A combined stress hormone infusion decreases in vivo protein synthesis in human T lymphocytes in healthy volunteers

Metabolism ◽  
2001 ◽  
Vol 50 (11) ◽  
pp. 1308-1314 ◽  
Author(s):  
Anna Januszkiewicz ◽  
Pia Ess[eacute]n ◽  
Margaret A. McNurlan ◽  
Olle Ringd[eacute]n ◽  
Peter J. Garlick ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
T Lymphocytes ◽  
Healthy Volunteers ◽  
Stress Hormone ◽  
Combined Stress ◽  
Human T Lymphocytes ◽  
In Vivo Protein Synthesis

Determination of in vivo protein synthesis in human T lymphocytes

2001 ◽  
Vol 20 (2) ◽  
pp. 181-182 ◽  
Author(s):  
A. JANUSZKIEWICZ ◽  
P. ESSÉN ◽  
M.A. McNURLAN ◽  
O. RINGDÉN ◽  
P.J. GARLICK ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
T Lymphocytes ◽  
Human T Lymphocytes ◽  
In Vivo Protein Synthesis

scholarly journals Response of in vivo protein synthesis in T lymphocytes and leucocytes to an endotoxin challenge in healthy volunteers

2002 ◽  
Vol 130 (2) ◽  
pp. 263-270 ◽  
Author(s):  
A. JANUSZKIEWICZ ◽  
K. LORÉ ◽  
P. ESSÉN ◽  
B. ANDERSSON ◽  
M. A. MCNURLAN ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
T Lymphocytes ◽  
Healthy Volunteers ◽  
Endotoxin Challenge ◽  
In Vivo Protein Synthesis

In vivo protein synthesis of circulating human T lymphocytes does not respond to a cortisol challenge within 24 h

2000 ◽  
Vol 44 (2) ◽  
pp. 202-209 ◽  
Author(s):  
A. Januszkiewicz ◽  
P. Essén ◽  
M. A. Mcnurlan ◽  
O. Ringdén ◽  
J. Wernerman ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
T Lymphocytes ◽  
Human T Lymphocytes ◽  
In Vivo Protein Synthesis

Determination of in vivo protein synthesis in human palatine tonsil

2005 ◽  
Vol 108 (2) ◽  
pp. 179-184 ◽  
Author(s):  
Anna JANUSZKIEWICZ ◽  
Maria KLAUDE ◽  
Karin LORÉ ◽  
Jan ANDERSSON ◽  
Olle RINGDÉN ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
T Lymphocytes ◽  
Immune Cells ◽  
Mononuclear Cells ◽  
Palatine Tonsil ◽  
Synthesis Rate ◽  
Protein Synthesis Rate ◽  
Palatine Tonsils ◽  
In Vivo Protein Synthesis

The palatine tonsils are constantly exposed to ingested or inhaled antigens which, in turn, lead to a permanent activation of tonsillar immune cells, even in a basic physiological state. The aim of the present study was to investigate if the immunological activation of the human palatine tonsil is reflected by a high metabolic activity, as determined by in vivo measurement of protein synthesis. The protein synthesis rate of the tonsil was also compared with that of the circulating T-lymphocytes, the total blood mononuclear cells and the whole population of blood leucocytes. Phenotypic characterization of immune-competent cells in tonsil tissue and blood was performed by flow cytometry. Pinch tonsil biopsies were taken after induction of anaesthesia in healthy adult patients (n=12) scheduled for ear surgery, uvulopalatopharyngoplasty or nose surgery. Protein synthesis was quantitatively determined during a 90-min period by a flooding-dose technique. The in vivo protein synthesis rate in the palatine tonsils was 22.8±5.7%/24 h (mean±S.D.), whereas protein synthesis in the circulating T-lymphocytes was 10.7±3.4%/24 h, in mononuclear cells was 10.8±2.8%/24 h and in leucocytes was 3.2±1.2%/24 h. CD3+ lymphocytes were the most abundant cell population in the tonsil. The in vivo protein synthesis rate in human tonsils was higher compared with the circulating immune cells. This high metabolic rate may reflect the permanent immunological activity present in human tonsils, although cell phenotypes and activity markers do not explain the differences.

O.06 Stress hormone infusion decreases protein synthesis of circulating human T lymphocytes

1998 ◽  
Vol 17 ◽  
pp. 2 ◽  
Author(s):  
A. Januszkiewicz ◽  
P. Essdn ◽  
M.A. McNurlan ◽  
P.J. Garlick ◽  
O. Ringdén ◽  
...  
Keyword(s):  
Protein Synthesis ◽  
T Lymphocytes ◽  
Stress Hormone ◽  
Human T Lymphocytes

Ricin inhibition of in vivo protein-synthesis in castor beans

1984 ◽  
Vol 36 (1) ◽  
pp. 1-5 ◽  
Author(s):  
Suzanne M. Harley ◽  
Harry Beevers
Keyword(s):  
Protein Synthesis ◽  
In Vivo Protein Synthesis
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