Cerebral blood flow in nondemented elderly subjects with extensive deep white matter lesions on magnetic resonance imaging

2000 ◽  
Vol 9 (4) ◽  
pp. 172-175 ◽  
Author(s):  
Hiroshi Yao ◽  
Takefumi Yuzuriha ◽  
Kenji Fukuda ◽  
Takashi Matsumoto ◽  
Setsuro Ibayashi ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
Magnetic Resonance ◽  
White Matter Lesions ◽  
Elderly Subjects ◽  
Resonance Imaging ◽  
Deep White Matter

scholarly journals Reduction in cerebral blood flow in areas appearing as white matter hyperintensities on magnetic resonance imaging

2009 ◽  
Vol 172 (2) ◽  
pp. 117-120 ◽  
Author(s):  
Adam M. Brickman ◽  
Amir Zahra ◽  
Jordan Muraskin ◽  
Jason Steffener ◽  
Christopher M. Holland ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
Magnetic Resonance ◽  
White Matter Hyperintensities ◽  
Resonance Imaging

A Magnetic Resonance Imaging Study of White Matter Lesions in Depression and Alzheimer's Disease

1996 ◽  
Vol 168 (4) ◽  
pp. 477-485 ◽  
Author(s):  
John O'brien ◽  
Patricia Desmond ◽  
David Ames ◽  
Isaac Schweitzer ◽  
Susan Harrigan ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
White Matter ◽  
Magnetic Resonance ◽  
Imaging Study ◽  
White Matter Lesions ◽  
Elderly Subjects ◽  
Resonance Imaging ◽  
Mri Scans

BackgroundWhite matter changes, as revealed by magnetic resonance imaging (MRI), may occur in depression and Alzheimer's disease.MethodT2-weighted MRI scans were performed in 39 control subjects, 61 subjects with NINCDS/ADRDA Alzheimer's disease and 60 subjects with DSM–III–R major depression. Deep white matter lesions (DWML) and periventricular lesions (PVL) were rated on a standard 0–3 scale by two radiologists blind to clinical diagnosis.ResultsAfter controlling for differences in vascular risk factors and current blood pressure, DWML were significantly more common in depressed subjects and PVL in Alzheimer's disease subjects compared to controls. DWML were most common in those presenting in late life with their first ever depression and 50% of such subjects had severe (grade 3) DWML.ConclusionAn association between DWML and depression and PVL and Alzheimer's disease is supported. The increase with DWML that occurs with ageing may predispose some elderly subjects to depression.

scholarly journals Magnetic resonance imaging abnormalities in young euthymic patients with bipolar affective disorder

2006 ◽  
Vol 189 (1) ◽  
pp. 81-82 ◽  
Author(s):  
Selim M. El-Badri ◽  
David A. Cousins ◽  
Sean Parker ◽  
Heather C. Ashton ◽  
Victor L. McAllister ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Bipolar Disorder ◽  
White Matter ◽  
Magnetic Resonance ◽  
Temporal Lobe ◽  
Bipolar Affective Disorder ◽  
White Matter Lesions ◽  
Resonance Imaging ◽  
Deep White Matter ◽  
Mri Scans

SummaryTemporal lobe and limbic structures may be abnormal in bipolar disorder. T2-weighted magnetic resonance imaging (MRI) scans frequently show deep white matter lesions. MRI was performed on 50 young (19–39 years) euthymic patients with bipolar disorder and 26 controls. Mean temporal lobe volumes were reduced in patients (right, 9.42 cm3; left, 6.33 cm3) but this could not be ascribed to a specific structure. Deep white matter lesions were present in 5 patients but no controls raising questions of their aetiological significance.

scholarly journals Oxygen challenge magnetic resonance imaging in healthy human volunteers

2016 ◽  
Vol 37 (1) ◽  
pp. 366-376 ◽  
Author(s):  
Krishna A Dani ◽  
Fiona C Moreton ◽  
Celestine Santosh ◽  
Rosario Lopez ◽  
David Brennan ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
White Matter ◽  
Magnetic Resonance ◽  
Grey Matter ◽  
Statistical Significance ◽  
Resonance Imaging ◽  
Two Stage ◽  
Healthy Human

Oxygen challenge imaging involves transient hyperoxia applied during deoxyhaemoglobin sensitive (T2*-weighted) magnetic resonance imaging and has the potential to detect changes in brain oxygen extraction. In order to develop optimal practical protocols for oxygen challenge imaging, we investigated the influence of oxygen concentration, cerebral blood flow change, pattern of oxygen administration and field strength on T2*-weighted signal. Eight healthy volunteers underwent multi-parametric magnetic resonance imaging including oxygen challenge imaging and arterial spin labelling using two oxygen concentrations (target FiO2 of 100 and 60%) administered consecutively (two-stage challenge) at both 1.5T and 3T. There was a greater signal increase in grey matter compared to white matter during oxygen challenge (p < 0.002 at 3T, P < 0.0001 at 1.5T) and at FiO2 = 100% compared to FiO2 = 60% in grey matter at both field strengths (p < 0.02) and in white matter at 3T only (p = 0.0314). Differences in the magnitude of signal change between 1.5T and 3T did not reach statistical significance. Reduction of T2*-weighted signal to below baseline, after hyperoxia withdrawal, confounded interpretation of two-stage oxygen challenge imaging. Reductions in cerebral blood flow did not obscure the T2*-weighted signal increases. In conclusion, the optimal protocol for further study should utilise target FiO2 = 100% during a single oxygen challenge. Imaging at both 1.5T and 3T is clinically feasible.

A 10-year longitudinal study of deep white matter lesions on magnetic resonance imaging

2021 ◽  
Author(s):  
Aiko Tamura ◽  
Nagato Kuriyama ◽  
Kentaro Akazawa ◽  
Etsuko Ozaki ◽  
Isao Watanabe ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Longitudinal Study ◽  
White Matter ◽  
Magnetic Resonance ◽  
White Matter Lesions ◽  
Resonance Imaging ◽  
Deep White Matter

scholarly journals Combined Brain-Heart Magnetic Resonance Imaging in Autoimmune Rheumatic Disease Patients with Cardiac Symptoms: Hypothesis Generating Insights from a Cross-Sectional Study

2020 ◽  
Vol 9 (2) ◽  
pp. 447 ◽  
Author(s):  
George Markousis-Mavrogenis ◽  
Dimos D. Mitsikostas ◽  
Loukia Koutsogeorgopoulou ◽  
Theodoros Dimitroulas ◽  
Gikas Katsifis ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Logistic Regression ◽  
White Matter ◽  
Magnetic Resonance ◽  
Odds Ratio ◽  
White Matter Lesions ◽  
Brain Lesions ◽  
Resonance Imaging ◽  
Deep White Matter ◽  
Cardiac Symptoms

Background: Autoimmune rheumatic diseases (ARDs) may affect both the heart and the brain. However, little is known about the interaction between these organs in ARD patients. We asked whether brain lesions are more frequent in ARD patients with cardiac symptoms compared with non-ARD patients with cardiovascular disease (CVD). Methods: 57 ARD patients with mean age of 48 ± 13 years presenting with shortness of breath, chest pain, and/or palpitations, and 30 age-matched disease-controls with non-autoimmune CVD, were evaluated using combined brain–heart magnetic resonance imaging (MRI) in a 1.5T system. Results: 52 (91%) ARD patients and 16 (53%) controls had white matter hyperintensities (p < 0.001) in at least one brain area (subcortical/deep/periventricular white matter, basal ganglia, pons, brainstem, or mesial temporal lobe). Only the frequency and number of subcortical and deep white matter lesions were significantly greater in ARD patients (p < 0.001 and 0.014, respectively). ARD vs. control status was the only independent predictor of having any brain lesion. Specifically for deep white matter lesions, each increase in ECV independently predicted a higher number of lesions [odds ratio (95% confidence interval): 1.16 (1.01–1.33), p = 0.031] in ordered logistic regression. Penalized logistic regression selected only ARD vs. control status as the most important feature for predicting whether brain lesions were present on brain MRI (odds ratio: 5.46, marginal false discovery rate = 0.011). Conclusions: Subclinical brain involvement was highly prevalent in this cohort of ARD patients and was mostly independent of the severity of cardiac involvement. However, further research is required to determine the clinical relevance of these findings.

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