Beta-cell function and visceral fat in lactating women with a history of gestational diabetes

Metabolism ◽  
2001 ◽  
Vol 50 (6) ◽  
pp. 715-719 ◽  
Author(s):  
Ruth M. McManus ◽  
Ian Cunningham ◽  
Annette Watson ◽  
Lynda Harker ◽  
Diane T. Finegood
Keyword(s):  
Gestational Diabetes ◽  
Beta Cell ◽  
Visceral Fat ◽  
Beta Cell Function ◽  
Cell Function ◽  
Lactating Women ◽  
History Of

scholarly journals Longitudinal changes in insulin sensitivity and beta cell function between women with and without a history of gestational diabetes mellitus

Diabetologia ◽  
2013 ◽  
Vol 56 (12) ◽  
pp. 2753-2760 ◽  
Author(s):  
Anny H. Xiang ◽  
Miwa Takayanagi ◽  
Mary Helen Black ◽  
Enrique Trigo ◽  
Jean M. Lawrence ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Insulin Sensitivity ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function ◽  
Longitudinal Changes ◽  
History Of

scholarly journals Glucose Intolerance after a Recent History of Gestational Diabetes

2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Katrien Benhalima ◽  
Liesbeth Leuridan ◽  
Peggy Calewaert ◽  
Roland Devlieger ◽  
Johan Verhaeghe ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Gestational Diabetes ◽  
Beta Cell ◽  
Glucose Intolerance ◽  
Beta Cell Function ◽  
Cell Function ◽  
Screening Strategy ◽  
Recent History ◽  
Sensitivity Index ◽  
History Of

Aim. Our aim was to evaluate the uptake of our current screening strategy postpartum and the risk factors for glucose intolerance in women with a recent history of gestational diabetes (GDM).Methods. Retrospective analysis of files of women with a recent history of GDM diagnosed with the Carpenter and Coustan criteria from 01-01-2010 till 31-12-2013. Multivariable logistic regression was used to adjust for confounders.Results. Of all 231 women with a recent history of GDM, 21.4% (46) did not attend the scheduled postpartum OGTT. Of the women tested, 39.1% (66) had glucose intolerance and 5.3% (9) had diabetes. These women were more often overweight (39.7% versus 25.3%,P= 0.009), were more often treated with basal-bolus insulin injections (52.0% versus 17.4%,P= 0.032), and had a lower beta-cell function and lower insulin sensitivity, remaining significant after adjustment for age, BMI, and ethnicity (insulin secretion sensitivity index-2 (ISSI-2) in pregnancy 1.5 ± 0.5 versus 1.7 ± 0.4,P= 0.029; ISSI-2 postpartum 1.5 (1.2–1.9) versus 2.2 (1.8–2.6),P= 0.020; Matsuda index postpartum 3.8 (2.6–6.2) versus 6.0 (4.3–8.8),P= 0.021).Conclusion. Glucose intolerance is frequent in early postpartum and these women have a lower beta-cell function and lower insulin sensitivity. One fifth of women did not attend the scheduled OGTT postpartum.

scholarly journals Pancreatic Fat Is Associated With Metabolic Syndrome and Visceral Fat but Not Beta-Cell Function or Body Mass Index in Pediatric Obesity

Pancreas ◽  
2017 ◽  
Vol 46 (3) ◽  
pp. 358-365 ◽  
Author(s):  
Johan Staaf ◽  
Viktor Labmayr ◽  
Katharina Paulmichl ◽  
Hannes Manell ◽  
Jing Cen ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Body Mass Index ◽  
Beta Cell ◽  
Body Mass ◽  
Visceral Fat ◽  
Pediatric Obesity ◽  
Beta Cell Function ◽  
Cell Function ◽  
Pancreatic Fat

scholarly journals Investigation of the progress in the women with gestational diabetes mellitus postpartum

2021 ◽  
pp. 45-51
Author(s):  
Thi To Nhu Phan ◽  
Trung Vinh Hoang
Keyword(s):  
Diabetes Mellitus ◽  
Logistic Regression ◽  
Glucose Tolerance ◽  
Beta Cell ◽  
Glucose Intolerance ◽  
Beta Cell Function ◽  
Cell Function ◽  
Postpartum Women ◽  
Matsuda Index ◽  
History Of

Aims: Our aim was to evaluate the uptake of postpartum screening, the prevalence and the risk factors for glucose intolerance in women with a recent history of gestational diabetes mellitus (GDM). Methods: All women with a history of GDM are advised to undergo a 75g oral glucose tolerance test (OGTT) around 6 - 12 weeks postpartum. Indices of insulin sensitivity (the Matsuda index and the reciprocal of the homeostasis model assessment of insulin resistance, HOMA-IR) and an index of beta-cell function, the Insulin Secretion-Sensitivity Index-2 (ISSI-2) were calculated based on the OGTT postpartum. Multivariable logistic regression was used to some factors. Results: Of all women (135) who received an OGTT postpartum, 42.2% (57) had glucose intolerance (11.8% impaired fasting glucose, 24.4% impaired glucose tolerance and 6.0% both impaired fasting and impaired glucose tolerance) and 1.5% (2) had overt diabetes. Compared to women with a normal OGTT postpartum, women with glucose intolerance and diabetes were older (32.5 ± 4.3 vs. 30.8 ± 4.8 years, p = 0.049), were more often obese (34.5% vs. 17.3%, p = 0.023). In the multivariable logistic regression, an EM background [OR = 2.76 (1.15 - 6.62), p = 0.023] and the HbA1c level at the time of the OGTT in pregnancy [OR = 4.78 (1.19 - 19.20), p = 0.028] remained significant predictors for glucose intolerance postpartum. Women with glucose intolerance and diabetes postpartum had a similar insulin sensitivity [Matsuda index 0.656 (0.386 - 1.224) vs. 0.778 (0.532 - 1.067), p = 0.709; HOMA-IR 0.004 (0.002 - 0.009) vs. 0.064 (0.003 - 0.007), p = 0.384] but a lower beta-cell function compared to women with a normal OGTT postpartum, remaining significant after adjustment for confounders [ISSI-2 1.6 (1.2 - 2.1) vs. 1.9 (1.7 - 2.4), p = 0.002]. Conclusions: Glucose intolerance is very frequent in early postpartum in women with GDM these women have an impaired beta-cell function. Nearly one third of women did not attend the scheduled OGTT postpartum and these women have an adverse risk profile. More efforts are needed to engage and stimulate women with GDM to attend the postpartum OGTT.

scholarly journals Evaluation of Circulating Determinants of Beta-Cell Function in Women With and Without Gestational Diabetes

2016 ◽  
Vol 101 (7) ◽  
pp. 2683-2691 ◽  
Author(s):  
Ravi Retnakaran ◽  
Chang Ye ◽  
Caroline K. Kramer ◽  
Philip W. Connelly ◽  
Anthony J. Hanley ◽  
...  
Keyword(s):  
Gestational Diabetes ◽  
Beta Cell ◽  
Beta Cell Function ◽  
Cell Function

Metabolomic Characteristics of Fatty Pancreas

2019 ◽  
Vol 128 (12) ◽  
pp. 804-810 ◽  
Author(s):  
Benjamin Assad Jaghutriz ◽  
Róbert Wagner ◽  
Martin Heni ◽  
Rainer Lehmann ◽  
Jürgen Machann ◽  
...  
Keyword(s):  
Insulin Secretion ◽  
Beta Cell ◽  
Visceral Fat ◽  
Beta Cell Function ◽  
Cell Function ◽  
Fat Content ◽  
Pancreatic Fat ◽  
Total Body ◽  
Pancreatic Steatosis ◽  
Pancreatic Fat Content

Abstract Objective Pancreatic steatosis is associated with impaired beta cell function in patients with prediabetes. The pathomechanisms underlying this association still remain to be elucidated. Recent data show that adipocytes are situated within the pancreatic parenchyma and therefore give raise to hypothesize that pancreatic fat together with known and unknown metabolites such as hepatokines affect insulin secretion. Applying a targeted metabolomic approach we investigated possible circulating markers of pancreatic fat in order to better understand its role in the pathophysiology of impaired beta cell function. Methods We included 361 Caucasians, at increased risk of type 2 diabetes, from the Tübingen Family Study. All participants underwent a frequently sampled oral glucose tolerance test to assess insulin secretion and a magnetic resonance imaging to quantify pancreatic fat content, total body fat and visceral fat. Among the 152 subjects with prediabetes (IFG and/or IGT), two groups each with 20 individuals, having the lowest and highest pancreatic fat content were selected. The groups were matched for sex, age, BMI, total fat content, visceral fat content, liver fat content and insulin sensitivity. Metabolites were analyzed using the AbsoluteIDQ® p400 HR Kit by Biocrates. Results Pancreatic fat content of all 152 subjects with prediabetes was negatively associated with insulin secretion represented by AUCC-peptide 0–120/AUCGlucose 0–120 (p=0.04; β=− 3.24). Furthermore, pancreatic fat content was positively associated with BMI, total body and visceral fat (all p<0.005). Levels of aminoacids, biogenic amines and monosaccharides were similar between the groups with high/low pancreatic fat content (p>0.90). Also, levels of polar lipids such as lysophosphatidylcholines, phosphatidylcholines, sphingomyelins and ceramides did not differ significantly between the groups (p>0.90). Investigating the levels of neutral lipids such as aclycarnitines, diglycerides, triglycerides and cholesteryl esters also revealed no differences between the groups (p>0.90). Conclusion The amount of pancreatic fat is not associated with the metabolomic pattern in individuals with prediabetes. This might be due to the relatively low pancreatic fat content compared to the total amount of fat stored in other depots. The impact of pancreatic steatosis on insulin secretion might be mediated by paracrine effects which cannot be detected in the circulation.

scholarly journals Visceral fat resection in humans: Effect on insulin sensitivity, beta-cell function, adipokines, and inflammatory markers

Obesity ◽  
2013 ◽  
Vol 21 (3) ◽  
pp. E182-E189 ◽  
Author(s):  
Marcelo M. O. Lima ◽  
Jose C. Pareja ◽  
Sarah M. Alegre ◽  
Sylka R. Geloneze ◽  
Steven E. Kahn ◽  
...  
Keyword(s):  
Insulin Sensitivity ◽  
Beta Cell ◽  
Visceral Fat ◽  
Inflammatory Markers ◽  
Beta Cell Function ◽  
Cell Function
Sign in / Sign up

Export Citation Format

Share Document