypercapnia is accompanied by low expiratory laryngeal resistance. Similar rates of expiratory airflow with these two stimuli must be achieved by different balances of the factors that determine this flow.

Chronic stress decreases circulating endocannabinoid 2-arachidonoylglycerol in healthy human subjects

2015 ◽  
Author(s):  
Buqing Yi ◽  
Igor Nichiporuk ◽  
Matthias Feuerecker ◽  
Gustav Schelling ◽  
Alexander Chouker
Keyword(s):  
Chronic Stress ◽  
Human Subjects ◽  
Healthy Human ◽  
Healthy Human Subjects

scholarly journals Acacia Gum Is Well Tolerated While Increasing Satiety and Lowering Peak Blood Glucose Response in Healthy Human Subjects

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 618
Author(s):  
Riley Larson ◽  
Courtney Nelson ◽  
Renee Korczak ◽  
Holly Willis ◽  
Jennifer Erickson ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Human Subjects ◽  
Area Under The Curve ◽  
Soluble Fiber ◽  
Healthy Human ◽  
Glucose Response ◽  
Blood Glucose Response ◽  
Acacia Gum ◽  
Fiber Treatment ◽  
Healthy Human Subjects

Acacia gum (AG) is a non-viscous soluble fiber that is easily incorporated into beverages and foods. To determine its physiological effects in healthy human subjects, we fed 0, 20, and 40 g of acacia gum in orange juice along with a bagel and cream cheese after a 12 h fast and compared satiety, glycemic response, gastrointestinal tolerance, and food intake among treatments. Subjects (n = 48) reported less hunger and greater fullness at 15 min (p = 0.019 and 0.003, respectively) and 240 min (p = 0.036 and 0.05, respectively) after breakfast with the 40 g fiber treatment. They also reported being more satisfied at 15 min (p = 0.011) and less hungry with the 40 g fiber treatment at 30 min (p = 0.012). Subjects reported more bloating, flatulence, and GI rumbling on the 40 g fiber treatment compared to control, although values for GI tolerance were all low with AG treatment. No significant differences were found in area under the curve (AUC) or change from baseline for blood glucose response, although actual blood glucose with 20 g fiber at 30 min was significantly less than control. Individuals varied greatly in their postprandial glucose response to all treatments. AG improves satiety response and may lower peak glucose response at certain timepoints, and it is well tolerated in healthy human subjects. AG can be added to beverages and foods in doses that can help meet fiber recommendations.

Diaphragmatic Fatigue after Exercise in Healthy Human Subjects

1993 ◽  
Vol 148 (6_pt_1) ◽  
pp. 1571-1575 ◽  
Author(s):  
M. Jeffery Mador ◽  
Ulysses J. Magalang ◽  
Angel Rodis ◽  
Thomas J. Kufel
Keyword(s):  
Human Subjects ◽  
Healthy Human ◽  
Healthy Human Subjects ◽  
Diaphragmatic Fatigue
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