Red blood cell fatty acid profile of chronic renal failure patients receiving maintenance haemodialysis treatment

2002 ◽  
Vol 67 (1) ◽  
pp. 13-18 ◽  
Author(s):  
A.M. Koorts ◽  
M. Viljoen ◽  
M.C. Kruger
1985 ◽  
Vol 13 (5) ◽  
pp. 1129-1135
Author(s):  
Kazuo MORI ◽  
Susumu YUKAWA ◽  
Akira HIBINO ◽  
Miyahiko SONOBE ◽  
Osamu NISHIKAWA ◽  
...  

Obesity ◽  
2020 ◽  
Vol 28 (8) ◽  
pp. 1456-1466 ◽  
Author(s):  
Pamela A. Nono Nankam ◽  
Amy E. Mendham ◽  
Paul J. Jaarsveld ◽  
Kevin Adams ◽  
Melony C. Fortuin‐de Smidt ◽  
...  

1997 ◽  
Vol 44 (1) ◽  
pp. 99-107 ◽  
Author(s):  
K Gwoździński ◽  
M Janicka ◽  
J Brzeszczyńska ◽  
M Luciak

The properties of red blood cell membranes in patients with chronic renal failure were investigated using electron paramagnetic resonance spectroscopy. Using spin traps, 5,5-dimethylpirroline-1 oxide and N-tert-butyl-alpha-phenylnitrone, we found generation of hydroxyl radicals in the blood of patients with chronic renal failure after 20 min of regular hemodialysis. The physical state of membrane proteins and membrane osmotic fragility and reductive properties of red blood cells were studied. The increase in the relative correlation time of 4-(2-iodoacetamido)-2,2,6,6-tetramethylpiperidine-1 oxyl indicates the immobilization of membrane protein molecules in erythrocytes of chronic renal failure patients. The decrease in membrane protein mobility was observed in whole blood incubated with tert-butylhydroperoxide, regardless of the presence of iron. We found that the addition of ferrous ions did not aggravate profound changes in membrane proteins induced with tert-butylhydroperoxide. We also demonstrated higher osmotic fragility of erythrocytes in the patients with renal failure as compared to normal subjects. These alterations in membrane structure of red blood cells in hemodialysed patients suggest that hydroxyl radicals generated during hemodialysis can play an important role in the oxidative mechanism of erythrocyte damage.


2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Mark McIntosh ◽  
Robert H Lerman ◽  
Colleen J Kalynych ◽  
Clare Vukich ◽  
Maria Luz Fernandez ◽  
...  

PLoS ONE ◽  
2020 ◽  
Vol 15 (12) ◽  
pp. e0244129
Author(s):  
Simone Lanini ◽  
Chiara Montaldo ◽  
Emanuele Nicastri ◽  
Francesco Vairo ◽  
Chiara Agrati ◽  
...  

Background Detailed temporal analyses of complete (full) blood count (CBC) parameters, their evolution and relationship to patient age, gender, co-morbidities and management outcomes in survivors and non-survivors with COVID-19 disease, could identify prognostic clinical biomarkers. Methods From 29 January 2020 until 28 March 2020, we performed a longitudinal cohort study of COVID-19 inpatients at the Italian National Institute for Infectious Diseases, Rome, Italy. 9 CBC parameters were studied as continuous variables [neutrophils, lymphocytes, monocytes, platelets, mean platelet volume, red blood cell count, haemoglobin concentration, mean red blood cell volume and red blood cell distribution width (RDW %)]. Model-based punctual estimates, as average of all patients’ values, and differences between survivors and non-survivors, overall, and by co-morbidities, at specific times after symptoms, with relative 95% CI and P-values, were obtained by marginal prediction and ANOVA- style joint tests. All analyses were carried out by STATA 15 statistical package. Main findings 379 COVID-19 patients [273 (72% were male; mean age was 61.67 (SD 15.60)] were enrolled and 1,805 measures per parameter were analysed. Neutrophils’ counts were on average significantly higher in non-survivors than in survivors (P<0.001) and lymphocytes were on average higher in survivors (P<0.001). These differences were time dependent. Average platelets’ counts (P<0.001) and median platelets’ volume (P<0.001) were significantly different in survivors and non-survivors. The differences were time dependent and consistent with acute inflammation followed either by recovery or by death. Anaemia with anisocytosis was observed in the later phase of COVID-19 disease in non-survivors only. Mortality was significantly higher in patients with diabetes (OR = 3.28; 95%CI 1.51–7.13; p = 0.005), obesity (OR = 3.89; 95%CI 1.51–10.04; p = 0.010), chronic renal failure (OR = 9.23; 95%CI 3.49–24.36; p = 0.001), COPD (OR = 2.47; 95% IC 1.13–5.43; p = 0.033), cardiovascular diseases (OR = 4.46; 95%CI 2.25–8.86; p = 0.001), and those >60 years (OR = 4.21; 95%CI 1.82–9.77; p = 0.001). Age (OR = 2.59; 95%CI 1.04–6.45; p = 0.042), obesity (OR = 5.13; 95%CI 1.81–14.50; p = 0.002), renal chronic failure (OR = 5.20; 95%CI 1.80–14.97; p = 0.002) and cardiovascular diseases (OR 2.79; 95%CI 1.29–6.03; p = 0.009) were independently associated with poor clinical outcome at 30 days after symptoms’ onset. Interpretation Increased neutrophil counts, reduced lymphocyte counts, increased median platelet volume and anaemia with anisocytosis, are poor prognostic indicators for COVID19, after adjusting for the confounding effect of obesity, chronic renal failure, COPD, cardiovascular diseases and age >60 years.


Nephron ◽  
1998 ◽  
Vol 80 (1) ◽  
pp. 76-78 ◽  
Author(s):  
A. Oliveras ◽  
J. Aubia ◽  
H. Cao ◽  
J.M. Puig ◽  
F. Barbosa ◽  
...  

2004 ◽  
Vol 44 (4) ◽  
pp. 715-719 ◽  
Author(s):  
Joseph Ly ◽  
Rosa Marticorena ◽  
Sandra Donnelly

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