Direct Conversion of Esters to Hydroxyamides on Solid Support - a Key Step en route to Bisoxazoline Ligands

Synlett ◽  
2002 ◽  
Vol 2002 (02) ◽  
pp. 0247-0250
Author(s):  
Avi Weissberg ◽  
Moshe Portnoy
Keyword(s):  
Direct Conversion ◽  
Solid Support

scholarly journals A Novel, One-Step Palladium and Phenylsilane Activated Amidation from Allyl Ester on Solid Support

2008 ◽  
Vol 2008 ◽  
pp. 1-4
Author(s):  
Zheming Ruan ◽  
Katy Van Kirk ◽  
Christopher B. Cooper ◽  
R. Michael Lawrence
Keyword(s):  
Carboxylic Acid ◽  
Solid Phase ◽  
Direct Conversion ◽  
Solid Support ◽  
Phase Array ◽  
Reaction Conditions ◽  
Allyl Ester ◽  
One Step ◽  
Allyl Esters

The direct conversion of solid-supported carboxylic acid allyl esters to carboxamides through the use of phenylsilane and catalytic Pd under mild reaction conditions is reported. The use of this methodology for the generation of a 48 compound solid-phase array is described herein.

scholarly journals Direct palladium-mediated on-resin disulfide formation from Allocam protected peptides

2017 ◽  
Vol 15 (14) ◽  
pp. 2914-2918 ◽  
Author(s):  
Thilini D. Kondasinghe ◽  
Hasina Y. Saraha ◽  
Samantha B. Odeesho ◽  
Jennifer L. Stockdill
Keyword(s):  
Convenient Method ◽  
Direct Conversion ◽  
Solid Support ◽  
Disulfide Formation ◽  
Protected Peptides

We present a mild, convenient method for direct conversion of Allocam protected peptides to disulfide-containing protected peptides on solid support.

Use of the Magnetostatic Analogue In Electromagnetic Lens Engineering

1970 ◽  
Vol 28 ◽  
pp. 360-361
Author(s):  
John W. Coleman
Keyword(s):  
Boundary Conditions ◽  
High Performance ◽  
Force Fields ◽  
Optical Design ◽  
Direct Conversion ◽  
Design Engineering ◽  
Design Data ◽  
Scalar Potentials ◽  
Geometric Elements ◽  
At Will

In the design engineering of high performance electromagnetic lenses, the direct conversion of electron optical design data into drawings for reliable hardware is oftentimes difficult, especially in terms of how to mount parts to each other, how to tolerance dimensions, and how to specify finishes. An answer to this is in the use of magnetostatic analytics, corresponding to boundary conditions for the optical design. With such models, the magnetostatic force on a test pole along the axis may be examined, and in this way one may obtain priority listings for holding dimensions, relieving stresses, etc..The development of magnetostatic models most easily proceeds from the derivation of scalar potentials of separate geometric elements. These potentials can then be conbined at will because of the superposition characteristic of conservative force fields.

Ketones from Nickel-Catalyzed Decarboxylative, Non-Symmetric Cross-Electrophile Coupling of Carboxylic Acid Esters

2019 ◽  
Author(s):  
Jiang Wang ◽  
Brian P. Cary ◽  
Peyton Beyer ◽  
Samuel H. Gellman ◽  
Daniel Weix
Keyword(s):  
Carboxylic Acid ◽  
Solid Support ◽  
Reaction Conditions ◽  
Decarboxylative Coupling ◽  
New Strategy ◽  
The Cross ◽  
Acyl Donors ◽  
Acid Esters

A new strategy for the synthesis of ketones is presented based upon the decarboxylative coupling of N-hydroxyphthalimide (NHP) esters with S-2-pyridyl thioesters. The reactions are selective for the cross-coupled product because NHP esters act as radical donors and the thioesters act as acyl donors. The reaction conditions are general and mild, with over 40 examples presented, including larger fragments and the 20-mer peptide Exendin(9-39) on solid support.

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