Construction And Characterization of a Conditionally Active Construct of The Insulin-Regulated Forkhead Transcription Factor FKHR

2002 ◽  
Vol 110 (06) ◽  
pp. 304-309 ◽  
Author(s):  
Andreas Barthel ◽  
Hans-Martin Orth ◽  
Klaus-Dieter Krüger ◽  
Dieter Schmoll ◽  
Hans-Georg Joost
Keyword(s):  
Transcription Factor ◽  
Forkhead Transcription Factor

Evolutionary conservation of redundancy between a diverged pair of forkhead transcription factor homologues

Development ◽  
2000 ◽  
Vol 127 (22) ◽  
pp. 4825-4835 ◽  
Author(s):  
L. Molin ◽  
A. Mounsey ◽  
S. Aslam ◽  
P. Bauer ◽  
J. Young ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Expression Patterns ◽  
Evolutionary Conservation ◽  
Early Embryo ◽  
Genetic Redundancy ◽  
Evolutionary Time ◽  
Forkhead Transcription Factor ◽  
C Elegans ◽  
Transitory Effect

The Caenorhabditis elegans gene pes-1 encodes a transcription factor of the forkhead family and is expressed in specific cells of the early embryo. Despite these observations suggesting pes-1 to have an important regulatory role in embryogenesis, inactivation of pes-1 caused no apparent phenotype. This lack of phenotype is a consequence of genetic redundancy. Whereas a weak, transitory effect was observed upon disruption of just T14G12.4 (renamed fkh-2) gene function, simultaneous disruption of the activity of both fkh-2 and pes-1 resulted in a penetrant lethal phenotype. Sequence comparison suggests these two forkhead genes are not closely related and the functional association of fkh-2 and pes-1 was only explored because of the similarity of their expression patterns. Conservation of the fkh-2/pes-1 genetic redundancy between C. elegans and the related species C. briggsae was demonstrated. Interestingly the redundancy in C. briggsae is not as complete as in C. elegans and this could be explained by alterations of pes-1 specific to the C. briggsae ancestry. With overlapping function retained on an evolutionary time-scale, genetic redundancy may be extensive and expression pattern data could, as here, have a crucial role in characterization of developmental processes.

Characterization of intracellular translocation of Forkhead transcription factor O (FoxO) members induced by NGF in PC12 cells

2011 ◽  
Vol 498 (1) ◽  
pp. 31-36 ◽  
Author(s):  
Qiang Wen ◽  
Xiaolu Duan ◽  
Rifang Liao ◽  
Peter Little ◽  
Guoquan Gao ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Pc12 Cells ◽  
Forkhead Transcription Factor ◽  
Intracellular Translocation

scholarly journals Mating Type in Chlamydomonas Is Specified by mid, the Minus-Dominance Gene

Genetics ◽  
1997 ◽  
Vol 146 (3) ◽  
pp. 859-869 ◽  
Author(s):  
Patrick J Ferris ◽  
Ursula W Goodenough
Keyword(s):  
Transcription Factor ◽  
Mating Type ◽  
Codon Bias ◽  
Leucine Zipper ◽  
Laboratory Strain ◽  
Leucine Zipper Motif ◽  
Type Locus ◽  
Diploid Cells ◽  
Necessary And Sufficient

Diploid cells of Chlamydomonas reinhardtii that are heterozygous at the mating-type locus (mt  +/mt  –) differentiate as minus gametes, a phenomenon known as minus dominance. We report the cloning and characterization of a gene that is necessary and sufficient to exert this minus dominance over the plus differentiation program. The gene, called mid, is located in the rearranged (R) domain of the mt  – locus, and has duplicated and transposed to an autosome in a laboratory strain. The imp11 mt  – mutant, which differentiates as a fusion-incompetent plus gamete, carries a point mutation in mid. Like the fus1 gene in the mt  + locus, mid displays low codon bias compared with other nuclear genes. The mid sequence carries a putative leucine zipper motif, suggesting that it functions as a transcription factor to switch on the minus program and switch off the plus program of gametic differentiation. This is the first sex-determination gene to be characterized in a green organism.

Characterization of a transcription factor SlNAC7 gene from Suaeda liaotungensis and its role in stress tolerance

2021 ◽  
Author(s):  
Hong-Fei Wang ◽  
Hong-Yan Shan ◽  
He Shi ◽  
Dan-Dan Wu ◽  
Tong-Tong Li ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Stress Tolerance

scholarly journals Functional characterization of a new grapevine MYB transcription factor and regulation of proanthocyanidin biosynthesis in grapes

2014 ◽  
Vol 65 (15) ◽  
pp. 4433-4449 ◽  
Author(s):  
Kazuya Koyama ◽  
Mineyo Numata ◽  
Ikuko Nakajima ◽  
Nami Goto-Yamamoto ◽  
Hideo Matsumura ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Functional Characterization ◽  
Myb Transcription Factor

Biochemical and genetic characterization of the porcine Prophet of Pit-1 pituitary transcription factor

2000 ◽  
Vol 168 (1-2) ◽  
pp. 77-87 ◽  
Author(s):  
Kyle W. Sloop ◽  
Amy McCutchan Schiller ◽  
Timothy P.L. Smith ◽  
John R. Blanton ◽  
Gary A. Rohrer ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Genetic Characterization
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