High caffeine consumption was associated with an increased risk of detrusor instability and urge incontinence

2001 ◽  
Vol 3 (2) ◽  
pp. 97-98
Author(s):  
Dudley Robinson ◽  
Linda Cardozo
Keyword(s):  
Urge Incontinence ◽  
Detrusor Instability ◽  
Caffeine Consumption ◽  
Increased Risk

scholarly journals Maternal caffeine intake during pregnancy and childhood growth and overweight: results from a large Norwegian prospective observational cohort study

BMJ Open ◽  
2018 ◽  
Vol 8 (3) ◽  
pp. e018895 ◽  
Author(s):  
Eleni Papadopoulou ◽  
Jérémie Botton ◽  
Anne-Lise Brantsæter ◽  
Margaretha Haugen ◽  
Jan Alexander ◽  
...  
Keyword(s):  
Cohort Study ◽  
Weight Gain ◽  
Task Force ◽  
Individual Growth ◽  
Caffeine Intake ◽  
Supporting Evidence ◽  
Caffeine Consumption ◽  
Childhood Growth ◽  
Increased Risk ◽  
Very High

ObjectivesTo study the association between maternal caffeine intake during pregnancy and the child’s weight gain and overweight risk up to 8 years.DesignProspective nationwide pregnancy cohort.SettingThe Norwegian Mother and Child Cohort Study.ParticipantsA total of 50 943 mothers recruited from 2002 to 2008 and their children, after singleton pregnancies, with information about average caffeine intake assessed at mid-pregnancy.Outcome measureChild’s body size information at 11 age points from 6 weeks to 8 years. We defined excess growth in infancy as a WHO weight gain z-score of >0.67 from birth to age 1 year, and overweight according to the International Obesity Task Force. We used a growth model to assess individual growth trajectories.ResultsCompared with pregnant women with low caffeine intake (<50 mg/day, 46%), women with average (50–199 mg/day, 44%), high (≥200–299 mg/day, 7%) and very high (≥300 mg/day, 3%) caffeine intakes had an increased risk of their child experiencing excess growth in infancy, after adjustment for confounders (OR=1.15, 95% CI 1.09 to 1.22, OR=1.30, 95% CI 1.16 to 1.45, OR=1.66, 95% CI 1.42 to 1.93, respectively). In utero exposure to any caffeine was associated with higher risk of overweight at age 3 years and 5 years, while the association persisted at 8 years, only for very high exposures. Any caffeine intake was associated with increased body mass index from infancy to childhood. Children prenatally exposed to caffeine intake >200 mg/day had consistently higher weight. Very high caffeine exposures were associated with higher weight gain velocity from infancy to age 8 years.ConclusionAny caffeine consumption during pregnancy is associated with a higher risk of excess infant growth and of childhood overweight, mainly at preschool ages. Maternal caffeine intake may modify the overall weight growth trajectory of the child from birth to 8 years. This study adds supporting evidence for the current advice to reduce caffeine intake during pregnancy.

scholarly journals Stress inconthence and detrusor instability/urge incontinence

1985 ◽  
Vol 4 (4) ◽  
pp. 313-316 ◽  
Author(s):  
E. J. McGuire ◽  
J. A. Savastano
Keyword(s):  
Urge Incontinence ◽  
Detrusor Instability

scholarly journals ASSOCIATION BETWEEN GLAUCOMA PREVALENCE AND SUPPLEMENTATION WITH CALCIUM, IRON AND CAFFEINE

2020 ◽  
pp. 49-51
Author(s):  
Sarika Gaur ◽  
Ramesh Kumar ◽  
Kuldeep Kuldeep ◽  
Ananya Singh
Keyword(s):  
Cross Sectional Study ◽  
Sectional Study ◽  
Caffeine Consumption ◽  
Cross Sectional ◽  
Increased Risk ◽  
Health Related ◽  
Period Data ◽  
Calcium Iron ◽  
Prospective Longitudinal ◽  
The Relationship

PURPOSE. To investigate the relationship between supplementary consumption of the oxidants calcium and iron and caffeine and the prevalence of glaucoma. METHODS. This cross-sectional study included 3833 participants 40 years of age, who reported a presence or absence of glaucoma. Participants were interviewed regarding the use of dietary supplements and antacids during the preceding 30-day period. Data pertaining to the supplementary intake of calcium, iron and caffeine was aggregated and divided into quintiles. Information regarding the presence or absence of glaucoma and demographics, comorbidities, and health-related behavior was obtained via interview. RESULTS. Participants who consumed 800 mg/d of supplementary calcium or 18 mg/d of supplementary iron had significantly higher odds of having been diagnosed with glaucoma than did those who had not consumed supplementary calcium or iron, after adjustment for potential confounders. Concurrent consumption of both calcium and iron above these levels was associated with still greater odds of having been diagnosed with glaucoma. Compared with participants whose cumulatively updated total caffeine consumption was <125 mg/day, participants who consumed ≥500 mg/day had a trend toward increased risk of glaucoma. CONCLUSIONS. These results suggest that there may be a threshold intake of iron, calcium and caffeine above which there is an increased risk of development of glaucoma. Prospective longitudinal studies are needed, to assess whether oxidant intake is a risk factor for development and progression of glaucoma.

scholarly journals The Relation between Caffeine Consumption and Endometriosis: An Updated Systematic Review and Meta-Analysis

Nutrients ◽  
2021 ◽  
Vol 13 (10) ◽  
pp. 3457
Author(s):  
Konstantinos S. Kechagias ◽  
Konstantinos Katsikas Triantafyllidis ◽  
Margarita Kyriakidou ◽  
Panagiotis Giannos ◽  
Ilkka Kalliala ◽  
...  
Keyword(s):  
Systematic Review ◽  
Meta Analysis ◽  
Statistical Significance ◽  
Caffeine Intake ◽  
Contributing Factors ◽  
Case Control Studies ◽  
Caffeine Consumption ◽  
Increased Risk ◽  
Probable Role

While the contributing factors leading to endometriosis remain unclear, its clinical heterogeneity suggests a multifactorial causal background. Amongst others, caffeine has been studied extensively during the last decade as a putative contributing factor. In this systematic review and meta-analysis, we provide an overview/critical appraisal of studies that report on the association between caffeine consumption and the presence of endometriosis. In our search strategy, we screened PubMed and Scopus for human studies examining the above association. The main outcome was the relative risk of endometriosis in caffeine users versus women consuming little or no caffeine (<100 mg/day). Subgroup analyses were conducted for different levels of caffeine intake: high (>300 mg/day) or moderate (100–300 mg/day). Ten studies were included in the meta-analysis (five cohort and five case-control studies). No statistically significant association was observed between overall caffeine consumption and risk for endometriosis (RR 1.12, 95% confidence interval (CI) 0.97–1.28, I2 = 70%) when compared to little or no (<100 mg/day) caffeine intake. When stratified according to level of consumption, high intake was associated with increased risk of endometriosis (RR 1.30, 95%CI 1.04–1.63, I2 = 56%), whereas moderate intake did not reach nominal statistical significance (RR 1.18, 95%CI 0.99–1.40, I2 = 37%). In conclusion, caffeine consumption does not appear to be associated with increased risk for endometriosis. However, further research is needed to elucidate the potential dose-dependent link between caffeine and endometriosis or the probable role of caffeine intake as a measurement of other unidentified biases.

Trigger Factors for Spontaneous Intracerebral Hemorrhage: A Case-Crossover Study

Stroke ◽  
2021 ◽  
Author(s):  
Ellis S. van Etten ◽  
Kanishk Kaushik ◽  
Wilmar M.T. Jolink ◽  
Emma A. Koemans ◽  
Merel S. Ekker ◽  
...  
Keyword(s):  
Intracerebral Hemorrhage ◽  
Coffee Consumption ◽  
Spontaneous Intracerebral Hemorrhage ◽  
Caffeine Consumption ◽  
Vigorous Exercise ◽  
Trigger Factors ◽  
Case Crossover ◽  
Increased Risk ◽  
Potential Trigger ◽  
Vessel Rupture

Background and Purpose: Whether certain activities can trigger spontaneous intracerebral hemorrhage (ICH) remains unknown. Insights into factors that trigger vessel rupture resulting in ICH improves knowledge on the pathophysiology of ICH. We assessed potential trigger factors and their risk for ICH onset. Methods: We included consecutive patients diagnosed with ICH between July 1, 2013, and December 31, 2019. We interviewed patients on their exposure to 12 potential trigger factors (eg, Valsalva maneuvers) in the (hazard) period soon before onset of ICH and their normal exposure to these trigger factors in the year before the ICH. We used the case-crossover design to calculate relative risks (RR) for potential trigger factors. Results: We interviewed 149 patients (mean age 64, 66% male) with ICH. Sixty-seven (45%) had a lobar hemorrhage, 60 (40%) had a deep hemorrhage, 19 (13%) had a cerebellar hemorrhage, and 3 (2%) had an intraventricular hemorrhage. For ICH in general, there was an increased risk within an hour after caffeine consumption (RR=2.5 [95% CI=1.8–3.6]), within an hour after coffee consumption alone (RR=4.8 [95% CI=3.3–6.9]), within an hour after lifting >25 kg (RR=6.6 [95% CI=2.2–19.9]), within an hour after minor head trauma (RR=10.1 [95% CI=1.7–60.2]), within an hour after sexual activity (RR=30.4 [95% CI=16.8–55.0]), within an hour after straining for defecation (RR=37.6 [95% CI=22.4–63.4]), and within an hour after vigorous exercise (RR=21.8 [95% CI=12.6–37.8]). Within 24 hours after flu-like disease or fever, the risk for ICH was also increased (RR=50.7 [95% CI=27.1–95.1]). Within an hour after Valsalva maneuvers, the RR for deep ICH was 3.5 (95% CI=1.7–6.9) and for lobar ICH the RR was 2.0 (95% CI=0.9–4.2). Conclusions: We identified one infection and several blood pressure related trigger factors for ICH onset, providing new insights into the pathophysiology of vessel rupture resulting in ICH.

scholarly journals Maternal caffeine consumption and pregnancy outcomes: a narrative review with implications for advice to mothers and mothers-to-be

2020 ◽  
pp. bmjebm-2020-111432 ◽  
Author(s):  
Jack E. James
Keyword(s):  
Birth Weight ◽  
Preterm Birth ◽  
Pregnancy Outcomes ◽  
Observational Studies ◽  
Overweight And Obesity ◽  
Caffeine Consumption ◽  
Childhood Overweight And Obesity ◽  
Increased Risk ◽  
Health Advice ◽  
Meta Analyses

ObjectivesCaffeine is a habit-forming substance consumed daily by the majority of pregnant women. Accordingly, it is important that women receive sound evidence-based advice about potential caffeine-related harm. This narrative review examines evidence of association between maternal caffeine consumption and negative pregnancy outcomes, and assesses whether current health advice concerning maternal caffeine consumption is soundly based.MethodsDatabase searches using terms linking caffeine and caffeinated beverages to pregnancy outcomes identified 1261 English language peer-reviewed articles. Screening yielded a total of 48 original observational studies and meta-analyses of maternal caffeine consumption published in the past two decades. The articles reported results for one or more of six major categories of negative pregnancy outcomes: miscarriage, stillbirth, low birth weight and/or small for gestational age, preterm birth, childhood acute leukaemia, and childhood overweight and obesity.ResultsOf 42 separate sets of findings reported in 37 observational studies, 32 indicated significantly increased caffeine-related risk and 10 suggested no or inconclusive associations. Caffeine-related increased risk was reported with moderate to high levels of consistency for all pregnancy outcomes except preterm birth. Of 11 studies reporting 17 meta-analyses, there was unanimity among 14 analyses in finding maternal caffeine consumption to be associated with increased risk for the four outcome categories of miscarriage, stillbirth, low birth weight and/or small for gestational age, and childhood acute leukaemia. The three remaining meta-analyses were also unanimous in reporting absence of a reliable association between maternal caffeine consumption and preterm birth. No meta-analyses were identified for childhood overweight and obesity, although four of five original observational studies reported significant associations linking maternal caffeine consumption to that outcome category.ConclusionsThe substantial majority finding from observational studies and meta-analyses is that maternal caffeine consumption is reliably associated with major negative pregnancy outcomes. Reported findings were robust to threats from potential confounding and misclassification. Among both observational studies and meta-analyses, there were frequent reports of significant dose–response associations suggestive of causation, and frequent reports of no threshold of consumption below which associations were absent. Consequently, current evidence does not support health advice that assumes 'moderate' caffeine consumption during pregnancy is safe. On the contrary, the cumulative scientific evidence supports pregnant women and women contemplating pregnancy being advised to avoid caffeine.

scholarly journals Caffeine Consumption Habits of New Zealand Tertiary Students

Nutrients ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 1493
Author(s):  
Saskia Stachyshyn ◽  
Ajmol Ali ◽  
Carol Wham ◽  
Tayla Knightbridge-Eager ◽  
Kay Rutherfurd-Markwick
Keyword(s):  
New Zealand ◽  
Caffeine Intake ◽  
Caffeine Consumption ◽  
Increased Risk ◽  
Health Initiatives ◽  
Adverse Effect Level ◽  
Cognitive Benefits ◽  
Level 3 ◽  
Effect Level ◽  
Consumption Habits

Adverse effects associated with excessive caffeine consumption combined with increasing numbers and availability of caffeine-containing products are causes for concern. Tertiary students may be at increased risk of consuming excessive amounts of caffeine due to seeking caffeinated products with well-known wakefulness effects and cognitive benefits. This study explored caffeine consumption habits of New Zealand tertiary students (317; ≥16-years) using a previously validated caffeine consumption habits (CaffCo) questionnaire. Most (99.1%) regularly consumed caffeinated products, especially chocolate, coffee and tea, with coffee, tea and energy drinks contributing most to total caffeine intake. Median estimated caffeine intake was 146.73 mg·day−1, or 2.25 mg·kgbw−1·day−1. Maximum and minimum intakes were 1988.14 mg·day−1 (23.51 mg·kgbw−1·day−1) and 0.07 mg·day−1 (0.02 mg·kgbw−1·day−1), respectively. One-third (34.4%) of caffeine consumers ingested caffeine above the adverse effect level (3 mg·kgbw−1·day−1) and 14.3% above the safe limit (400 mg·day−1). Most caffeine consumers (84.7%), reported experiencing at least one ‘adverse symptom’ post-caffeine consumption, of which 25.7% reported effects leading to distress or negatively impacting their life. Experiencing ‘adverse symptoms’ did not, however, curtail consumption in the majority of symptomatic participants (~77%). Public health initiatives directed at tertiary students may be important to reduce potential caffeine-related harm.

scholarly journals Examining Cardiovascular Symptoms in Adults with Chronic Insomnia

2021 ◽  
Author(s):  
Suzanne Fredericks ◽  
Souraya Sidani ◽  
Joyal Miranda ◽  
Mary Fox
Keyword(s):  
Physical Activity ◽  
Cardiovascular Diseases ◽  
Sleep Apnoea ◽  
Chronic Insomnia ◽  
Anxiety And Depression ◽  
Physical Factors ◽  
Caffeine Consumption ◽  
Cross Sectional ◽  
Physiological Factors ◽  
Increased Risk

Chronic insomnia is characterised by difficulty initiating and maintaining sleep, waking up too early, non-restorative sleep, and daytime impairment, experienced for 6 or more weeks (American Academy of Sleep Medicine, 2005). Its prevalence is estimated at 50.0% of the general population worldwide (Irish et al, 2015; Kredlow et al, 2015). The experience of chronic insomnia is associated with an increased risk for chronic diseases, cardiovascular diseases in particular (King et al, 2008; Tsunoda et al, 2015). Evidence from cross-sectional and longitudinal studies demonstrates a significant relationship between insomnia and risk of cardiovascular diseases, after controlling for sleep disorders that are physiological in nature (e.g. sleep apnoea) and for other risks of cardiovascular diseases, such as smoking, low levels of physical activity, and alcohol and caffeine consumption (Foley et al, 2004; Phillips et al, 2007; Hoevenaar-Blom et al, 2011). This evidence suggests that non-physiological factors contribute to the risk of cardiovascular diseases in persons with chronic insomnia. Stress, manifested as anxiety and depression, is often experienced by persons with chronic insomnia (Specchio et al, 2004; Taylor et al, 2007), and those with anxiety report cardiovascular symptoms such as chest pain and dyspnea (Ketterer et al, 2008). There is limited research exploring the contribution of psychological (i.e. insomnia, anxiety, and depression) or physical factors (smoking, physical activity, and alcohol and caffeine consumption) to the experience of cardiovascular symptoms (which are indicative of cardiovascular diseases) among adults with chronic insomnia.

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