Niedrige Elastase–1-Werte im Stuhl bei Typ 1-Diabetikern: kein (sicherer) Hinweis auf eine exokrine Pankreasinsuffizienz

2004 ◽  
Vol 42 (08) ◽  
Author(s):  
PG Lankisch ◽  
JU Hahn ◽  
S Bochnig ◽  
H König ◽  
B Sporleder ◽  
...  
Keyword(s):  
Elastase 1 ◽  
Exokrine Pankreasinsuffizienz

Assessment of pancreatic exocrine function in preterms by measurement of fecal elastase 1

2001 ◽  
Vol 120 (5) ◽  
pp. A214-A214
Author(s):  
M VENTRUCCI ◽  
V PAOLETTI ◽  
L CORVAGLIA ◽  
M CAPRETTI ◽  
M MIDDONNO ◽  
...  
Keyword(s):  
Pancreatic Exocrine Function ◽  
Exocrine Function ◽  
Fecal Elastase ◽  
Elastase 1 ◽  
Pancreatic Exocrine

A radioimmunoassay for pancreatic elastase 1: use of 1 conjugate as both standard and tracer to eliminate the influence of anti-elastase 1 autoantibodies

1993 ◽  
Vol 218 (1) ◽  
pp. 17-27 ◽  
Author(s):  
Hidehisa Asada ◽  
Kazunori Shibata ◽  
Kiyohisa Uchida ◽  
Yoshifumi Takeyama ◽  
Yoichi Saitoh ◽  
...  
Keyword(s):  
Pancreatic Elastase ◽  
Elastase 1 ◽  
Pancreatic Elastase 1

scholarly journals Does Pancreatic Elastase-1 in Stools Predict Steatorrhea in Type 1 Diabetes?

Diabetes Care ◽  
2006 ◽  
Vol 29 (3) ◽  
pp. 719-721 ◽  
Author(s):  
F. Cavalot ◽  
K. Bonomo ◽  
E. Fiora ◽  
E. Bacillo ◽  
P. Salacone ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Pancreatic Elastase ◽  
Elastase 1 ◽  
Pancreatic Elastase 1

scholarly journals Detection of human elastase isoforms by the ScheBo Pancreatic Elastase 1 Test

2017 ◽  
Vol 312 (6) ◽  
pp. G606-G614 ◽  
Author(s):  
Anna Zsófia Tóth ◽  
András Szabó ◽  
Eszter Hegyi ◽  
Péter Hegyi ◽  
Miklós Sahin-Tóth
Keyword(s):  
Test Performance ◽  
Genetic Variants ◽  
Molecular Targets ◽  
Exocrine Function ◽  
Clinical Test ◽  
Critical Determinant ◽  
Pancreatic Elastase ◽  
Elastase 1 ◽  
Common Genetic Variants ◽  
Pancreatic Elastase 1

Determination of fecal pancreatic elastase content by ELISA is a reliable, noninvasive clinical test for assessing exocrine pancreatic function. Despite the widespread use of commercial tests, their exact molecular targets remain poorly characterized. This study was undertaken to clarify which human pancreatic elastase isoforms are detected by the ScheBo Pancreatic Elastase 1 Stool Test and whether naturally occurring genetic variants influence the performance of this test. Using recombinantly expressed and purified human pancreatic proteinases, we found that the test specifically measured chymotrypsin-like elastases (CELA) 3A and 3B (CELA3A and CELA3B), while CELA2A was not detected. Inactive proelastases, active elastases, and autolyzed forms were detected with identical efficiency. CELA3B elicited approximately four times higher ELISA signal than CELA3A, and we identified Glu154in CELA3B as the critical determinant of detection. Common genetic variants of CELA3A and CELA3B had no effect on test performance, with the exception of the CELA3B variant W79R, which increased detection by 1.4-fold. Finally, none of the human trypsin and chymotrypsin isoforms were detected. We conclude that the ScheBo Pancreatic Elastase 1 Stool Test is specific for human CELA3A and CELA3B, with most of the ELISA signal attributable to CELA3B.NEW & NOTEWORTHY The ScheBo Pancreatic Elastase 1 Stool Test is widely used to assess pancreatic exocrine function, yet its molecular targets have been poorly defined. We demonstrate that, among the human pancreatic proteinases, the test measures the elastase isoform CELA3B and, to a lesser extent, CELA3A. Genetic variants of the human CELA3 isoforms have no significant effect on test performance.

Establishing the blood reference interval of pancreatic elastase‐1: A prospective study

2021 ◽  
Author(s):  
Su‐Fen Chi ◽  
Chia‐Yeh Lai ◽  
Wei‐Ting Dong ◽  
Jiunn‐Min Wang ◽  
Ya‐Yu Wang ◽  
...  
Keyword(s):  
Prospective Study ◽  
Reference Interval ◽  
Pancreatic Elastase ◽  
Elastase 1 ◽  
A Prospective Study ◽  
Pancreatic Elastase 1

Su1255 Fecal Elastase-1 in Patients With Suspected or Confirmed Chronic Pancreatitis and Its Relation to MRI and Secretin-MRCP Findings

2012 ◽  
Vol 142 (5) ◽  
pp. S-462 ◽  
Author(s):  
Yazan Abdalla ◽  
Nimah Jamaluddin ◽  
Sean M. Burns ◽  
Samer Alkaade
Keyword(s):  
Chronic Pancreatitis ◽  
Fecal Elastase ◽  
Elastase 1

scholarly journals Overlapping Specificity of Duplicated Human Pancreatic Elastase 3 Isoforms and Archetypal Porcine Elastase 1 Provides Clues to Evolution of Digestive Enzymes

2017 ◽  
Vol 292 (7) ◽  
pp. 2690-2702 ◽  
Author(s):  
Eszter Boros ◽  
András Szabó ◽  
Katalin Zboray ◽  
Dávid Héja ◽  
Gábor Pál ◽  
...  
Keyword(s):  
Digestive Enzymes ◽  
Pancreatic Elastase ◽  
Elastase 1

Urinary Elastase 1 in Chronic Pancreatic Disease

Enzyme ◽  
1989 ◽  
Vol 42 (2) ◽  
pp. 80-86 ◽  
Author(s):  
C. Fabris ◽  
D. Basso ◽  
L. Benini ◽  
T. Meggiato ◽  
G. Del Favero ◽  
...  
Keyword(s):  
Pancreatic Disease ◽  
Elastase 1

Positionspapier: Exokrine Pankreasinsuffizienz und Diabetes mellitus

2012 ◽  
Vol 124 (S2) ◽  
pp. 100-103 ◽  
Author(s):  
Raimund Weitgasser ◽  
Heidemarie Abrahamian ◽  
Martin Clodi ◽  
Werner Fortunat ◽  
Heinz Hammer
Keyword(s):  
Diabetes Mellitus ◽  
Exokrine Pankreasinsuffizienz

Diagnostic and prognostic value of serum elastase 1 in acute pancreatitis

1986 ◽  
Vol 64 (22) ◽  
pp. 1186-1191 ◽  
Author(s):  
M. Büchler ◽  
P. Malfertheiner ◽  
W. Uhl ◽  
H. G. Beger
Keyword(s):  
Acute Pancreatitis ◽  
Prognostic Value ◽  
Elastase 1 ◽  
Diagnostic And Prognostic Value
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