Clinical evidence of distinct subgroups of astrocytic tumors defined by comparative genomic hybridization

2000 ◽  
Vol 31 (5) ◽  
pp. 608-614 ◽  
Author(s):  
Takafumi Nishizaki ◽  
Hisashi Kubota ◽  
Kei Harada ◽  
Katsumi Harada ◽  
Haruhide Ito ◽  
...  
Keyword(s):  
Comparative Genomic Hybridization ◽  
Clinical Evidence ◽  
Comparative Genomic ◽  
Astrocytic Tumors ◽  
Genomic Hybridization

Whole-genome analysis of human astrocytic tumors by comparative genomic hybridization

2000 ◽  
Vol 17 (1) ◽  
pp. 21-27 ◽  
Author(s):  
Motohiko Maruno ◽  
Hirotomo Ninomiya ◽  
A. K. M. Ghulam Muhammad ◽  
Masayuki Hirata ◽  
Amami Kato ◽  
...  
Keyword(s):  
Comparative Genomic Hybridization ◽  
Genome Analysis ◽  
Comparative Genomic ◽  
Whole Genome ◽  
Astrocytic Tumors ◽  
Genomic Hybridization ◽  
Whole Genome Analysis

Recurrent gain of chromosome arm 7q in low-grade astrocytic tumors studied by comparative genomic hybridization

1996 ◽  
Vol 15 (4) ◽  
pp. 199-205 ◽  
Author(s):  
Evelin Schröck ◽  
Collin Blume ◽  
Marie-Christine Meffert ◽  
Stanislas du Manoir ◽  
Wolf Bersch ◽  
...  
Keyword(s):  
Comparative Genomic Hybridization ◽  
Comparative Genomic ◽  
Low Grade ◽  
Astrocytic Tumors ◽  
Genomic Hybridization ◽  
Chromosome Arm

Chromosomal imbalances in primary oligodendroglial tumors and their recurrences: clues about malignant progression detected using comparative genomic hybridization

2002 ◽  
Vol 96 (3) ◽  
pp. 559-564 ◽  
Author(s):  
Judith W. M. Jeuken ◽  
Sandra H. E. Sprenger ◽  
Harry Vermeer ◽  
Arnoud C. Kappelle ◽  
Rudolf H. Boerman ◽  
...  
Keyword(s):  
Comparative Genomic Hybridization ◽  
Malignant Progression ◽  
Comparative Genomic ◽  
Astrocytic Tumors ◽  
Genomic Hybridization ◽  
Content Type ◽  
Chromosomal Imbalances ◽  
Oligodendroglial Tumors ◽  
Recurrent Tumors ◽  
Fine Print

Object. Despite the rapid increase in knowledge concerning the genetic basis of malignant progression in astrocytic tumors, progression of oligodendroglial tumors (including both pure oligodendrogliomas and mixed oligoastrocytomas) is still poorly understood. The aim of the present study is the elucidation of chromosomal imbalances involved in the progression of oligodendroglial tumors toward malignancy. Methods. Using comparative genomic hybridization (CGH) on snap-frozen tumor tissue, the tumor genomes of five primary oligodendroglial tumors and associated recurrent tumors were screened for chromosomal imbalances. This information was correlated with clinical data (including follow-up data) and histopathological malignancy grade. In all cases an increase in chromosomal imbalances was detected in the recurrent tumor, indicating genetic progression. In three of the five cases this correlated with malignant progression detected at the histopathological level. The results indicate that, similar to what occurs in astrocytic tumors, chromosomal imbalances harboring genes involved in the cell proliferation control mechanism at the G1-S border are involved in the progression of oligodendroglial tumors. Additionally, although gains of genetic material on chromosome 7 and losses on chromosome 10 are most frequently detected in the course of malignant progression of astrocytic tumors, either or both of these can also occur during malignant progression of typical oligodendroglial tumors that contain losses involving chromosome 1p and/or chromosome 19q. Conclusions. When performed on optimally preserved material from a small set of primary oligodendroglial tumors and associated recurrent tumors, CGH detects chromosomal aberrations that potentially play a mechanistic role in the malignant progression of these tumors.

566: Comparative Genomic Hybridization of Chemotherapy Survived Wilms' Tumor Cells

2004 ◽  
Vol 171 (4S) ◽  
pp. 150-151
Author(s):  
Thorsten Schlomm ◽  
Bastian Gunawan ◽  
Hans J. Schulten ◽  
Norbert Graf ◽  
Ivo Leuschner ◽  
...  
Keyword(s):  
Tumor Cells ◽  
Comparative Genomic Hybridization ◽  
Wilms Tumor ◽  
Comparative Genomic ◽  
Genomic Hybridization
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