scholarly journals Age matters: collagen birefringence of superficial articular cartilage is increased in young guinea-pigs but decreased in older animals after identical physiological type of joint loading

2001 ◽  
Vol 9 (8) ◽  
pp. 694-701 ◽  
Author(s):  
M.M. Hyttinen ◽  
J.P.A. Arokoski ◽  
J.J. Parkkinen ◽  
M.J. Lammi ◽  
T. Lapveteläinen ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Guinea Pigs ◽  
Joint Loading ◽  
Physiological Type

Indentation stiffness of young canine knee articular cartilage—Influence of strenuous joint loading

1990 ◽  
Vol 23 (12) ◽  
pp. 1239-1246 ◽  
Author(s):  
J. Jurvelin ◽  
I. Kiviranta ◽  
A.-M. Säämänen ◽  
M. Tammi ◽  
H.J. Helminen
Keyword(s):  
Articular Cartilage ◽  
Joint Loading

Aging Changes in Ultrastructure and Enzymatic Activity of Articular Cartilage of Guinea Pigs

1970 ◽  
Vol 25 (3) ◽  
pp. 184-198 ◽  
Author(s):  
R. Silberberg ◽  
W. G. Stamp ◽  
P. A. Lesker ◽  
M. Hasler
Keyword(s):  
Articular Cartilage ◽  
Enzymatic Activity ◽  
Guinea Pigs

Functional in situ assessment of human articular cartilage using MRI: a whole-knee joint loading device

2017 ◽  
Vol 16 (6) ◽  
pp. 1971-1986 ◽  
Author(s):  
Sven Nebelung ◽  
Manuel Post ◽  
Stefan Raith ◽  
Horst Fischer ◽  
Matthias Knobe ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Knee Joint ◽  
Human Articular Cartilage ◽  
Joint Loading ◽  
Loading Device ◽  
In Situ Assessment ◽  
Knee Joint Loading

Effects of Joint Loading on Articular Cartilage Collagen Metabolism: Assay of Procollagen Prolyl 4-Hydroxylase and Galactosylhydroxylysyl Glucosyltransferase

1988 ◽  
Vol 17 (3) ◽  
pp. 199-206 ◽  
Author(s):  
Markku Tammi ◽  
Ilkka Kiviranta ◽  
Leena Peltonen ◽  
Jukka Jurvelin ◽  
Heikki J. Helminen
Keyword(s):  
Articular Cartilage ◽  
Collagen Metabolism ◽  
Joint Loading

Regulation of collagen synthesis and mRNA levels in articular cartilage of scorbutic guinea pigs

1986 ◽  
Vol 246 (1) ◽  
pp. 33-41 ◽  
Author(s):  
Robert G. Spanheimer ◽  
Timothy A. Bird ◽  
Beverly Peterkofsky
Keyword(s):  
Articular Cartilage ◽  
Guinea Pigs ◽  
Collagen Synthesis ◽  
Mrna Levels

scholarly journals Model predictions of increased knee joint loading in regions of thinner articular cartilage after patellar tendon adhesion

2011 ◽  
Vol 29 (8) ◽  
pp. 1168-1177 ◽  
Author(s):  
Justin W. Fernandez ◽  
Massoud Akbarshahi ◽  
Kay M. Crossley ◽  
Kevin B. Shelburne ◽  
Marcus G. Pandy
Keyword(s):  
Articular Cartilage ◽  
Knee Joint ◽  
Patellar Tendon ◽  
Joint Loading ◽  
Model Predictions ◽  
Knee Joint Loading

Regular joint loading in youth assists in the establishment and strengthening of the collagen network of articular cartilage and contributes to the prevention of osteoarthrosis later in life: a hypothesis

2000 ◽  
Vol 18 (5) ◽  
pp. 245-257 ◽  
Author(s):  
Heikki J. Helminen ◽  
Mika M. Hyttinen ◽  
Mikko J. Lammi ◽  
Jari P. A. Arokoski ◽  
Tuomo Lapveteläinen ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Joint Loading ◽  
Collagen Network

scholarly journals Rapamycin-induced hyperglycemia is associated with exacerbated age-related osteoarthritis

2021 ◽  
Vol 23 (1) ◽  
Author(s):  
Dennis M. Minton ◽  
Christian J. Elliehausen ◽  
Martin A. Javors ◽  
Kelly S. Santangello ◽  
Adam R. Konopka
Keyword(s):  
Body Weight ◽  
Articular Cartilage ◽  
Plasma Glucose ◽  
Guinea Pigs ◽  
Structural Damage ◽  
Control Diet ◽  
Lower Body ◽  
Mtor Inhibition ◽  
Age Related ◽  
Lower Body Weight

Abstract Background The objective of this study was to determine if mechanistic target of rapamycin (mTOR) inhibition with or without AMP-activated protein kinase (AMPK) activation can protect against primary, age-related OA. Design Dunkin-Hartley guinea pigs develop mild primary OA pathology by 5 months of age that progresses to moderate OA by 8 months of age. At 5 months, guinea pigs served as young control (n = 3) or were fed either a control diet (n = 8), a diet enriched with the mTOR-inhibitor rapamycin (Rap, 14 ppm, n = 8), or Rap with the AMPK-activator metformin (Rap+Met, 1000 ppm, n = 8) for 12 weeks. Knee joints were evaluated by OARSI scoring, micro-computed tomography, and immunohistochemistry. Glenohumeral articular cartilage was collected for western blotting. Results Rap- and Rap+Met-treated guinea pigs displayed lower body weight than control. Rap and Rap+Met inhibited articular cartilage mTORC1 but not mTORC2 signaling. Rap+Met, but not Rap alone, stimulated AMPK. Despite lower body weight and articular cartilage mTORC1 inhibition, Rap- and Rap+Met-treated guinea pigs had greater OA severity in the medial tibial plateau due to articular cartilage structural damage and/or proteoglycan loss. Rap and Rap+Met increased plasma glucose compared to control. Plasma glucose concentration was positively correlated with proteoglycan loss, suggesting hyperglycemic stress after Rap treatment was related to worsened OA. Conclusions This is the first study to show that Rap induced increase in plasma glucose was associated with greater OA severity. Further, articular cartilage mTORC1 inhibition and bodyweight reduction by dietary Rap and Rap+Met did not appear to protect against primary OA during the prevailing hyperglycemia.

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