Teriparatid – Das molekulare und klinische Profil bei der Therapie der Osteoporose

2019 ◽  
Vol 28 (01) ◽  
pp. 21-27
Author(s):  
Franz Jakob ◽  
Sigrid Müller-Deubert ◽  
Regina Ebert
Keyword(s):  
Real Life ◽  
Mechanische Belastung

ZusammenfassungPTH und PTHrP fördern situationsabhängig Knochenformation, -umbau und -abbau. Sie binden an den PTH Rezeptor Typ 1 (PTH1R) auf Osteoblasten, Osteozyten und T-Zellen und vermitteln Genregulation. Kurze Pulse wirken anabol, chronische Stimulation wirkt stark katabol. Teriparatid ist von PTH abgeleitet (Aminosäuren 1–34) und induziert Knochenformation, die durch mechanische Belastung auch an instabilen Stellen verstärkt wird. Klinische Endpunkte sind Zunahme an Knochenmasse und -struktur und deutliche Reduktion der Frakturrate der Wirbelkörper und – mit geringerer Effizienz – der non-vertebralen Frakturen. Die Wirkung ist in einem umfangreichen Studienprogramm in randomisierten kontrollierten und „Real-Life“-Studien evidenzbasiert belegt. Teriparatid wirkt bei Frauen und Männern, unter Glukokortikoid-Therapie und nach Bisphosphonat-Vorbehandlung. Es kann nur einmalig über 24 Monate verabreicht werden, nachfolgende Gabe von Antiresorptiva verbessert den Outcome. Gesundheitspolitische Vorgaben beschränken seine Anwendung in Deutschland auf die Situation neuer Frakturen unter Antiresorptiva. Teriparatid ist sicher, hat ein sehr gutes Nebenwirkungsprofil und ist das erste Beispiel einer Regenerativen Therapie in der Osteologie.

A peek in the micro-sized world: a review of design principles, engineering tools, and applications of engineered microbial community

2020 ◽  
Vol 48 (2) ◽  
pp. 399-409
Author(s):  
Baizhen Gao ◽  
Rushant Sabnis ◽  
Tommaso Costantini ◽  
Robert Jinkerson ◽  
Qing Sun
Keyword(s):  
Microbial Community ◽  
Microbial Communities ◽  
Environmental Remediation ◽  
Real Life ◽  
Design Principles ◽  
Microbial Interactions ◽  
Potential Applications ◽  
New Gene ◽  
Global Biogeochemical Cycles ◽  
Synthetic Microbial Communities

Microbial communities drive diverse processes that impact nearly everything on this planet, from global biogeochemical cycles to human health. Harnessing the power of these microorganisms could provide solutions to many of the challenges that face society. However, naturally occurring microbial communities are not optimized for anthropogenic use. An emerging area of research is focusing on engineering synthetic microbial communities to carry out predefined functions. Microbial community engineers are applying design principles like top-down and bottom-up approaches to create synthetic microbial communities having a myriad of real-life applications in health care, disease prevention, and environmental remediation. Multiple genetic engineering tools and delivery approaches can be used to ‘knock-in' new gene functions into microbial communities. A systematic study of the microbial interactions, community assembling principles, and engineering tools are necessary for us to understand the microbial community and to better utilize them. Continued analysis and effort are required to further the current and potential applications of synthetic microbial communities.

The Speech-Language Pathologist in the Public Schools: Preparation for Real Life Practices From the Perspective of a Speech-Language Pathology Program Coordinator

2010 ◽  
Vol 11 (2) ◽  
pp. 60-65
Author(s):  
Francine Wenhardt
Keyword(s):  
Public Schools ◽  
School Setting ◽  
Real Life ◽  
Effective School ◽  
Program Coordinator ◽  
Educational Preparation ◽  
The Public ◽  
Speech Language Pathologist ◽  
New Graduate ◽  
Language Pathology

Abstract The speech-language pathologist (SLP) working in the public schools has a wide variety of tasks. Educational preparation is not all that is needed to be an effective school-based SLP. As a SLP currently working in the capacity of a program coordinator, the author describes the skills required to fulfill the job requirements and responsibilities of the SLP in the school setting and advises the new graduate regarding the interview process and beginning a career in the public schools.

541 Tolerability of CHARM-ADDED candesartan in “real-life” patients with advanced chronic heart failure

2006 ◽  
Vol 5 (1) ◽  
pp. 119-119
Author(s):  
M MACDONALD ◽  
N HAWKINS ◽  
M SHAW ◽  
J MCMURRAY ◽  
H DARGIE ◽  
...  
Keyword(s):  
Heart Failure ◽  
Chronic Heart Failure ◽  
Real Life

Neuropsychology in the Real World

2014 ◽  
Vol 25 (4) ◽  
pp. 233-238 ◽  
Author(s):  
Martin Peper ◽  
Simone N. Loeffler
Keyword(s):  
Neuropsychological Assessment ◽  
Real World ◽  
Ecological Validity ◽  
Real Life ◽  
Emotional States ◽  
Context Sensitive ◽  
Traditional Assessment ◽  
Life Data ◽  
Real Life Data ◽  
Assessment And Treatment

Current ambulatory technologies are highly relevant for neuropsychological assessment and treatment as they provide a gateway to real life data. Ambulatory assessment of cognitive complaints, skills and emotional states in natural contexts provides information that has a greater ecological validity than traditional assessment approaches. This issue presents an overview of current technological and methodological innovations, opportunities, problems and limitations of these methods designed for the context-sensitive measurement of cognitive, emotional and behavioral function. The usefulness of selected ambulatory approaches is demonstrated and their relevance for an ecologically valid neuropsychology is highlighted.

On the Individual

1999 ◽  
Vol 4 (4) ◽  
pp. 205-218 ◽  
Author(s):  
David Magnusson
Keyword(s):  
School Psychologist ◽  
Real Life ◽  
Psychological Research ◽  
Developmental Research ◽  
Future Directions ◽  
The 1950S ◽  
The Individual ◽  
Over Time

A description of two cases from my time as a school psychologist in the middle of the 1950s forms the background to the following question: Has anything important happened since then in psychological research to help us to a better understanding of how and why individuals think, feel, act, and react as they do in real life and how they develop over time? The studies serve as a background for some general propositions about the nature of the phenomena that concerns us in developmental research, for a summary description of the developments in psychological research over the last 40 years as I see them, and for some suggestions about future directions.

Intelligence and Personality

2020 ◽  
Vol 41 (3) ◽  
pp. 124-132
Author(s):  
Marc-André Bédard ◽  
Yann Le Corff
Keyword(s):  
Personality Traits ◽  
Big Five ◽  
Real Life ◽  
Big Five Personality Traits ◽  
Original Study ◽  
Life Assessment ◽  
Big Five Personality ◽  
Verbal Intelligence ◽  
Nonverbal Intelligence ◽  
French Canadian

Abstract. This replication and extension of DeYoung, Quilty, Peterson, and Gray’s (2014) study aimed to assess the unique variance of each of the 10 aspects of the Big Five personality traits ( DeYoung, Quilty, & Peterson, 2007 ) associated with intelligence and its dimensions. Personality aspects and intelligence were assessed in a sample of French-Canadian adults from real-life assessment settings ( n = 213). Results showed that the Intellect aspect was independently associated with g, verbal, and nonverbal intelligence while its counterpart Openness was independently related to verbal intelligence only, thus replicating the results of the original study. Independent associations were also found between Withdrawal, Industriousness and Assertiveness aspects and verbal intelligence, as well as between Withdrawal and Politeness aspects and nonverbal intelligence. Possible explanations for these associations are discussed.

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