scholarly journals Giant-cell granuloma: 2 case reports

2018 ◽  
Vol 24 (4) ◽  
pp. 182-186
Author(s):  
Samir Abdelqader ◽  
Nicolas Roche ◽  
Laurent Manfredi ◽  
Jean-François Papon ◽  
Louis Maman ◽  
...  
Keyword(s):  
Giant Cell ◽  
Kidney Failure ◽  
Case Reports ◽  
Osteolytic Lesion ◽  
Systemic Disease ◽  
Excisional Biopsy ◽  
Bone Lesions ◽  
Giant Cell Granuloma ◽  
First Case ◽  
Osteoclastic Resorption

Introduction: Giant-cell granuloma (GCG) is a benign tumor occurring almost exclusively in the jaws. These lesions remain rare but can sometime have an aggressive behavior. In this article, we will describe and follow two cases of GCG. Observations: The first case is a referred female patient, who presents a mandibular swelling. Its clinical and radiological aspects lead us to do a biopsy, with a histological result of GCG. The second case is a patient with a terminal kidney failure, referred for a buccal swelling in the upper left jaw. The cone-beam computed tomography X-ray shows a compartmentalized lesion with blurry limits. An excisional biopsy is performed and the histological diagnosis is a GCG. Discussion: Although the first patient suffers from no systemic disease, the second one presents a terminal kidney failure resulting in a chronic hyperparathyroidism. Hyperparathyroidism can activate osteoclastic resorption and create bone lesions such as brown tumors. Conclusion: The slow and asymptomatic growth of these lesions often result in a late diagnosis. It should be kept in mind as a differential diagnosis when dealing with an osteolytic lesion of the jaws with no clear etiology, especially if hyperparathyroidism or kidney failure is associated.

scholarly journals Angiomyolipoma of the Oral Cavity: A Rare Case Report

2019 ◽  
pp. 107-110
Author(s):  
Sara Amanpour ◽  
Mohammad Reza Zarei ◽  
Javad Faryabi ◽  
Ahmad Ahrari
Keyword(s):  
Oral Cavity ◽  
Giant Cell ◽  
Case Reports ◽  
Thick Wall ◽  
Giant Cell Granuloma ◽  
First Case ◽  
Peripheral Giant Cell Granuloma ◽  
Rare Case Report ◽  
Rare Benign Tumor ◽  
Local Trauma

Angiomyolipoma (AML) is a rare, benign tumor composed of thick-wall blood vessels, smooth muscle component and mature adispose tissue. Differentiation from other benign and malignant mesenchymal lesions of oral cavity depends on recognition of these three histologic components, and immunohistochemical (IHC) techniques are also helpful. This tumor arise from perivascular epithelioid cells (PEComas) and kidneys followed by liver are the main locations of this soft tissue tumor. AMLs are rarely found in oral cavity and few case reports of oral AML have been reported in the literature. We report the first case of concurrent occurrence of AML of the tongue and peripheral giant cell granuloma of the gingiva in a 59-year-old patient. Clinically it was presented as a painless nodular mass with a smooth surface on the dorsal of the tongue. Based on histopathologic features and IHC staining the diagnosis of oral AML was done. The other lesion was a small sessile mass in interdental papillae of the lower incisors and microscopic examination showed the histologic features of a peripheral giant cell granuloma. Concurrent occurrence of PGCG which is a reactive mucosal hyperplasia and AML in our patient, could show the probable role of local trauma in the pathogenesis of these lesions.

scholarly journals Clinical Management of a Peri-Implant Giant Cell Granuloma

2015 ◽  
Vol 2015 ◽  
pp. 1-7
Author(s):  
A. Pacifici ◽  
D. Carbone ◽  
R. Marini ◽  
G. L. Sfasciotti ◽  
L. Pacifici
Keyword(s):  
Giant Cell ◽  
Dental Implant ◽  
Correct Diagnosis ◽  
Excisional Biopsy ◽  
Giant Cell Granuloma ◽  
Peripheral Giant Cell Granuloma ◽  
Natural Teeth ◽  
Implant Therapy

Purpose. Implant therapy plays an important role in contemporary dentistry with high rates of long-term success. However, in recent years, the incidence of peri-implantitis and implant failures has significantly increased. The peripheral giant cell granuloma (PGCG) rarely occurs in peri-implant tissues and it is clinically comparable to the lesions associated with natural teeth. Therefore, the study of possible diseases associated with dental implants plays an important role in order to be able to diagnose and treat these conditions.Materials and Methods. This report described a 60-year-old Caucasian male who presented a reddish-purple pedunculated mass, of about 2 cm in diameter, associated with a dental implant and the adjacent natural tooth.Results. An excisional biopsy was performed and the dental implant was not removed. Histological examination provided the diagnosis of PGCG. After 19-month follow-up, there were no signs of recurrence of peri-implantitis around the implant.Conclusion. The correct diagnosis and appropriate surgical treatment of peri-implant giant cell granuloma are very important for a proper management of the lesion in order to preserve the implant prosthetic rehabilitation and prevent recurrences.

Annular Elastolytic Giant Cell Granuloma Associated with Temporal Arteritis Leading to Blindness

2011 ◽  
Vol 15 (5) ◽  
pp. 293-297 ◽  
Author(s):  
Ilya Shoimer ◽  
Judy Wismer
Keyword(s):  
Giant Cell ◽  
Temporal Arteritis ◽  
Case Reports ◽  
Giant Cells ◽  
Giant Cell Granuloma ◽  
Treatment Regimens ◽  
Steroid Dose ◽  
Granulomatous Disorder ◽  
The Right ◽  
Erythematous Plaques

Background: Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous disorder characterized by giant cells in the dermis phagocytosing damaged elastin fragments. Objective: We report a case of a 71-year-old man presenting with erythematous plaques in predominantly sun-exposed areas. Method: A diagnosis of AEGCG was made based on the clinical and histologic picture, and treatment with systemic steroids was initiated. However, while tapering the steroid dose, the patient developed a radiating headache that progressed to temporal arteritis and eventual blindness in the right eye. Conclusion: There have been only two previous case reports presenting an association between AEGCG and temporal arteritis. This report explores AEGCG and its possible relationship to temporal arteritis along with possible treatment regimens cited in the current literature.

scholarly journals Aggressive Central Giant Cell Granuloma in the Posterior Region of Mandible – A Case Report

2021 ◽  
Vol 11 (4) ◽  
pp. 118-121
Author(s):  
Ajay Sutare ◽  
Ajay Pratap Singh Parihar ◽  
Varsha A.C.
Keyword(s):  
Case Report ◽  
Key Words ◽  
Giant Cell ◽  
Root Resorption ◽  
Osteolytic Lesion ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Mandibular Molar ◽  
Bony Lesion ◽  
Molar Region

Central giant cell granuloma (CGCG) is an uncommon, benign, intraosseous bony lesion of the mandible and maxilla which is variably aggressive in nature. The incidence of an aggressive and recurrence nature is greatest in a female with a ratio of 2:1. Based on the clinical and radiographic features, Central giant cell granuloma can be classified as aggressive and non-aggressive lesions. Here we report a case of central giant cell granuloma in the posterior mandibular molar region which was aggressive in nature. The clinically and radiographically swelling was evaluated with displaced tooth, pain, cortical expansion, and root resorption. The treatment varies according to the nature of the lesion, this case was treated by conservative excision with continuity of the mandible. Key words: Aggressive, central giant cell granuloma, osteolytic lesion.

scholarly journals “Primary Hyperparathyroidism (PHPT) in Children: Two Case Reports and Review of the Literature”

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Gerdi Tuli ◽  
Jessica Munarin ◽  
Daniele Tessaris ◽  
Raffaele Buganza ◽  
Patrizia Matarazzo ◽  
...  
Keyword(s):  
Primary Hyperparathyroidism ◽  
Standard Treatment ◽  
Case Reports ◽  
Osteolytic Lesion ◽  
Recurrent Abdominal Pain ◽  
Definitive Treatment ◽  
Presenting Symptoms ◽  
First Case ◽  
Serum Pth ◽  
Hungry Bone

Primary hyperparathyroidism (PHPT) is a rare disorder in children and adolescents. Typical biochemical features are hypercalcemia and hypophosphatemia, but the clinical features can be heterogeneous, and in some cases, symptoms are vague and nonspecific, leading to misdiagnosis or late diagnosis. Herein, we report two cases of PHPT in pediatric age with different presenting symptoms, pain in the foot, and progressive alteration of the gait in the first case and recurrent abdominal pain with emotional lability in the second. Biochemical and radiological assessment confirmed PHPT. Both cases were treated surgically as definitive treatment, but in the second case, previous medical treatment with cinacalcet, a calcimimetic agent, was required to reduce serum PTH and calcium levels. After surgery, despite conventional treatment with calcium and calcitriol, case 1 developed a hungry bone syndrome. The analysis of the MEN-1 (Multiple Endocrine Neoplasia) gene was negative in both cases. A diagnosis of PHPT should be considered when children or adolescents present bone pain with radiological imaging of osteolytic lesion and biochemical feature of hypercalcemia associated with hypophosphatemia. In PHPT, the gold standard treatment is represented by surgery followed by strict postoperative endocrine monitoring to maintain adequate homeostasis of calcium and bone metabolism.

scholarly journals Central Odontogenic Fibroma Accompanied by a Central Giant Cell Granuloma-Like Lesion: Report of a Case and Review of Literature

2022 ◽  
Author(s):  
Monir Moradzadeh Khiavi ◽  
Abbas Karimi ◽  
Hassan Mirmohammad Sadeghi ◽  
Samira Derakhshan ◽  
Seyed Mobin Tafreshi ◽  
...  
Keyword(s):  
Giant Cell ◽  
Benign Lesion ◽  
Excisional Biopsy ◽  
Giant Cells ◽  
Histopathological Analysis ◽  
Giant Cell Granuloma ◽  
Multinucleated Giant Cells ◽  
Central Giant Cell Granuloma ◽  
Odontogenic Fibroma ◽  
Central Odontogenic Fibroma

Central giant cell granuloma (CGCG) is a benign non-neoplastic intraosseous lesion mainly found in the anterior mandible. It is characterized by multinucleated giant cells, representing osteoclasts or macrophages. Central odontogenic fibroma (COF) is an uncommon benign lesion of the jaws. It originates from the odontogenic ectomesenchyme. In rare cases, COF may accompany a CGCG. To date, 49 cases of COF accompanied by CGCG-like lesions have been reported in the literature. In this paper, we present another case of COF-CGCG in a 46-year-old female. The lesion was located in the posterior mandible. Excisional biopsy was carried out, and histopathological analysis revealed multinucleated giant cells with numerous strands of odontogenic epithelium. A literature review of previously reported cases was also performed.  

Management of recurrent central giant cell granuloma of mandible using intralesional corticosteroid with long-term follow-up

2020 ◽  
Vol 13 (9) ◽  
pp. e237200
Author(s):  
Kumar Nilesh ◽  
Anuj Dadhich ◽  
Rahul Patil
Keyword(s):  
Giant Cell ◽  
Osteolytic Lesion ◽  
Giant Cell Granuloma ◽  
Central Giant Cell Granuloma ◽  
Intralesional Corticosteroid ◽  
Ablative Surgery ◽  
Long Term Follow Up ◽  
Intralesional Injections

Central giant cell granuloma (CGCG) is an expansile osteolytic lesion of the jawbone. Conventional treatment of CGCG is surgical and vary from simple curettage to more aggressive resection of the jaw. However, surgical management is associated with drawbacks including requirement of hospitalisation and general anaesthesia, damage to vital anatomic structures and continuity defect of the mandible requiring reconstruction surgery. Use of intralesional injections of corticosteroid for the management of CGCG have been inconsistently used as an alternative non-surgical method of management of CGCG with varying success. While the use of such conservative modality over ablative surgery can significantly reduce postoperative morbidity, follow-up of such cases for a long period is important to study the possible recurrence. This paper reports successful treatment of a recurrent CGCG of posterior mandible by intralesional administration of triamcinolone acetonide in a 27-year old female patient, with long-term follow-up of 10 years.

scholarly journals Peripheral giant cell granuloma associated with a dental implant

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Rafaela Carriço Porto Baesso ◽  
Maria Carolina de Lima Jacy Monteiro Barki ◽  
Rebeca de Souza Azevedo ◽  
Karla Bianca Fernandes da Costa Fontes ◽  
Débora Lima Pereira ◽  
...  
Keyword(s):  
Giant Cell ◽  
Histological Examination ◽  
Dental Implant ◽  
Excisional Biopsy ◽  
Giant Cells ◽  
Giant Cell Granuloma ◽  
Case Presentation ◽  
Peripheral Giant Cell Granuloma ◽  
Left Mandible

Abstract Background Peripheral giant cell granuloma (PGCG) is an uncommon pathology that affects gingival or alveolar mucosa. Although PGCG can be associated with dental implants, little is known about this lesion and implant osseointegration as well as its etiopathogenesis and the treatments available. This study sought to report a rare case of PGCG associated with dental implant, emphasizing its clinical and histopathological aspects. Case presentation A 53-year-old man had an exophytic, reddish lesion, around a crown attached to a dental implant located in the left mandible. Radiographically, there was bone loss around the implant. After excisional biopsy, histological examination revealed a submucosal proliferation of multinucleated giant cells rendering the diagnosis of peripheral giant cell granuloma. Patient has been under follow-up for 6 months with no recurrence. Conclusions Peri-implant lesions must be completely removed to prevent recurrence of PGCG and implant failure, even in cases suspected to be reactive. Besides, histological examination must be performed on all peri-implant reactions to achieve the appropriate diagnosis and, consequently, the best treatment and follow up.

scholarly journals Peripheral Giant Cell Granuloma: A Case Report

2013 ◽  
Vol 3 (3) ◽  
pp. 31-32
Author(s):  
N Ghimire ◽  
P Nepal ◽  
N Ghimire
Keyword(s):  
Giant Cell ◽  
Excisional Biopsy ◽  
Pathological Examination ◽  
Giant Cell Granuloma ◽  
Cell Hyperplasia ◽  
Medical College ◽  
Large Size ◽  
Peripheral Giant Cell Granuloma ◽  
History Of ◽  
Molar Region

Peripheral giant cell granuloma is a benign reactive lesion of gingiva. It manifests as a firm, soft, bright nodule, sessile or pedunculate mass. It is an infrequent exophytic lesion of the oral cavity, also known as giant cell epulis, osteoclastoma, giant cell reparative granuloma, or giant-cell hyperplasia. The aim in publishing this report is to present the clinical, histo­pathological features and treatment of a peripheral giant cell granuloma case, which was seen in gingiva of a 10 year old male child, with history of disturbed chewing functions due to its large size. Intraoral examination revealed a raised, round, sessile, smooth-edged mass of size 2x 1 cm2 and was located on the canine, deciduous first molar region. After initial peri­odontal treatment, excisional biopsy was performed under local anesthesia. The lesion was diagnosed as Peripheral Giant Cell Granuloma after clinical and pathological examination. DOI: http://dx.doi.org/10.3126/jcmc.v3i3.8635 Journal of Chitwan Medical College 2013; 3(3): 28-30

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